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| Number | Title | Issue Date |
| 8173635 | Kinase inhibitors The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, o... | 05/08/2012 |
| 8168798 | Caspase inhibitor prodrugs This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors. This invention also relates to ... | 05/01/2012 |
| 8163917 | Azaindoles useful as inhibitors of Janus kinases The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatm... | 04/24/2012 |
| 8163772 | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxypheny1]-1,4-dihydro-4-oxoquinoline-3-carboxamide Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof. ... | 04/24/2012 |
| 8163737 | CGRP receptor antagonists The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions. ... | 04/24/2012 |
| 8163732 | Tricyclic heteroaryl compounds useful as inhibitors of Janus kinase The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatm... | 04/24/2012 |
| 8163720 | Pyrrolidinyl phenyl sulphonamides as modulators of ion channels The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of variou... | 04/24/2012 |
| 8158637 | Quinazolines useful as modulators of voltage gated ion channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of... | 04/17/2012 |
| 8153668 | Polymorphic forms of (S)-1-tetrahydrofuran-3-yl-3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate The present invention relates to polymorphic forms of (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate, processes therein, pharmaceutical compositions thereof, and uses therewith. ... | 04/10/2012 |
| 8153655 | Compositions useful as inhibitors of voltage-gated sodium channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of... | 04/10/2012 |
| 8153642 | Quinazolines useful as modulators of ion channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the composition... | 04/10/2012 |
| 8143297 | Heterocyclic derivatives as modulators of ion channels The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of v... | 03/27/2012 |
| 8129546 | Derivatives for modulation of ion channels Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions. ... | 03/06/2012 |
| 8129399 | Aminopyrimidines useful as kinase inhibitors The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various diseas... | 03/06/2012 |
| 8129387 | Substituted 5,6-dihydroimidazo[1,5-F]pteridines useful as protein kinase inhibitors The present invention relates to substituted 5,6-dihydroimidazo[1,5-f]pteridines of formula I: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprisin... | 03/06/2012 |
| 8129381 | Caspase inhibitors and uses thereof The present invention relates to compounds of formula I: useful as inhibitors of caspases. The present invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for preparing the ... | 03/06/2012 |
| 8124781 | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). ... | 02/28/2012 |
| 8124392 | Crystal structure of Aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto... | 02/28/2012 |
| 8119631 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 02/21/2012 |
| 8101770 | Pyridones useful as inhibitors of kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, ... | 01/24/2012 |
| 8101767 | Modulators of ATP-binding cassette transporters The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to metho... | 01/24/2012 |
| 8101378 | Dual expression vector system and screening methods The present invention features vectors that contain a promoter effective for expression in bacterial cells and a promoter effective for expression in insect cells. The dual promoter system allows use of the same vector in both host cell systems so that construction ... | 01/24/2012 |
| 8097636 | Heterocyclic derivatives as modulators of ion channels The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of v... | 01/17/2012 |
| 8093392 | Caspase inhibitors and uses thereof This invention provides novel compounds, and pharmaceutically acceptable derivatives thereof, that are useful as caspase inhibitors. These compounds have the general formula I: where R1, R2, and R... | 01/10/2012 |
| 8076357 | Compositions of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide Pharmaceutical compositions including N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods of using such compositions are described herein. ... | 12/13/2011 |
| 8076343 | Benzimidazoles useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDK1 protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various... | 12/13/2011 |
| 8071618 | Caspase inhibitors and uses thereof The present invention provides a compound of formula I: wherein: X is —OR1 or —N(R5)2, Y is halo, trifluorophenoxy, or tetrafluorophenoxy; R1 ... | 12/06/2011 |
| 8067606 | Gyrase inhibitors and uses thereof The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods... | 11/29/2011 |
| 8067417 | Imidazo[1,2-F]pteridines useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase, represented by Structural Formula (I): wherein the variables in Structural Formula (I) are as described herein. The invention also provides ... | 11/29/2011 |
| 8058271 | Selective inhibitors of rock protein kinase and uses thereof Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurologica... | 11/15/2011 |
| 8039661 | Thiophene-carboxamides useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseas... | 10/18/2011 |
| 8039623 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As ... | 10/18/2011 |
| 8039491 | Modulators of ATP-binding cassette transporters Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The p... | 10/18/2011 |
| 8039475 | Co-crystals and pharmaceutical compositions comprising the same The invention relates to compositions and co-crystals each comprising (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c... | 10/18/2011 |
| 8034950 | Processes for the facile synthesis of diaryl amines and analogues thereof The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the proce... | 10/11/2011 |
| 8034832 | Gyrase inhibitors and uses thereof The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the pr... | 10/11/2011 |
| 8022202 | Dihydrodiazepines useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, o... | 09/20/2011 |
| 8022041 | Prodrug of an ICE inhibitor This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative... | 09/20/2011 |
| 8017781 | Azaindazoles useful as inhibitors of kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, o... | 09/13/2011 |
| 8017619 | Compositions useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositi... | 09/13/2011 |
