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| Number | Title | Issue Date |
| 7629349 | Pyrazolo [3,4-d] pyrimidine derivatives and their use as purinergic receptor antagonists Pharmaceutical compositions and their uses comprising compounds of formula (I): wherein: R1 is selected from: alkyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, halogen, CN, NR6R7, NR5 | 12/08/2009 |
| 7598256 | Pyrrolo [2,3-d] pyrimidine and their use as purinergic receptor antagonists Use of a compound of the formula (I) wherein R1 is selected from alkyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, halogen, CN, NR7R8, NR6COR7, NR6CO2R9 and NR6SO | 10/06/2009 |
| 7589097 | Triazol[4,5-d] pyramidine derivatives and their use as purinergic receptor antagonists The use of a compound of formula (I): wherein R1 is selected from H, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, halogen, CN, NR5R6, NR4COR5, NR | 09/15/2009 |
| 7452894 | Purine derivatives as purinergic receptor antagonists Use of a compound of formula (I) wherein R1 is selected from alkyl, aryl, alkoxy, aryloxy, 0thioalkyl, thioaryl, CN, halo, NR5R6, NR4COR5, NR4CONR5R6, NR4CO2 | 11/18/2008 |
| 7405219 | Triazolo [4,5-d] pyrimidine derivatives and their use as purinergic receptor antagonists The use of a compound of formula (I): wherein R1 is selected from H, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, halogen, CN, NR5R6, NR4COR5, NR | 07/29/2008 |
| 7384949 | Thieno(3,2-d)pyrimidines and furano(3,2-d)pyrimidines and their use as purinergic receptor antagonists A compound of formula (I), wherein X is S or O; R1 is selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, COR5, CO2R5, CONR6R7, CONR5NR6R | 06/10/2008 |
| 7323487 | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 01/29/2008 |
| 7323486 | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 01/29/2008 |
| 7323473 | Condensed indoline derivatives and their use as 5-HT, in particular 5-HT, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 01/29/2008 |
| 7323466 | Morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1 | 01/29/2008 |
| 7173056 | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 02/06/2007 |
| 7166613 | Condensed indoline derivatives and their use as 5HT, in particular 5HT, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 01/23/2007 |
| 7145009 | Pirazino(aza)indole derivatives Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous syste... | 12/05/2006 |
| 7141575 | Triazolo[4,5-d]pyrimidine derivatives and their use as purinergic receptor antagonists The use of a compound of formula (I): wherein R1 is selected from H, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, halogen, CN, NR5R6, NR4CONR5, NR4CONR5R6,NR4CO | 11/28/2006 |
| 7098333 | Pyrrolo[2,3-d]pyrimidine and their use as purinergic receptor antagonists Use of a compound of the formula (I) wherein R1 is selected from alkyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, halogen, CN, NR7R8, NR6COR7, NR6CO2R9 and NR6SO | 08/29/2006 |
| 7087754 | Pyrazolo[3,4-d]pyrimidine derivatives and their use as purinergic receptor antagonists Use of a compound of formula (I): wherein R1 is selected from alkyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, halogen, CN, NR6R7, NR5COR6, NR5CONR6R7, NR5CO2 | 08/08/2006 |
| 7022707 | Piperazine derivatives The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R4, A1, A2 m and n are as descri... | 04/04/2006 |
| 6962939 | Condensed indoline derivatives and their use as 5HT, in particular 5HT, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 11/08/2005 |
| 6831078 | Azetidinecarboxamide derivatives for treating CNS disorders A compound of formula (1) wherein R1 is aryl; and R2 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epi... | 12/14/2004 |
| 6800627 | Pirazino indole derivatives Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous system; damag... | 10/05/2004 |
| 6706750 | Indole derivatives process for their preparation, pharmaceutical compositions containing them and their medicinal application A chemical compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4, R6 and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, ... | 03/16/2004 |
| 6608085 | 4-quinolinemethanol derivatives as purine receptor antagonists (II) Use of a compound of formula (I) as defined herein, or a pharmaceutically acceptable salt or prodrug thereof, in the manufacture of a medicament for the treatment or prevention of a disorder in which the blocking of purine receptors, particularly adenosin... | 08/19/2003 |
| 6583156 | 4-Quinolinemethanol derivatives as purine receptor antagonists (1) ##STR1## Use a compound of formula (I) wherein: R1 is hydrogen or alkyl; R2 and R3 are independently selected from hydrogen, alkyl, aryl and heterocyclyle or together may form a ring or R1 and R2 or R... | 06/24/2003 |
| 6552062 | Indazole derivatives with 5-HT2 receptor activity A chemical compound of formula (I) wherein R1 to R3 are independently selected from hydrogen and alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, monoalkylamino, di... | 04/22/2003 |
| 6531511 | 2-adamantanemethanamine compounds for treating abnormalities in glutamatergic transmission The use of a compound of formula (1), as disclosed in the specification, wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl and aryl, or pharmaceutically acce... | 03/11/2003 |
| 6514961 | Azetidinecarboxamide derivatives for the treatment of CNS disorders A compound of formula (1): ##STR1## wherein R1 is aryl; and R2, R3, R4, R5 and R6 which may be the same or different are selected from H, alkyl and aryl; pharmaceutically acceptable additio... | 02/04/2003 |
| 6500866 | 1-(adamantyl)amidines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Compounds of 1-(adamantyl) amidine and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmittion.... | 12/31/2002 |
| 6403574 | Azetidinecarboxamide derivatives for treating CNS disorders ##STR1## A compound of formula (1), wherein: R1 is aryl; R2 is H, alkyl or aryl; and R3 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and the use of the compounds in therapy, particularly fo... | 06/11/2002 |
| 6380238 | Indoline derivatives as 5-HT2B and or 5-HTC receptor ligands For use in therapy a chemical compound of formula (I), ##STR1## wherein R1 to R3 are independently selected from hydrogen and alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, ar... | 04/30/2002 |
| 6365598 | Pyrroloquinolines for treatment of obesity ##STR1## A chemical compound of formula (I), wherein R1 to R3 are independently selected from hydrogen and alkyl; R4 is selected from hydrogen, alkyl, alkoxy, formyl and cyano; X1 is selected from N and C--R... | 04/02/2002 |
| 6262106 | Adamantanecarboximidamide derivatives and their use as NMDA antagonists ##STR1## The compound of the above formula wherein R1-R5 are independently selected from hydrogen, alkyl and aryl and prodrugs thereof; and pharmaceutically acceptable salts thereof; and use of the compounds in therapy, particularly for treatment of a con... | 07/17/2001 |
| 6197788 | (-)-mefloquine to block puringergic receptors and to treat movement or neurodegenerative disorders The present invention relates to the use of (&#b1;)-R*,S*)-alpha-2-piperidnyl-2,8-bis(trifluoromethyl)-4-quinolinemthan ol and in particular (-)-(11S,2'R)-alpha-2-piperidnyl-2,8-bis(trifluoromethyl)-4-quinolinemthan ol in the treatment of disorders in ... | 03/06/2001 |
