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| Number | Title | Issue Date |
| 8147773 | Method and apparatus for modifying pressure within a fluid dispenser A fluid dispenser useful in automated biological reaction systems comprising a barrel having a reservoir chamber, the barrel having an upper portion and a lower portion, a cap located on top of the upper portion of the barrel and connected to the reservoir chamber, ... | 04/03/2012 |
| 8068988 | Method for automated processing of digital images of tissue micro-arrays (TMA) A method and system for automated quantitation of tissue micro-array image (TMA) digital analysis. The method and system automatically analyze a digital image of a TMA with plural TMA cores created using a needle to biopsy or other techniques to create standard hist... | 11/29/2011 |
| 8048373 | Automated high volume slide staining system An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations. ... | 11/01/2011 |
| 8026106 | Removal of mercuric chloride crystals from fixed tissues Mercuric chloride precipitates are removed from biological cell samples fixed with mercuric chloride and held in an embedding media, by contacting the biological cell samples with an aqueous solution containing a surfactant, and incubating at a temperature in excess... | 09/27/2011 |
| 7985557 | Polymeric carriers for immunohistochemistry and in situ hybridization Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecul... | 07/26/2011 |
| 7979212 | Method and system for morphology based mitosis identification and classification of digital images A method and system for morphology based mitosis identification and classification of digital images. Luminance parameters such as intensity, etc. from a digital image of a biological sample (e.g., tissue cells) to which a chemical compound (e.g., a marker dye) has ... | 07/12/2011 |
| 7941275 | Method and system for automated detection of immunohistochemical (IHC) patterns A method and system for automated detection of immunohistochemical (IHC) patterns. The method and system is able to automatically differentiate an epithelial cell part from a non-epithelial cell part of a digital image of a tissue sample to which an IHC compound has... | 05/10/2011 |
| 7935534 | Automated molecular pathology apparatus having fixed slide platforms Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternat... | 05/03/2011 |
| 7860727 | Laboratory instrumentation information management and control network An interface point network (IPN) and a method for communication with a laboratory information system using an IPN, wherein the IPN includes at least one host computer in communication with at least one laboratory instrument, the laboratory information system and an ... | 12/28/2010 |
| 7851145 | Na, K-ATPase expression in cervical dysplasia and cancer The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na+, K+-ATPase expression. For example, it is demonstrated herein that expression of the Na+, K+-ATPase β1-subunit ... | 12/14/2010 |
| 7838655 | Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in-situ analysis The present invention provides oligonucleotide probes and oligonucleotide probe collections and protein labeling for detecting or localizing a plurality nucleic acid target genes or antigens within a cell or tissue sample. Specifically, the invention provides collec... | 11/23/2010 |
| 7833698 | Method for determining the response to cancer therapy The invention relates to a method for determining the response to cancer therapy in an individual using image analysis. ... | 11/16/2010 |
| 7820381 | Method and apparatus for applying fluids to a biological sample The invention is directed to a method of contacting a biological sample with a solution, comprising the steps of moving a curved surface wetted with the solution in proximity to the biological sample whereby the distance separating the wetted curved surface and the ... | 10/26/2010 |
| 7763421 | Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation This invention describes methods for generating nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of nucleic acids that promote network formation during hybridization with the res... | 07/27/2010 |
| 7727774 | Method and apparatus for automated coverslipping An apparatus and method for selecting and dispensing coverglasses over specimens on slides for the purpose of viewing specimens through a microscope. The selecting device contains a suctioning mechanism for picking up a coverglass from a stack of coverglasses. It al... | 06/01/2010 |
| 7695929 | Haptens, hapten conjugates, compositions thereof and method for their preparation and use A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different tar... | 04/13/2010 |
| 7682789 | Method for quantifying biomolecules conjugated to a nanoparticle Disclosed embodiments concern quantifying a biomolecule conjugated to a nanoparticle. Quantifying typically comprises determining the number of biomolecules per nanoparticle. Any suitable biomolecule can be used, including but not limited to, amino acids, peptides, ... | 03/23/2010 |
| 7642064 | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an analyte of interest in the presence of a redox-inactive reductive species an... | 01/05/2010 |
| 7632652 | Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences The invention is directed to novel compositions of matter and methods of detecting in situ an immunohistochemical epitope or nucleic acid sequence of interest in a biological sample comprising binding an enzyme-labeled conjugate molecule to the epitope or sequence o... | 12/15/2009 |
| 7618807 | Apparatus for electrophoretic in situ tissue staining The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion ... | 11/17/2009 |
| 7615371 | Method and apparatus for treating a biological sample with a liquid reagent A method and apparatus for treating a biological sample with a liquid reagent, comprising first and second substrates having facing surfaces defining a space therebetween in which the biological sample may be treated with the liquid reagent, wherein the first substr... | 11/10/2009 |
| 7550298 | Automated immunohistochemical and in situ hybridization assay formulations Provided herein are reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The reagents include, bu... | 06/23/2009 |
| 7541455 | Microwave mediated synthesis of nucleic acid probes A method for preparing a nucleic acid probe is provided. The method comprises forming an activated cytosine or cytidine by a bisulfite catalyzed reaction; and covalently linking a reporter molecule to the activated cytosine or cytidine, wherein said activating step,... | 06/02/2009 |
| 7468161 | Automated high volume slide processing system An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that... | 12/23/2008 |
| 7425306 | Slide heater A slide heater for use in a slide processing apparatus in which an interface surface between the slide heater and the slide has a plurality of slots or channels terminating in an edge thereof, for gathering and venting gas bubbles. ... | 09/16/2008 |
| 7419777 | Method and quantification assay for determining c-kit/SCF/pAKT status This invention provides methods for determining or predicting response to cancer therapy in an individual using differential image analysis of immunohistochemically stained tumor samples. ... | 09/02/2008 |
| 7410753 | Removal of embedding media from biological samples and cell conditioning on automated staining instruments The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The reagents com... | 08/12/2008 |
| 7404927 | Automated molecular pathology apparatus having fixed slide platforms Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides. ... | 07/29/2008 |
| 7396508 | Automated molecular pathology apparatus having independent slide heaters Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platfor... | 07/08/2008 |
| 7378058 | Method and apparatus for modifying pressure within a fluid dispenser A fluid dispenser useful in methods and apparatuses for automated biological reaction systems including a barrel, a coupler, a piston associated with the barrel, and a sealing surface that seals the inner diameter against fluid flow at the lower extent of the piston... | 05/27/2008 |
| 7378055 | Automated molecular pathology apparatus having fixed slide platforms Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternat... | 05/27/2008 |
| 7303725 | Automated high volume slide staining system An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations. ... | 12/04/2007 |
| 7300748 | Method for enhancing staining of microorganisms The invention is directed to a method and composition of matter for enhancing the staining of tissue or features of interest therein by applying an effective amount of a bile salt in combination with a special stain to a tissue suspected of harboring a microorganism... | 11/27/2007 |
| 7292718 | Color space transformations for use in identifying objects of interest in biological specimens Two color transformations, as described herein, facilitate identification of the objects of interest in the biological specimen. One of the color transformations, a Minus Clear Plus One (MC+1) transformation, can be conceptualized as either translating and rotating ... | 11/06/2007 |
| 7270785 | Automated molecular pathology apparatus having fixed slide platforms Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides. ... | 09/18/2007 |
| 7271006 | Method and apparatus for automated coverslipping An apparatus and method for selecting and dispensing coverglasses over specimens on slides for the purpose of viewing specimens through a microscope. The selecting device contains a suctioning mechanism for picking up a coverglass from a stack of coverglasses. It al... | 09/18/2007 |
| 7251363 | Method and system for creating an image mask A method and system is described for creating a mask that isolates a region of interest in a digital image. The mask is created using a second underlay image that is initialized to 255 pixel values (white). A user identifies a region of interest in the digital image... | 07/31/2007 |
| 7250254 | Multiple fusion probes A method of detecting reciprocal gene translocations by employing multiple probe sets which span the breakpoint regions and encompass regions on both sides of each breakpoint of the translocation on each chromosome involved in the translocation. Probe sets and diagn... | 07/31/2007 |
| 7220589 | Slide acqueous volume controlling apparatus Apparatus and methods for controlling the fluid on a slide are provided. Fluid reduction is accomplished by directing stream(s) of fluid at an edge of the slide, the streams of fluid being at an angle with the slide of less than 90°. The surface tension at the edge... | 05/22/2007 |
| 7200252 | Color space transformations for use in identifying objects of interest in biological specimens Two color transformations, as described herein, facilitate identification of the objects of interest in the biological specimen. One of the color transformations, a Minus Clear Plus One (MC+1) transformation, can be conceptualized as either translating and rotating ... | 04/03/2007 |
