Assignee: Vanderbilt University

Location: Nashville, TN
No. of patents: 389

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Number	Title	Issue Date
8168804	Large stoke shift NIR dyes A compound of the following formula: wherein R1 is SO3H; R2 is chosen from carboxylic acid group and SO3H; and R3 is chosen from Cl, carboxylic acid group, amino, amino...	05/01/2012
8168656	Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with and modulate the activities of o...	05/01/2012
8168084	Polar nematic compounds Polar nematic compounds, one example of which has the following structure: is a caged boron structure, where the sphere of the caged boron structure is C and each non-sphere vertex of the c...	05/01/2012
8158344	Methods and compositions for correlating genetic markers with multiple sclerosis The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence of a nucleotide variant in the interleukin 7 receptor alpha chain gen...	04/17/2012
8153368	Four-jointed box (FJX1) in cancer diagnosis and treatment The present invention relates to a new tumor suppressor, designated FJX1. Also described are diagnostic, prognostic and therapeutic uses of the FJX1 protein and the FJX1 gene, alone or in combination with traditional cancer therapies. ...	04/10/2012
8152809	Flat cut bit for cranial perforator Described herein is a cranial surgery drill bit having a safety self stopping mechanism for use on bone material to prevent or repair skin erosion and infection which may result from the placement of a cap for holding the lead from Deep Brain Stimulation surgery. Th...	04/10/2012
8148170	Immunosensors: scFv-linker design for surface immobilization An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid su...	04/03/2012
8143302	Methods and compositions for diagnostic and therapeutic targeting of COX-2 The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell an...	03/27/2012
8134707	On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26) formed therein. A polarized laser beam (14) is direct...	03/13/2012
8129356	Bmx mediated signal transduction in irradiated vascular endothelium Provided are methods for modulating the proliferation of cells and tissues. In some embodiments, the methods include administering to a subject an effective amount of a modulator of a biological activity of a bone marrow X kinase (Bmx) gene product. Also provided ar...	03/06/2012
8129179	Bioreactors with an array of chambers and a common feed line A bioreactor (200) for cultivating living cells in a liquid medium. In one embodiment, the bioreactor (200) has a substrate (230) having a first surface and an opposite second surface, defining a channel (202) therein, and a plurality of ...	03/06/2012
8120777	Temperature-stable interferometer This invention provides an interferometric detection device configured to maintain a temperature of a sensing area to within 20 m° C. of a first target temperature and to maintain a temperature of the medium within 500 m° C. of a second target temperature The devi...	02/21/2012
8116549	Method and apparatus for standardizing ultrasonography training using image to physical space registration of tomographic volumes from tracked ultrasound A clinical and training apparatus that collects and processes physical space data while performing an image-guided procedure on an anatomical area of interest includes a calibration probe, a tracked ultrasonic probe, a wireless tracking device that tracks the ultras...	02/14/2012
8109630	Illuminated low-vision spectacles Lighted reading glasses for individuals with low vision. In one embodiment, the reading glasses include a frame for supporting lenses having an oculus dexter side and an oculus sinister side, at least one oculus dexter lens supported by the frame on the oculus dexte...	02/07/2012
8101157	Ligands to radiation-induced molecules A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse mo...	01/24/2012
8088587	Genetic variants increase the risk of age-related macular degeneration Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD, but it was not identified. We...	01/03/2012
8088352	Graphitic-carbon-nanofiber/polymer brushes as gas sensors A composition of matter including at least one graphitic-carbon-nanofiber/polymer brush. A method of making the graphitic-carbon-nanofiber/polymer brush includes covalently bonding a polymer to a surface of a graphitic-carbon-nanofiber by atom-transfer-radical-polym...	01/03/2012
8073216	System and methods for automatic segmentation of one or more critical structures of the ear A system and method for automatic segmentation of a structure of interest of an ear are disclosed, where the structure of interest includes the facial nerve and chorda tympani. In one embodiment, the method combines an atlas-based approach with a minimum cost path f...	12/06/2011
8066644	System, method and device for positioning a target located within soft tissue in a path of an instrument A system, method and device for positioning a target located within soft tissue in a path of an instrument inserted into the soft tissue includes: a manipulation system including a plurality of force applicators positioned around the soft tissue containing the targe...	11/29/2011
8065014	Method for promoting selective reinnervation of denervated tissue A method for promoting reinnervation via stimulation of a denervated target tissue, whereby reinnervation of the target tissue by native neurons is enhanced, and whereby reinnervation of the target tissue by foreign neurons is inhibited. ...	11/22/2011
8060272	System and method for image mapping and visual attention A method is described for mapping dense sensory data to a Sensory Ego Sphere (SES). Methods are also described for finding and ranking areas of interest in the images that form a complete visual scene on an SES. Further, attentional processing of image data is best ...	11/15/2011
8052034	Lateral position detection and control for friction stir systems Friction stir methods are disclosed for processing at least one workpiece using a rotary tool with rotating member for contacting and processing the workpiece. The methods include oscillating the rotary tool laterally with respect to a selected propagation path for ...	11/08/2011
8050766	Respiratory triggered, bilateral laryngeal stimulator to restore normal ventilation in vocal fold paralysis A laryngeal stimulation system including a sensor for detecting an occurrence of a respiratory signal in a subject and a laryngeal stimulator adapted for coupling to a laryngeal muscle and operable to stimulate the laryngeal muscle in response to the sensor detectin...	11/01/2011
8048940	Reactive graphitic carbon nanofiber reinforced polymeric composites showing enhanced flexural strength Composites comprising at least one graphite-carbon nanofiber (GCNF) and a polymer phase covalently linked to a surface thereof. ...	11/01/2011
8034806	Bicyclic mGluR5 positive allosteric modulators and methods of making and using same In one aspect, the invention relates to bicyclic MGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic...	10/11/2011
8031338	Measuring Forster resonance energy transfer with polarized and depolarized light The present invention provides improved methods for assessing Förster resonance energy transfer using polarized light. Specifically, the methods rely on measuring depolarized light emitted by fluorescent acceptor molecules. ...	10/04/2011
8021671	Pro-apoptotic bacterial vaccines to enhance cellular immune responses Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of enhancing antigen presentation by intracellular bacteria in a manner th...	09/20/2011
8012945	Phage antibodies to radiation-inducible neoantigens A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) iso...	09/06/2011
8003378	Capillary perfused bioreactors with multiple chambers A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate havin...	08/23/2011
7994234	Diamond polymer brushes A composite comprising at least one diamond/polymer brush and a method of making the composite comprising covalently bonding at least one polymer to said diamond surface. ...	08/09/2011
7981649	Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate...	07/19/2011
7981122	Adjustable surgical platform and surgical instrument using same In one aspect, the present invention relates to a surgical instrument for providing an access to a target of interest of a living subject. In one embodiment, the surgical instrument has a bearing member, a shaft member and a probe. The bearing member has a first end...	07/19/2011
7979107	System and method for differentiation of normal and malignant in vivo liver tissues A method for differentiating malignant in vivo liver tissues from normal in vivo liver tissues of a living subject includes the steps of: (a) illuminating a first area and a second area of in vivo liver tissues of the living subject with a first excitation light, (b...	07/12/2011
7977089	Bioreactors with multiple chambers A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liqu...	07/12/2011
7974003	Photolithographed micro-mirror well for 3D tomogram imaging of individual cells A micro-mirror well. In one embodiment the micro-mirror well includes a plurality of planar mirrors arranged around an axis of symmetry and inclined to form a pyramid well, where each of the plurality of planar mirrors is capable of reflecting light emitting from an...	07/05/2011
7968675	In vivo panning for ligands to radiation-induced molecules A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) iso...	06/28/2011
7957808	System and methods of deep brain stimulation for post-operation patients A method for programming a deep brain stimulator implanted in a target region of a brain of a living subject. In one embodiment, the method comprises the steps of creating an efficacy atlas; acquiring a position of each electrode contact of the at least one electrod...	06/07/2011
7951181	System and methods for optical stimulation of neural tissues The present invention, in one aspect, relates to a system for stimulating neural tissue of a living subject. The system comprises an energy source capable of generating optical energy, a connector having a first end and a second end capable of transmitting optical e...	05/31/2011
7947255	Fluorescent substrates for neurotransmitter transporters The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The i...	05/24/2011
7942522	Illuminated low-vision spectacles Lighted reading glasses for individuals with low vision. In one embodiment, the reading glasses include a frame for supporting lenses having an oculus dexter side and an oculus sinister side, at least one oculus dexter lens supported by the frame on the oculus dexte...	05/17/2011

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Assignee: Vanderbilt University