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| Number | Title | Issue Date |
| 8182809 | Methods for treating cancer by inhibiting MIC shedding Described herein are compositions and methods for treating cancer, comprising administering to an individual having cancer an agent to prevent MIC shedding (initiated at the alpha-3 ectodomain of MIC) by a tumor cell. Also provided herein are screening assays for id... | 05/22/2012 |
| 8178091 | Compositions and methods for the treatment of respiratory disorders Methods and compositions are provided for the treatment of acute lung injury and pulmonary fibrosis by administering inhibitors of IGF-1R signaling activity. ... | 05/15/2012 |
| 8174700 | Portable and cartridge-based surface plasmon resonance sensing systems This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to ... | 05/08/2012 |
| 8173413 | Separation and concentration of biological cells and biological particles using a one-dimensional channel This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel configured to concurrently allow fluid flow while precluding passage o... | 05/08/2012 |
| 8173045 | Diels-Alder crosslinkable dendritic nonlinear optic chromophores and polymer composites Diels-Alder crosslinkable dendritic nonlinear optical chromophore compounds, films and crosslinked polymer composites formed from the chromophore compounds, methods for making and using the chromophore compounds, films, and crosslinked polymer composites, and electr... | 05/08/2012 |
| 8163865 | Biocompatible amino acid anhydride polymers Biocompatible amino acid anhydride polymers for use in tissue engineering, and methods for their preparation and use. ... | 04/24/2012 |
| 8158556 | Activated carbon cryogels and related methods Carbon cryogels, methods for making the carbon cryogels, methods for storing a gas using the carbon cryogels, and devices for storing and delivering a gas using the carbon cryogels. ... | 04/17/2012 |
| 8154787 | Electrochromic materials Green electrochromic (EC) materials based on thiophene, and a green EC material based on pyrazine are disclosed. A first thiophene derivative (2,3-Di-thiophen-2-yl-thieno[3,4-b]pyrazine), which was previously investigated as a nonlinear optical material, is here dis... | 04/10/2012 |
| 8153843 | Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria... | 04/10/2012 |
| 8153366 | Methods and compositions for predicting drug responses The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes deri... | 04/10/2012 |
| 8147858 | Alginate-based nanofibers and related scaffolds Alginate nanofibers, scaffolds that include alginate nanofibers, implantable devices that include alginate nanofibers, and methods for making the alginate nanofibers by electrospinning. ... | 04/03/2012 |
| 8142369 | Measurement and use of in-socket residual limb volume change data for prosthetic fitting Changes in the volume of residual limbs on which prosthetic sockets are worn can be measured based on bioimpedance measurements along one or more segments of the limb. A current at an appropriate frequency (e.g., in the range from 1 kHz to 1 MHz) is injected at two ... | 03/27/2012 |
| 8142168 | Vibration-driven droplet transport devices having textured surfaces Methods and devices for moving a droplet on an elongated track on a textured surface using vibration. The elongated track on the textured surface includes a plurality of transverse arcuate projections such that a droplet on the surface is in the Fakir state and when... | 03/27/2012 |
| 8140043 | Simplified high frequency tuner and tuning method A disdosed method tunes a signal from a channelized spectrum having a predetermined channel spacing. A signal of interest having a predetermined maximum bandwidth is mixed with a local oscillator signal, which has a frequency that is an integer multiple of the chann... | 03/20/2012 |
| 8137615 | Automated workstation for disinfecting objects and methods of use thereof An automated workstation or apparatus for disinfecting an object in a controlled environment is provided. A method for disinfecting an object in a controlled environment is provided. ... | 03/20/2012 |
| 8133679 | Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in... | 03/13/2012 |
| 8131336 | Automated in vivo plaque composition evaluation A method for the automated segmentation of in vivo image data is disclosed. A region of carotid artery in a number of patients was imaged using MRI. Histological data for each imaged region was then obtained, identifying various atherosclerotic plaque components in ... | 03/06/2012 |
| 8126578 | Clipped-waveform repair in acoustic signals using generalized linear prediction A method and system for optimally repairing a clipped audio signal. Clipping occurs when a waveform exceeds a dynamic range of a recording device. Portions of an audio signal exceeding the dynamic range or saturation level of the recording device are clipped, causin... | 02/28/2012 |
| 8119773 | Compositions and methods for facilitating heme-iron export from cells The invention provides a high affinity heme-binding agent, which can be provided in the form of a pharmaceutical composition that includes, optionally, a pharmaceutically acceptable carrier. The heme-binding agent can be used in a method of facilitating heme-iron ex... | 02/21/2012 |
| 8116705 | Simplified high frequency tuner and tuning method A disclosed method tunes a signal from a channelized spectrum having a predetermined channel spacing. A signal of interest having a predetermined maximum bandwidth is mixed with a local oscillator signal, which has a frequency that is an integer multiple of the chan... | 02/14/2012 |
| 8105831 | Parvoviral production of HLA homozygous cells The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells. ... | 01/31/2012 |
| 8101640 | Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria... | 01/24/2012 |
| 8101403 | Method and device for rapid parallel microfluidic molecular affinity assays Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume fl... | 01/24/2012 |
| 8098965 | Electroabsorption modulator based on fermi level tuning A novel electroabsorption modulator based on tuning the Fermi level relative to mid-gap states in a semiconductor. The modulator includes a semiconductor waveguide that has an input port and an output port. Between the input port and the output port is a section of ... | 01/17/2012 |
| 8092626 | Foaming methods for making cellular thermoplastic materials Methods for reducing the density of thermoplastic materials and the articles made therefrom having similar or improved mechanical properties to the solid or noncellular material. Also disclosed are improvements to foaming methods and the cellular structures of the f... | 01/10/2012 |
| 8088745 | Methods for assaying alpha-L-iduronidase enzymatic activity Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I. ... | 01/03/2012 |
| 8084615 | Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria... | 12/27/2011 |
| 8081180 | Function-based representation of N-dimensional structures A method is disclosed for the solid modeling of objects that is particularly suitable to modeling objects obtained from scan data, typically voxel-based data, for example medical imaging data. The method provides a more direct approach to providing solid modeling ca... | 12/20/2011 |
| 8071733 | Antibodies that specifically bind hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic do... | 12/06/2011 |
| 8067724 | All-optical integrated photonic clock having a delay line for providing gate signal to a gate waveguide An all-optical integrated photonic clock, systems employing the same, and methods of making and using the same. Illustrative examples are provided based on silicon semiconductor technology that employs rectangular waveguides fabricated on SOI wafers. In some embodim... | 11/29/2011 |
| 8067010 | Immunological herpes simplex virus antigens and methods for use thereof The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells... | 11/29/2011 |
| 8063131 | Nanoparticle-amphipol complexes for nucleic acid intracellular delivery and imaging Nanoparticle-amphiphilic polymer complexes for nucleic acid delivery and real-time imaging. ... | 11/22/2011 |
| 8062903 | Droplet compartmentalization for chemical separation and on-line sampling Methods and devices are provided for overcoming detrimental diffusive effects in a sample liquid stream by forming segmented liquid bodies (e.g., droplets) from a sample liquid stream in an immiscible liquid stream. The liquid bodies are formed at the intersection o... | 11/22/2011 |
| 8048850 | Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods fo... | 11/01/2011 |
| 8031985 | Optical XOR logic gate An all-optical XOR logic gate. In one embodiment, a single photon absorption medium is used to provide enhanced optical response of a gate to an applied optical signal. The apparatus described uses at least two gate inputs and an optical modulation structure such as... | 10/04/2011 |
| 8019431 | Enhanced signal processing for cochlear implants The restoration of melody perception is a key remaining challenge in cochlear implants. A novel sound coding strategy is proposed that converts an input audio signal into time-varying electrically stimulating pulse trains. A sound is first split into several frequen... | 09/13/2011 |
| 8016757 | Non-invasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound Ultrasound data are collected from a thermal source and a mass of tissue before initiating therapy to measure two parameters of the bio-heat transfer equation (BHTE). The parameters are the thermal diffusivity (K) of the tissue and the magnitude of the thermal sourc... | 09/13/2011 |
| 8008025 | Biomarkers for neurodegenerative disorders The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene product expression in a cerebrospinal fluid sample and comparing the... | 08/30/2011 |
| 8005450 | Simplified high frequency tuner and tuning method A disclosed method tunes a signal from a channelized spectrum having a predetermined channel spacing. A signal of interest having a predetermined maximum bandwidth is mixed with a local oscillator signal, which has a frequency that is an integer multiple of the chan... | 08/23/2011 |
| 8003948 | Data acquisition for positron emission tomography A method for estimating the start time of an electronic pulse generated in response to a detected event, for example the start time for pulses received in response to photon detection in positron emission tomography, includes providing a detector that detects an ext... | 08/23/2011 |
