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| Number | Title | Issue Date |
| 7052720 | Spheroid preparation A mixture or substance having a spheroid-forming activity is obtained by heat treating fetal calf serum at a temperature and for a period sufficient to impart spheroid-forming activity. Introduced into cell culture, the substance or mixture so obtained causes cells ... | 05/30/2006 |
| 6984520 | Bioassay for thyroid stimulating antibodies An assay method for TSH-R autoantibodies or TSH comprises contacting a test sample, in the presence or absence of TSH, with cells from a clone expressing human TSH-R transfected with a reporter construct comprising cDNA of both (i) a reactant, such as an enzyme, cap... | 01/10/2006 |
| 6945779 | Tooth inclination assessment A tooth inclination apparatus for allowing assessment of the angle of inclination of an incisor tooth or cast thereof includes a plane element providing a flat datum surface for resting against e.g. the upper molars in the maxillary plane. From the underside of the ... | 09/20/2005 |
| 6936618 | Cystic fibrosis medicaments The use of a type V cyclic nucleotide phosphodiesterase inhibitor for the preparation of a medicament for the treatment of cystic fibrosis. ... | 08/30/2005 |
| 6599907 | Cystic fibrosis medicaments A method of treating cystic fibrosis in a patient comprising: administering to said patient an effective amount of a type V cyclic nucleotide phosphodisterase inhibitor, wherein said inhibitor is a compound of formula (I): ##STR1## wherein A is a five- or six... | 07/29/2003 |
| 6492500 | Modified bioluminescent proteins and their use A modified bioluminescent protein responds to different physical, chemical, biochemical or biological conditions to product light or radiation of altered characteristics when the bioluminescent reaction is initiated. The modified bioluminescent protein ma... | 12/10/2002 |
| 6479288 | Method and apparatus for introducing substances into the cell plasma membrane and/or cytosol There is disclosed a method for introducing agents into the cytosol and/or plasma membrane of a cell. The method comprises the steps of: (a) coating at least a portion of a tip of a transferring means with a lipid; (b) bringing the lipid-coated tip of the... | 11/12/2002 |
| 6440665 | Modified bioluminescent proteins and their use A modified bioluminescent protein responds to different physical, chemical, biochemical or biological conditions to product light or radiation of altered characteristics when the bioluminescent reaction is initiated. The modified bioluminescent protein ma... | 08/27/2002 |
| 6355624 | Measurement of plasma volume A method of determining the presence or onset of capillary leakage includes introducing into the blood stream of the subject a first low dosage of a low molecular weight macromolecular material and determining the volume of distribution thereof (an appare... | 03/12/2002 |
| 6117091 | Anorectal angle measurement Apparatus (10) for measuring the anorectal angle comprises an outer rubber-like sheath (12), which may be a suitably modified catheter, within which is disposed an elongate angular deflection detector (14) which provides on display (16) a read-out of the ... | 09/12/2000 |
| 5979443 | Closed ventilation/anesthesia apparatus An inhalation apparatus, which supplies appropriate volumes of oxygen to a closed breathing system, to replace the oxygen used by a patient. A variable volume enclosure is situated within a container, which has an inlet connected to a ventilator for the s... | 11/09/1999 |
| 5977333 | DNA sequence encoding the myotonic dystrophy gene and uses thereof A nucleotide sequence, specifically a CTG triplet repeat, is shown to be expanded in individuals affected with myotonic dystrophy and can be identified in a sample obtained from an individual. Individuals in whom the CTG triplet repeat is present in norma... | 11/02/1999 |
| 5955265 | DNA sequence encoding the myotonic dystrophy gene and uses thereof A method by which a nucleotide sequence, specifically a CTG triplet repeat, shown to be expanded in individuals affected with myotonic dystrophy can be identified in a sample obtained from an individual. The present method can be used to identify individu... | 09/21/1999 |
| 5693465 | Methods for predicting the behaviour of breast tumours The estrogen-regulated gene sequence pLIV1 has been discovered and isolated, and found to be significantly associated with the metastatic spread of breast cancer cells to the regional lymph nodes. Methods are therefore provided for determining the risk of... | 12/02/1997 |
| 5683888 | Modified bioluminescent proteins and their use A modified bioluminescent protein responds to different physical, chemical, biochemical or biological conditions to produce light or radiation of altered characteristics when the bioluminescent reaction is initiated. The modified bioluminescent protein ma... | 11/04/1997 |
| 5292499 | Method of preparing medical aerosol formulations including drug dissolved in reverse micelles The present invention provides a method for the production of medicinal aerosol compositions which are made up of a homogenous solution of aerosol propellants, a surfactant and a pharmaceutically active compound, where the process comprises purifying the ... | 03/08/1994 |
| 5080104 | Proximity detector with a medical instrument A surgical or medical implement including a proximity detector to indicate the distance from an internal organ or member such as an artery. In one form the invention is applied to a surgical scalpel (12) with an audio transducer in contact with the blade ... | 01/14/1992 |
