Assignee: University of Virginia Patent Foundation

Location: Charlottesville, VA
No. of patents: 212

Number	Title	Issue Date
8179216	Capillary force actuator device and related method of applications An actuator capable of generates force by leveraging the changes in capillary pressure and surface tension that result from the application of an electrical potential. The device, which will be referred to as a Capillary Force Actuator (CFA), and related methods, em...	05/15/2012
8178545	Dual small molecule inhibitors of cancer and angiogenesis The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule polymerization. The present further provides methods of treating cancers comprisin...	05/15/2012
8178509	Method to treat sickle cell disease The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount of an A2A adenosine receptor agonist. Optionally, the method includes administration...	05/15/2012
8176635	Manufacture of lattice truss structures from monolithic materials Methods and systems to manufacture lattice-based sandwich structures from monolithic material. Such methods and systems eliminate the bonding process which is conventionally used to join lattice based truss cores to facesheets to form sandwich structures. This bonde...	05/15/2012
8173710	Bicyclic sphingosine 1-phosphate analogs Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. ...	05/08/2012
8158604	2-propynyl adenosine analogs having A2A agonist activity and compositions thereof The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here. ...	04/17/2012
8135548	Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor related signals, verifying the presence of signal attenuation when the...	03/13/2012
8124178	Method and apparatus application of metallic alloy coatings A directed vapor deposition (DVD) method and system for applying at least one bond coating on at least one substrate for thermal barrier coating systems. To overcome the limitations incurred by conventional methods, the DVD system uses an electron beam directed vapo...	02/28/2012
8119984	Method and apparatus for generation of reagent ions in a mass spectrometer A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the rea...	02/21/2012
8114608	Methods for treating and diagnosing fibrotic and fibroproliferative diseases The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease. ...	02/14/2012
8110043	Apparatus and method for applying coatings onto the interior surfaces of components and related structures produced therefrom A methodology and system for applying coatings onto the interior surfaces of components, includes a vapor creation device, a vacuum chamber having a moderate gas pressure and an inert gas jet having controlled velocity and flow fields. The gas jet is created by a ra...	02/07/2012
8093782	Specialized, high performance, ultrasound transducer substrates and related method thereof Backing substrates for reducing parasitic echoes produced within a ultrasonic transducer are provided comprising a polymeric material, for example, an epoxy having a glass transition temperature (Tg) ranging from about 10 to 50° C.; or an epoxy having an...	01/10/2012
8084086	Reliant thermal barrier coating system and related methods and apparatus of making the same A method and apparatus for forming a thermal barrier coating system (90) in communication with at least a portion of at least one substrate (92). The method includes: depositing a first bond coat (94) on at least a portion of at least one substr...	12/27/2011
8058259	Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as AR agonists The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosi...	11/15/2011
8056881	Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof The present invention relates to microfluidic devices, and in particular, flow management in such devices. In particular, the present invention provides an electrostatic valve for flow manipulation in a microfluidic device. The valve of the present invention sits on...	11/15/2011
8012484	Method of treating ischemia reperfusion injury by inhibiting NKT cell activity The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A2A adenosine receptors (ARs). ...	09/06/2011
8008286	Method for treatment of neuropathic pain Compounds and methods useful for preventing and treating pain, e.g., neuropathic pain, in a subject in need thereof are provided. The compounds can be “S1P modulating” agents that are capable of inducing a detectable change in S1P receptor activity. ...	08/30/2011
8007450	Systems, devices, and methods for interpreting movement According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained f...	08/30/2011
8000161	Method and system for encoding to eliminate parasitics in crossbar array memories A method of encoding data stored in a crossbar memory array, such as a nanowire crossbar memory array, to enable significant increases in memory size, modifies data words to have equal numbers of ‘1’ bits and ‘0’ bits, and stores the modified words together ...	08/16/2011
7989431	2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein. ...	08/02/2011
7964649	Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity Hydrindane analogs that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at S1P receptors. ...	06/21/2011
7963085	Multifunctional periodic cellular solids and the method of making same Methods of making truss-based periodic cellular solids that have improved structural properties and multifunctional design. Many materials (metals, ceramics, glasses, polymers, composites and even semiconductors) can be shaped into cellular, truss-like architectures...	06/21/2011
7960588	Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resis...	06/14/2011
7955861	Luminescent diketonate polymers The present invention provides in one aspect polymeric luminescent dye compounds having fluorescent properties, phosphorescent properties, or both fluorescent and phosphorescent properties. ...	06/07/2011
7949498	Method, system and computer program product for registration of multi-dimensional datasets Methods, systems and computer program products for estimating changes in an object represented by first and second multidimensional datasets. The first dataset is a reference dataset and the second dataset is an altered dataset. Discrete data samples of the first da...	05/24/2011
7947079	Method and system for fusing a spinal region A method and system for fusing a region in the spine involve the use of at least one guide tube to pass instruments and substances into the spinal region in a minimally invasive manner. In the preferred practice of the method, a guide tube is anchored to a vertebra ...	05/24/2011
7947026	Glans compatible single unit semen collection and storage device, kit and related methods of use A method and device to conform with the glans penis to recover ejaculated semen completely, to prevent the loss of initial sperm rich epididymal fractions, to avoid the use of a condom for masturbation, to eliminate the multi-step transfers of semen following ejacul...	05/24/2011
7932227	Lacritin-syndecan fusion proteins The present invention relates to methods and compositions useful for the regulation of lacritin, syndecan, and lacritin-syndecan interactions and the signaling pathway downstream of lacritin-syndecan interactions. The invention also relates to regulating lacritin-sy...	04/26/2011
7932084	Methods and compositions for growing adipose stem cells The present invention relates to adipose tissue-derived stem cells and to methods and compositions for enhancing growth and differentiation of such cells. The invention further relates to growing such cells in serum-free or low serum growth medium, and formulations ...	04/26/2011
7915315	Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity Benzocycloheptyl analogs that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at S1P receptors. ...	03/29/2011
7913611	Blast and ballistic protection systems and method of making the same An embodiment provides a protection structure comprising: open cell core structure; a top face sheet coupled to said core structure; a bottom face sheet coupled to said core structure distal from said top face sheet; a projectile arresting layer coupled to said top ...	03/29/2011
7893071	Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic The present invention is directed to novel thalidomide derivative compounds that have activity as anti-angiogenic compounds. More particularly the compounds have the general structure: where R1 is selected from the group consisting of H, halo, alkyl, halo...	02/22/2011
7888935	K-space trajectory estimation in spiral MRI system and related method thereof First, benchmark data are collected on two thin slices of an object to get measured k-space trajectories. To find delays on different physical gradients, the root mean square error between estimated and measured k-space trajectories is minimized for different delays...	02/15/2011
7888527	Aryl amide sphingosine 1-phosphate analogs The present invention provides compounds that have antagonist activity at the S1P1 and/or S1P3 receptors. These compounds have enhanced selectivity and potency at the S1P1 and/or S1P3 receptors. ...	02/15/2011
7879411	Method and apparatus for efficient application of substrate coating A direct vapor deposition (DVD) method and apparatus for applying coating(s) on substrate(s), including: presenting at least one of the substrates to a chamber, presenting at least one evaporant source (125) in crucible (110) to the chamber; presenting...	02/01/2011
7875604	Compounds that inhibit HIV particle formation The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and compounds for inhibiting HIV particle formation and or treating patients inf...	01/25/2011
7875595	2-polycyclic propynyl adenosine analogs having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein. ...	01/25/2011
7874985	Method, system, and computer program product for the evaluation of glycemic control in diabetes from self-monitoring data A method, system, and computer program product related to the diagnosis of diabetes, and is directed to predicting the long-term risk of hyperglycemia, and the long-term and short-term risks of severe hypoglycemia in diabetics, based on blood glucose readings collec...	01/25/2011
7871978	Bone tropic peptides The present invention is directed to the use of bone tropic peptides identified through the use of a phage display library. More particularly, the invention is directed to compositions comprising the bone tropic peptides and methods for using such compositions to re...	01/18/2011
7858087	Enhancing the efficacy of immunotherapies by supplementing with complement The present invention is directed to a composition and method for enhancing the complement-mediated cytotoxicity of therapeutic antibodies for their target cells (i.e. those cells displaying the target epitope). More particularly the present invention enhances the e...	12/28/2010

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Assignee: University of Virginia Patent Foundation