Assignee: University of Tennessee Research Corporation

Location: Knoxville, TN
No. of patents: 90

Number	Title	Issue Date
7344700	Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy Provided is a class of radiolabeled androgen receptor targeting agents (ARTA), useful for prostate cancer imaging and in treating or preventing prostate cancer. The agents define a new-subclass of radiolabeled compounds, which are selective androgen receptor modulat...	03/18/2008
7169942	Cannabinoid derivatives, methods of making, and use thereof 1′-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having ac...	01/30/2007
7160547	Streptococcal streptolysin S vaccines Provided are streptolysin S (SLS) polypeptides, peptides, and variants thereof, antibodies directed thereto, and isolated nucleic acids encoding such proteins. In one embodiment, a method is provided wherein a synthetic peptide of SLS is used to elicit an immune res...	01/09/2007
7129377	Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen receptor. ...	10/31/2006
7105832	Composite solid-state scintillators for neutron detection Applicant's present invention is a composite scintillator for neutron detection comprising a matrix material fabricated from an inorganic sol-gel precursor solution homogeneously doped with a liquid scintillating material and a neutron absorbing material. The neutro...	09/12/2006
7097662	In-vivo orthopedic implant diagnostic device for sensing load, wear, and infection A device for providing in vivo diagnostics of loads, wear, and infection in orthopedic implants having at least one load sensor associated with the implant, at least one temperature sensor associated with the implant, at least one vibration sensor associated with th...	08/29/2006
7074416	Antigen of hybrid M protein and carrier for group A streptococcal vaccine Recombinant hybrid streptococcal M protein antigens are provided which elicit protective antibodies against Group A streptococci and prevent rheumatic fever. Recombinant hybrid genes which encode the antigen are provided. Vaccine compositions and methods of administ...	07/11/2006
7067321	Polyglutamine repeat sequences Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study the processes of these diseases, including methods for solubilizing po...	06/27/2006
7063850	Protective antigen of group A The present invention provides the discovery of a new Streptococcus protective antigen (herein designated Spa) which has been identified and isolated from Streptococci. Spa is a surface antigen distinct from M protein which evokes opsonic antibodies that are ...	06/20/2006
7041859	Method for halogenating or radiohalogenating a chemical compound A method for obtaining a halogenated organic compound, whereby an organotrifluoroborate compound is reacted with a halide ion in the presence of an oxidizing agent to produce the corresponding halogenated organic compound. The method may be used for producing radioh...	05/09/2006
7026500	Halogenated selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a...	04/11/2006
7022870	N-bridged selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a...	04/04/2006
7020560	Methods for cell-based combinatorial logic A method for cell-based combinatorial logic includes the steps of providing at least one genetically engineered cell, the genetically engineered cell having at least one transcriptional unit. The transcriptional unit includes a gene and a promoter, wherein applicati...	03/28/2006
6998500	Selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a...	02/14/2006
6967067	Patterning methods and systems using reflected interference patterns A method for patterning a layer on a substrate can include projecting coherent radiation toward a reflector surface so that the coherent radiation is reflected off the reflector surface to provide a holographic projection of a desired image wherein the reflector sur...	11/22/2005
6960346	Vehicles for delivery of biologically active substances A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administratio...	11/01/2005
6951935	Heteroatom-substituted porphyrins and methods for synthesis of same Novel methods of synthesizing heteroatom-containing porphyrins and metalloporphyrins are disclosed. Novel heteroatom-containing porphyrin and metalloporphyrin compounds are also disclosed. The new methods advantageously utilize metal-catalyzed cross-coupling and ami...	10/04/2005
6936637	Prevention of apoptosis in non-cancerous cells Treatment of normal, non-cancerous, animal cells with an agent that depletes polyamines within the cells results in an inhibition of apoptosis when the cells are exposed to an inducer of apoptosis. This inhibition of apoptosis is not observed, or is observed to a le...	08/30/2005
6916852	Method for regulation of microvascular tone Methods and kits for regulating arterial microvascular tone in which a COX-2 inhibitor and a cannabinoid receptor agonist are co-administered to a subject. ...	07/12/2005
6875757	LPA receptor agonists and antagonists and methods of use The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA...	04/05/2005
6855536	Materials and methods for the enhancement of effective root nodulation in legumes The subject invention relates to compounds and compositions which induce transcripts of the nolA gene in nitrogen-fixing bacteria, such as Bradyrhizobium japonicum. Novel bacterial strains which are insensitive too NolA, soil inoculants comprising NolA insens...	02/15/2005
6838484	Formulations comprising selective androgen receptor modulators The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents defi...	01/04/2005
6835812	Human p-Hyde proteins This invention provides isolated nucleic acids of the rat and human p-Hyde gene, analogs, fragments, mutants and variants thereof of the p-Hyde family. The invention provides polypeptides, fusion proteins, chimerics, fusion proteins, antisense molecules, antibodies,...	12/28/2004
6730443	Patterning methods and systems using reflected interference patterns A method for patterning a layer on a substrate can include projecting coherent radiation toward a reflector surface so that the coherent radiation is reflected off the reflector surface to provide a holographic projection of a desired image wherein the reflector sur...	05/04/2004
6716433	Group a streptococcal vaccines The present invention provides immunogenic synthetic fusion polypeptide which stimulates an immune response against a selected pathogen, comprising at least two immunogenic polypeptides from a Group A streptococci of at least 10 amino acids in length which are capab...	04/06/2004
6497985	Method for marking steel and aluminum alloys The present invention relates to a method for marking metallic alloys using laser alloying. Specifically, the present invention is directed toward the use of laser alloying steel or aluminum alloys with a mark that provides protection against wear and cor...	12/24/2002
6475754	Polynucleotides encoding Bordatella bronchiseptica fimbrial proteins (FimN), vectors, and expression systems therefor In one aspect, the subject invention concerns the cloning and characterization of a previously unidentified gene, provisionally named fim N, encoding a fimbrial protein that is putatively involved in the attachment of B. bronchiseptica to respiratory epit...	11/05/2002
6423270	Flow cytometric characterization of amyloid fibrils A method of detecting amyloid fibrils in biological samples utilizing flow cytometry is described. It has been found that the measurement of fluorescence from amyloidophilic dyes, such as thioflavin T and Congo red, as well as side scatter and forward sca...	07/23/2002
6419932	Antigen of hybrid M protein and carrier for Group A streptococccal vaccine Recombinant hybrid streptococcal M protein antigens are provided which elicit protective antibodies against Group A streptococci and prevent rheumatic fever. Recombinant hybrid genes which encode the antigen are provided. Vaccine compositions and methods ...	07/16/2002
6384087	Materials and methods for the treatment or prevention of obesity The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is pr...	05/07/2002
6368790	cDNA encoding P2P proteins and use of P2P cDNA derived antibodies and antisense reagents in determining the proliferative potential of normal, abnormal, and cancer cells in animals and humans Terminal differentiation is associated with repression in the expression of the P2P subset of hnRNP proteins. The present invention provides a P2P cDNA that encodes proteins with domains for hnRNP association and Rb1 binding. Probes to the P2P cDNA detect...	04/09/2002
6328467	Method and apparatus for detecting ice or frost deposition A method and system for detecting the presence of a frozen deposition at an interface between a substrate of known thermophysical properties and surroundings of unknown thermophysical properties. The system involves applying a predetermined quantity of he...	12/11/2001
6271202	Reduction of impairment of respiratory tract mucosal immunity The present invention describes methods for reducing the impairment respiratory tract mucosal immunity associated with a lack of enteral feeding or a lack of immunological stimulation of the gastrointestinal tract comprising administering a therapeuticall...	08/07/2001
6251280	Imprint-coating synthesis of selective functionalized ordered mesoporous sorbents for separation and sensors The present invention relates generally to mesoporous sorbent materials having high capacity, high selectivity, fast kinetics, and molecular recognition capability. The invention also relates to a process for preparing these mesoporous substrates through ...	06/26/2001
6245572	Flow cytometric characterization of amyloid fibrils A method of detecting amyloid fibrils in biological samples utilizing flow cytometry is described. It has been found that the measurement of fluorescence from amyloidophilic dyes, such as thioflavin T and Congo red, as well as side scatter and forward sca...	06/12/2001
6167748	Capacitively readout multi-element sensor array with common-mode cancellation An improved multi-element apparatus for detecting the presence of at least one chemical, biological or physical component in a monitored area comprising an array or single set of the following elements: a capacitive transducer having at least one cantilev...	01/02/2001
6127185	Instrument and method for measurement of stability of oils The present invention relates to an instrument and methods for determining stability of oils and fats. The instrument includes a sample reaction vessel for containing a sample of an oil or fat, a moisturized gas source operably connected to the vessel for...	10/03/2000
6063386	Recombinant multivalent M protein vaccine A recombinant multivalent hybrid protein vaccine against multiple serotypes of group A streptococci that may result in rheumatic fever. The vaccine can also evoke other protective antibodies of the mucosal type DNA sequences e.g. genes which encode the ne...	05/16/2000
5786166	Methods for determining effects of a compound on the activity of bacterial periplasmic oxidoreductase enzymes A screening method to determine whether a chemical inhibits the function of a class of bacterial periplasmic oxidoreductase enzymes, exemplified by TcpG of Vibrio cholerae, DsbA E. coli, and Por of Haemophilus influenzae, id disclosed....	07/28/1998
5744139	Insulin-like growth factor I (IGF-1) induced improvement of depressed T4/T8 ratios A method for increasing the T4/T8 ratio in a human with a depressed T4/T8 ratio comprising administering insulin-like growth factor I (IGF-1) is disclosed....	04/28/1998

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Assignee: University of Tennessee Research Corporation