Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 8158409 | Nanoscale surface plasmonics sensor with nanofluidic control A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing fluid handling manifolds that control the flow of fluid through the ar... | 04/17/2012 |
| 8110217 | Sphingomyelin liposomes for the treatment of hyperactive bladder disorders The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pai... | 02/07/2012 |
| 8029774 | Wound healing polymeric networks A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization af... | 10/04/2011 |
| 7993672 | Stable lipid-comprising drug delivery complexes and methods for their production Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the p... | 08/09/2011 |
| 7981448 | Methods of treating necrotizing enterocolitis The present invention relates to a method of treating necrotizing enterocolitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient. ... | 07/19/2011 |
| 7882909 | Personal vehicle A personal vehicle comprises a frame with a seat, two large, non-drive wheels connected by an axle at one end of the frame, an elongated swing arm attached to the axle, a pair of caster wheels connected to the frame opposite the large, non-drive wheels and a main dr... | 02/08/2011 |
| 7867752 | Method and apparatus for holding cells The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be... | 01/11/2011 |
| 7854920 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds.... | 12/21/2010 |
| 7838251 | Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-g... | 11/23/2010 |
| 7806589 | Bi-plane X-ray imaging system A high-speed biplane radiography system for in-vivo assessment of joint function is provided. The system can acquire stereo-pair radiographic images at rates from 30-4000 frames per second of nearly any motion or joint. The radiographic equipment can be mounted in a... | 10/05/2010 |
| 7655468 | Stable lipid-comprising drug delivery complexes and methods for their production Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the p... | 02/02/2010 |
| 7585640 | Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells. ... | 09/08/2009 |
| 7560538 | Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region The present invention provides porcine isogloboside 3 (iGb3) synthase protein, cDNA, and genomic DNA regulatory sequence. The present also invention includes porcine animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and org... | 07/14/2009 |
| 7531634 | Bladder matrix protein peptides and methods of detection of bladder cancer Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also... | 05/12/2009 |
| 7527634 | Device and method of use for functional isolation of animal or human tissues A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with ... | 05/05/2009 |
| 7521504 | Irreversible immobilization of enzymes into polyurethane coatings A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irrever... | 04/21/2009 |
| 7456383 | Surface plasmon-enhanced nano-optic devices and methods of making same A nanostructured optical device includes a metal film or a plurality of metal islands having an array of a plurality of openings having a width that is less than at least one first predetermined wavelength of incident radiation to be provided onto the film or the is... | 11/25/2008 |
| 7429481 | Targeting viruses using a modified sindbis glycoprotein The present invention relates to viruses that are engineered to contain a surface ligand molecule which targets the virus to a cell of interest. In particular non-limiting embodiments, the cell of interest is desirably ablated and may be a cancer cell, an infected c... | 09/30/2008 |
| 7426040 | Chip-scale optical spectrum analyzers with enhanced resolution A Fabry-Perot cavity filter includes a first mirror and a second mirror. A gap between the first and the second mirror monotonically varies as a function of width of the filter. This filter may be used with photodetector and a channel selection filter in an optical ... | 09/16/2008 |
| 7420156 | Metal nanowire based bandpass filter arrays in the optical frequency range A metal nanowire array acts as a band pass filter in the visible to IR range. The filter may be used in a monochromator, spectrometer, color camera, analyte detector or other devices. ... | 09/02/2008 |
| 7368284 | Porcine CMP-N-Acetylneuraminic acid hydroxylase gene The present invention provides porcine CMP-N-Acetylneuraminic-Acid Hydroxylase (CMP-Neu5Ac hydroxylase) protein, cDNA, and genomic DNA regulatory sequences. Furthermore, the present invention includes porcine animals, tissues, and organs, as well as cells and cell l... | 05/06/2008 |
| 7361517 | Real time method of detecting acute inflammatory conditions This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this act... | 04/22/2008 |
| 7361640 | Stable lipid-comprising drug delivery complexes and methods for their production Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the p... | 04/22/2008 |
| 7358869 | Power efficient, high bandwidth communication using multi-signal-differential channels A low-power, area and pin efficient signaling alternative to serial differential links used for chip-to-chip, backplane, optical and other signaling applications. The multi-bit differential signaling (MBDS) generally comprises a driver and link termination network d... | 04/15/2008 |
| 7351401 | Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds.... | 04/01/2008 |
| 7336357 | Multi-channel dual phase lock-in optical spectrometer The development of a multiple-channel dual phase lock-in optical spectrometer (LIOS) is presented, which enables parallel phase-sensitive detection at the output of an optical spectrometer. The light intensity from a spectrally broad source is modulated at the refer... | 02/26/2008 |
| 7335679 | Wortmannin analogs and methods of using same Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein. ... | 02/26/2008 |
| 7335400 | Irreversible immobilization of enzymes into polyurethane coatings A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irrever... | 02/26/2008 |
| 7335509 | Stable lipid-comprising drug delivery complexes and methods for their production Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the p... | 02/26/2008 |
| 7321830 | Identifying drugs for and diagnosis of benign prostatic hyperplasia using gene expression profiles The present invention relates to a computer system comprising a database for elucidating changes in gene expression in prostate tissue isolated from patients exhibiting different clinical states of prostate hyperplasia as compared to normal prostate tissue, as well ... | 01/22/2008 |
| 7321046 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediate... | 01/22/2008 |
| 7315426 | Metallic nano-optic lenses and beam shaping devices A nano-optic device comprises a plurality of subwavelength apertures in a metal film or between metal islands. The device is adapted to shape a radiation beam transmitted there through. For example, beam shaping includes at least one of beam focusing, beam bending a... | 01/01/2008 |
| 7296361 | Measuring device and method of measuring a device for measuring dimensions in a hollow organ of the body, includes: a length of conduit; a measuring mechanism on one end of the conduit; and an indicator in connection with a second end of the conduit. The indicator is in operative connection with the measur... | 11/20/2007 |
| 7270800 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds.... | 09/18/2007 |
| 7271159 | Camptothecin analogs and methods of preparation thereof The present invention provides generally a compound having the following general formula (1): wherein R1 and R2 are independently the same or different and are hydrogen, an alkyl group, an a... | 09/18/2007 |
| 7264948 | Polypeptides for increasing mutant CFTR channel activity The present invention provides methods and compositions for enhancing channel activity to the mutant cystic fibrosis trans-membrane conductance regulator protein (CFTR). The compositions of the invention comprise polypeptides containing CFTR sub-domains that are des... | 09/04/2007 |
| 7264823 | Medical adhesive and methods of tissue adhesion An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary a... | 09/04/2007 |
| 7258991 | Antibody to bladder cancer nuclear matrix protein and its use Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also... | 08/21/2007 |
| 7220860 | Camptothecin analogs and methods of preparation thereof A compound has the formula in racemic form, enantiomerically enriched form or enantiomerically pure form. R6 is preferably —Si(R8R9R10) or —(R7)Si(R... | 05/22/2007 |
| 7206633 | Device and method to discriminate between supraventricular tachycardias and ventricular arrhythmias A method discriminates between ventricular arrhythmia and supraventricular tachycardia by detecting an earliest arriving electrical signal following anti-tachycardia pacing. An implantable cardiac defibrillator provides simultaneous atrioventricular anti-tachycardia... | 04/17/2007 |
