Assignee: University of Medicine and Dentistry of New Jersey

Location: New Brunswick, NJ
No. of patents: 52

Number	Title	Issue Date
8183011	RNA interferases and methods of use thereof The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase...	05/22/2012
7989604	Dispersin B polynucleotides and methods of producing recombinant DspB polypeptides Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies...	08/02/2011
7846683	Method for identifying agents which modulate cell growth or survival The present invention relates to a method for identifying an agent. for modulating cell growth or survival. The method involves the identification of an agent which modulates the net ratio of nuclear-localized versus cytosolic-localized H11 kinase or mutant H11 kina...	12/07/2010
7833523	Compositions and methods for enzymatic detachment of bacterial and fungal biofilms Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies...	11/16/2010
7811803	Methods and compositions for rapid purification of proteasomes and methods of use of components thereof Disclosed are methods for rapidly and efficiently purifying proteasomes using fusion proteins having homology to ubiquitin. Also disclosed are methods for assessing aberrant cell growth utilizing fusion proteins have homology to ubiquitin and a signal producing moie...	10/12/2010
7807462	Method for producing a functional neuron The present invention relates to the production of functional neurons from adult human mesenchymal stem cells using a retinoid. A retinoid, when used in the absence of a growth factor, transdifferentiates mesenchymal stem cells into functional neurons that exhibit s...	10/05/2010
7803908	pDJA1, a cardiac specific gene, corresponding proteins, and uses thereof The present invention provides novel nucleic acid and protein sequences for methods and compositions for treating, screening, and diagnosing cardiovascular disease and methods for using these genes and gene products for prevention of cardiac cell death and preventio...	09/28/2010
7790155	Calbindin-Dprotection against glucocorticoid induced cell death The present invention provides novel compositions containing a calbindin-D28k therapeutic element, which is involved in the regulation of apoptosis, and may be administered for the prevention of an abnormal apoptosis response in cells. In particular the c...	09/07/2010
7785878	Mammalian alpha-kinase proteins, nucleic acids and diagnostic and therapeutic uses thereof The present invention provides novel mammalian alpha-kinase proteins: melanoma alpha-kinase (MK), heart alpha-kinase (HK), kidney alpha-kinase (KK), skeletal muscle alpha-kinase (SK), and lymphocyte alpha-kinase (LK). In particular, a novel kinase type is herein pro...	08/31/2010
7763582	Localized insulin delivery for bone healing A method of promoting bone healing in a non-diabetic patient in need thereof by locally administering a therapeutically effective amount of insulin to the patient. A drug delivery device, which includes insulin and a pharmaceutically acceptable carrier, wherein the ...	07/27/2010
7598238	Fluorescent fused-ring traizoles that inhibit cell proliferation and uses thereof Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infectio...	10/06/2009
7450687	Method for verification of intensity modulated radiation therapy An accurate method for inversely verifying a therapeutic radiation dose delivered to a patient via an x-ray delivery system without involving any computational iteration was developed. The usage of it includes detecting the transmitted radiation dose image after pas...	11/11/2008
7429654	Cold-shock regulatory elements, constructs thereof, and method of use Regulatory elements of the 5′UTR of cold-shock inducible genes that prolong the expression of cold-shock inducible genes under conditions that elicit the cold-shock response in a bacterium, repress the expression of the cold-shock inducible genes under physiologic...	09/30/2008
7427486	Mullerian inhibiting substance levels and ovarian response Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively correlated with the production and retrieval of mature oocytes and ser...	09/23/2008
7373597	Conversion of text data into a hypertext markup language Disclosed is a markup system and method for converting text-based guidelines into a form that allows manipulation and viewing in different formats and detail. The system identifies conditions described in electronic documents and uses an interactive or rule-based pr...	05/13/2008
7364921	Method and apparatus for separating biological materials and other substances A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands capable of binding to the desired and/or the undesired components to form a...	04/29/2008
7341867	Human preprotachykinin gene promoter Compositions and methods are provided for identifying novel therapeutic agents for the treatment of breast cancer, bone marrow metastasis, pain, arthritis, aggressive behavior, depression, and certain hematopoietic disorders. Disclosed are promoters and 3′ regulat...	03/11/2008
7294497	Compositions and methods for enzymatic detachment of bacterial and fungal biofilms Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies...	11/13/2007
7285630	Tropomyosin isoforms, and diagnostic and therapeutic uses therefor A novel isoform of tropomyosin is disclosed. The isoform is closely related to epithelial human tropomyosin (hTM) and more particularly to hTM5 except the last coding exon. The novel isoform, is called TC22. Northern blot analysis with TC22-specific probe revealed t...	10/23/2007
7264807	Treatment of ulcerative colitis with tropomyosin isoforms and monoclonal antibodies to tropomyosin isoforms This invention pertains to a method for treating ulcerative colitis. Specifically, the method comprises orally or rectally administering to a human having ulcerative colitis a therapeutically effective amount of an antibody which binds to a tropomyosin isoform assoc...	09/04/2007
7244814	Variant Tat proteins and methods for use thereof Variants of the HIV-1 Tat protein exhibiting higher transcriptional activation and stronger P-TEFb binding than wild-type Tat are provided. In addition variants that can inhibit transcription activation by wild-type Tat are provided. Nucleic acid sequences encoding ...	07/17/2007
7241577	Mullerian inhibiting substance levels and ovarian response Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively correlated with the production and retrieval of mature oocytes and ser...	07/10/2007
7214771	Nucleic acid and protein expression thereby and their involvement in stress The present invention pertains to a novel BTB-POZ domain zinc finger protein, which is named herein RIα-associated zinc finger (RIAZ). The nucleic acid and corresponding protein products have been identified, as have numerous diagnostic and therapeutic utilities pr...	05/08/2007
7198909	Myeloid precursor cell useful for gene therapy and for modulation of immune responses A long-lived, myeloid-committed stem cell population is disclosed. Also disclosed are methods and compositions for targeting this population with retrovirus vectors in gene therapy protocols for correcting congenital disorders of myeloid system and for potentiating ...	04/03/2007
7160859	Mst1 modulation of apoptosis in cardiac tissue and modulators of Mst1 for treatment and prevention of cardiac disease The present invention relates to methods and agents for treatment, amelioration and prevention of cardiac disease, including cardiac myopathy, chronic heart failure and for management and reduction of cardiac myocyte death which may occur in response to ischemia/rep...	01/09/2007
7150967	Fluorescent tags for amino acid and nucleic acid analysis Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are highly reactive with thiol containing species are provided. Fluoresce...	12/19/2006
7141589	Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.	11/28/2006
7122336	Therapeutic and diagnostic methods for ulcerative colitis and associated disorders This invention relates to the field of therapy and diagnostic methods for ulcerative colitis. Specifically, the method comprises administering a compound or recombinant protein that inhibits interaction between CEP and human tropomyosin. Also included in the inventi...	10/17/2006
7119071	Amino terminal substance P compositions and methods for using the same The present invention establishes the fact that the degradation of SP to SP(1-4) by endogenous NEP in BM stroma can be a mediator of hematopoietic stimulation by stem cell factor (SCF) and induce the production of TGF-β and TNF-α in BM stroma. The present inventio...	10/10/2006
7105511	Fluorescent fused-ring triazoles that inhibit cell proliferation and uses thereof Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infectio...	09/12/2006
7097984	Method of utilizing neurotrophins to manipulate reproductive capacity Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a...	08/29/2006
7087427	Mammalian alpha-kinase proteins, nucleic acids and diagnostic and therapeutic uses thereof The present invention provides novel mammalian alpha-kinase proteins: melanoma alpha-kinase (MK), heart alpha-kinase (HK), kidney alpha-kinase (KK), skeletal muscle alpha-kinase (SK), and lymphocyte alpha-kinase (LK). In particular, a novel kinase type is herein pro...	08/08/2006
7056656	Tat-derived oligourea and its method of production and use in high affinity and specific binding HIV-1 TAR RNA This invention relates to the use of oligourea molecules to specifically inhibit protein-nucleic acid interactions. In particular, it provides an oligourea molecule that competes with the Tat molecule for the TAR RNA of HIV-1. Also provided is a method specifically ...	06/06/2006
7045134	Borellia burgdorferi epitope peptides Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay. ...	05/16/2006
7033996	Method for the treatment of vitamin D related disease The present invention provides a method for treating diseases caused by either an excess or diminution of Vitamin D3. It provides pharmaceutical compositions for the treatment of such diseases and the methods by which these compositions are to be used. Al...	04/25/2006
7033832	Endothelial cell—cell cohesion Methods for stably populating solid surfaces, especially those of biomedical devices, with cells; also the resulting cell-coated surfaces. ...	04/25/2006
7029846	Site-specific protein modification Site-specific modified proteins and method for producing site-specific modified proteins using amino acid analogs are disclosed. Methods for labeling proteins at a desired site in the presence of nucleophilic side chains, including lysine and cysteine side chains, a...	04/18/2006
7015022	Mammalian catalase-dependent oxidation processes and methods for stimulating oxidative activities A catalase-dependent enzymatic oxidation process wherein a substrate to be oxidized is contacted with catalase in the absence of hydrogen peroxide is provided. Also provided are methods for using this process in a variety of biomedical, clinical and diagnostic appli...	03/21/2006
7008387	Portable device for collecting information about living body A portable device for collecting information about a human body is adapted to be worn on the human body and is capable of periodically performing cognitive faculty tests during daily life to discern fluctuations in the memory faculty of a wearer. The device displays...	03/07/2006
6989256	Subfamily of RNA helicases which are modulators of the fidelity of translation termination and uses thereof An isolated multiprotein complex of S. cerevisiae components is provided that is effective to modulate peptidyl transferase activity during translation. This complex includes a Modulator of Translation Termination protein (Mtt1p, also referred to as helicase ...	01/24/2006

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Assignee: University of Medicine and Dentistry of New Jersey