Assignee: University of Massachusetts Medical Center

Location: Worcester, MA
No. of patents: 65

Number	Title	Issue Date
7850956	Immunization by inoculation of DNA transcription unit This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in th...	12/14/2010
7722874	Methods for reducing T cell responsiveness to an autoantigen with anti-gp39 antibodies and antigen presenting cells Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates con...	05/25/2010
7387882	Predictive assay for immune response The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method ...	06/17/2008
7330531	System for quantitative radiographic imaging A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a ...	02/12/2008
6962790	Predictive assay for immune response The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method ...	11/08/2005
6895077	System and method for x-ray fluoroscopic imaging A system for x-ray fluoroscopic imaging of bodily tissue in which a scintillation screen and a charge coupled device (CCD) is used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray...	05/17/2005
6841381	Immunization by inoculation of DNA transcription unit This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in th...	01/11/2005
6717174	System for quantitative radiographic imaging A system for imaging of bodily tissue in which an x-ray source, an optical storage element, a light source and a detector array are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an...	04/06/2004
6627407	Predictive assay for immune response The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, ...	09/30/2003
6445767	System for quantitative radiographic imaging A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming ...	09/03/2002
6375950	Methods for inducing T cell unresponsiveness to donor tissue or organ in a recipient with gp39 antagonists Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell...	04/23/2002
6271205	Cancer treatment by expression of differentiation factor receptor Disclosed are methods of reducing or inhibiting the motility and/or proliferative abilities of a neural tumor cell, or of enhancing apoptosis or differentiation of the tumor cell, in which a vector comprising a nucleic acid encoding a cytoplasmic domain o...	08/07/2001
6221841	General receptors for phosphoinositides and uses related thereto The present invention relates to the discovery of a novel isoform of phosphatidylinositide binding protein, referred to herein a "general receptors for phosphoinositides" or "GRPs". The GRP molecules show a modular structure comprising a domain homologous...	04/24/2001
6177437	Inhibitors of Herpes Simplex virus uracil-DNA glycosylase The invention is directed to novel 6-aromatic substituted uracil compounds of formula I ##STR1## therapeutic compositions comprising the compounds, and methods of treating Herpes simplex virus Type I and Type II recurrent infections and Herpes simple...	01/23/2001
6165993	DNA vaccines against rotavirus infections This invention relates to methods of eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate a DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e.g., capsid proteins or polyp...	12/26/2000
6051373	Methods for screening for inhibitors of the transcription-enhancing activity of the X protein of hepatitis B virus Disclosed is a method for screening for inhibitors of Hepatitis B Virus pX activity. The method involves contacting a test compound with (I) the pX protein of HBV, (ii) a transcription factor comprising the bZIP domain, or fragments that comprise a minima...	04/18/2000
6031892	System for quantitative radiographic imaging A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming ...	02/29/2000
5989893	Receptor-activated reporter systems The invention discloses a chimeric GLUT transporter including a GLUT receptor polypeptide fused to a domain of a detectable heterologous polypeptide and cells expressing such reporter constructs. Cells expressing a detectably-tagged chimeric GLUT transpor...	11/23/1999
5935776	Small molecule inhibition of RNA/ligand binding Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemp...	08/10/1999
5902585	Methods of inducing T cell unresponsiveness to donor tissue or organ in a recipient with GP39 antagonists Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell...	05/11/1999
5895747	Inhibition of tax-mediated increase in DNA binding The Tax protein of Human T Cell Leukemia Virus Type 1 (HTLV-I) transcriptionally activated the HTLV-I promoter through binding sites for ATF, a family of cellular bZIP transcription factors. In this disclosure, it is reported that Tax dramatically increas...	04/20/1999
5882650	Cross-reactive influenza A immunization This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective response which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the individual ...	03/16/1999
5869049	Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which m...	02/09/1999
5864146	System for quantitative radiographic imaging A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming ...	01/26/1999
5849520	Post transcriptional gene regulation by selenium Methods of controlling the in vivo and in vitro expression of a heterologous protein by transfecting a cell with a first nucleic acid encoding the heterologous polypeptide, wherein at least one codon of mRNA transcribed from the first nucleic acid is repl...	12/15/1998
5847077	Fungal multisubunit protein complex critical for expression of fungal proteins The present invention provides a complex of fungal polypeptides, termed TAFs, that are necessary for activated transcription in fungi such as S. cerevisiae. The complex comprises at least nine associated subunit polypeptides, having molecular masses of ab...	12/08/1998
5766601	Cross-reactive influenza a immunization This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective response which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the individual ...	06/16/1998
5737456	Method for image reconstruction A method for processing a digitized image is described. The method includes the step of first generating a digitized image using an image-measuring system and representing the image as a vector g. A point spread function (PSF), represented as the function...	04/07/1998
5728527	Detection of hybridized oligonocleotide probes in living cells A method of nucleic acid hybridization in living cells is described, which is useful for detecting, quantitating and locating a specific nucleic acid in a cell or tissue, for selecting cells based on the expression or presence of a specific nucleic acid, ...	03/17/1998
5723300	Nuclear localized transcription factor kinase and diagnostic assays related thereto New nuclear kinases that are regulated by signal transduction and that participate in phosphorylation cascades which regulate transcription and related methods for regulating transcription. The novel nuclear kinases play a vital role in gene expression, p...	03/03/1998
5715292	Digital sensor cassette for mammography A CCD-scintillator x-ray image sensor (18) has a high sensitivity at room temperature and a low profile, enabling the use of the x-ray image sensor in most modern mammography x-ray machines. A cassette 10 that encloses the CCD-based x-ray image sensor has...	02/03/1998
5712096	Oligoribonucleotide assays for novel antibiotics The oligoribonucleotide analogs of the invention are relatively small, three-dimensional structures derived from larger parental RNA molecules. The analogs include a first nucleic acid structure including one or more nucleotide sequences that are derived ...	01/27/1998
5700660	Positional control of selenium insertion in polypeptides for X-ray crystallography The invention provides methods for determining the structure of a polypeptide by a) transfecting a cell with (i) a first nucleic acid encoding the polypeptide, wherein at least one, specific codon of mRNA transcribed from the first nucleic acid is replace...	12/23/1997
5683693	Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 Methods for inducing T cell unresponsiveness to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on t...	11/04/1997
5679566	Yeast NMD2 gene The invention relates to the discovery of a gene, NMD2, named after its role in the Nonsense-Mediated mRNA Decay pathway, and the protein, Nmd2p, encoded by the NMD2 gene. The amino acid sequence of Nmd2p and the nucleotide sequence of the NMD2 gene encod...	10/21/1997
5674502	Cross-reactive influenza a immunization This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective response which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the individual ...	10/07/1997
5665350	Cell cycle dependent transplantation and ex vivo gene therapy Methods for the enhancement of bone marrow stem cell engraftment are provided for use in transplantation therapy and ex vivo gene therapy of a mammal. The methods involve the transplantation of quiescent stem cells for transplantation therapy and quiescen...	09/09/1997
5646155	Drugs to prevent recurrent herpes virus infections N2 -substituted alkylguanine and N2 -substituted phenylguanine compounds which prevent recurrent herpes simplex infections are disclosed. By virtue of their ability to inhibit herpes virus thymidine kinase in vivo, such compounds wil...	07/08/1997
5643578	Immunization by inoculation of DNA transcription unit This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate re...	07/01/1997
5641675	Cis-acting sequences for intracellular localization of RNA Disclosed are the particular 3' noncoding nucleotide sequences (zipcode and zipcode elements) that cause ଲ-actin mRNA (and ଲ-actin protein synthesis) to be localized in specific regions of the cytoplasm. Also disclosed is the discovery that zi...	06/24/1997

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Assignee: University of Massachusetts Medical Center