Assignee: University of Massachusetts

Location: Worcester, MA
No. of patents: 26

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Number	Title	Issue Date
7981495	Materials methodology to improve the delamination strength of laminar composites Fiber based z-directional reinforced composites having enhanced inter-laminar strength, impact toughness, transmission properties (electrical and thermal conduction) and coefficient of thermal expansion are provided. The composites include at least two substrates se...	07/19/2011
7405342	Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding heterologous CR1 for expression on red blood cells. Methods of using ...	07/29/2008
7175418	Melt control system for injection molding A method and apparatus for proportioning flow and controlling pressure to a gate of an injection mold. The invention decouples the control surface from the gate closure to reduce the required actuation force. Methods for estimating the pressure and flow rate enterin...	02/13/2007
7132258	Nucleic acid encoding vitamin D receptor related polypeptide A new transcriptional co-activator that interacts with steroid/nuclear receptors has been identified. The peptide and its nucleic acid sequences are useful for modulating the activity of steroid/nuclear receptors and biochemical processes in which steroid/nuclear re...	11/07/2006
7045609	Hybrid oligonucleotide phosphorothioates The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of dup...	05/16/2006
6913921	Rapid cell block embedding method and apparatus A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in ...	07/05/2005
6693176	Antitumor antibodies, proteins, and uses thereof Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of such antibodies....	02/17/2004
6683167	Hybrid oligonucleotide phosphorothioates The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properti...	01/27/2004
6573303	Thermoplastic elastomers and polymers derived from recycled rubber and plastics Materials ranging from impact-modified thermoplastics to thermoplastic elastomers (TPE) can be obtained from blends of phase compatibility-treated recycled thermoset rubber with thermoplastic polymers by varying the ratio of components in the blend, or by...	06/03/2003
6573072	Ribozymes having 2'-O substituted nucleotides in the flanking sequences The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain 2'-O-substituted nucleotides. ...	06/03/2003
6564088	Probe for localized tissue spectroscopy An optical probe structure for illuminating and collecting returned light from a region of tissue. The optical probe is configured with illumination and collection windows to controllably collect light from the region of tissue in vivo. The probe is desig...	05/13/2003
6365352	Process to study changes in gene expression in granulocytic cells The present invention comprises a method to identify granulocytic cell genes that are differentially expressed upon exposure to a pathogen or in a sterile inflammatory disease by preparing a gene expression profile of a granulocytic cell population expose...	04/02/2002
6204027	Ribozymes having 2'-O substituted nucleotides in the flanking sequences The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain 2'-O-substituted nucleotides. ...	03/20/2001
6194173	Binding proteins for phosphoinositides, GRP1 or general receptor 1 for phophoinositide Novel phosphatidylinositide binding proteins, referred to herein a "general receptors for phosphoinositides" or "GRPs" are disclosed which are useful as adaptors between membrane signalling and multiple downstream targets. This invention describes isolate...	02/27/2001
6174676	Cytokine-stress- and oncoprotein-activated human protein kinase kinases Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human-MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor...	01/16/2001
6153729	Isolated nuclear matrix targeting peptide Nuclear matrix targeting peptides (NMTPs) capable of delivering a variety of therapeutic and diagnostic agents, such as transcription regulatory factors, to the nuclear matrix of a cell are disclosed....	11/28/2000
6143881	Hybrid oligonucleotide phosphorothioates The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properti...	11/07/2000
6087484	Enhancement of ribozyme catalytic activity by A 2'-O-substituted facilitator oligonucleotide Methods are disclosed for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme and a 2'-O-substituted facilitator oligonucleotide. The present invention further provides com...	07/11/2000
5980861	Chelator compositions and methods of synthesis thereof Compositions of radiolabeled nucleic acids and methods for synthesis and use thereof are disclosed....	11/09/1999
5939254	Methods and reagents for rapid diagnosis of dengue virus infection Specific primers that amplify a portion of the 3'-noncoding regions of dengue virus types 1, 2, 3 and 4, and a method of using these primers in a rapid reverse transcriptase-polymerase chain reaction (RT-PCR) for specific detection of dengue viruses, but ...	08/17/1999
5906579	Through-wall catheter steering and positioning A method of positioning a catheter, for example a balloon or treatment catheter. The catheter is inserted in a passage and sensed through the luminal wall to correctly determine its position. As applied to prevent hemorrhage during surgery the method invo...	05/25/1999
5904147	Intravascular catheter and method of controlling hemorrhage during minimally invasive surgery A catheter, for example a balloon or treatment catheter, is positioned to prevent hemorrhage during surgery by inserting the catheter in a deflated configuration along a passage such as a blood vessel near to the operative site in a position determined by...	05/18/1999
5769794	Tissue retrieval bag and method for removing cancerous tissue A tissue retrieval bag has a wide mouth and folds for insertion through an incision to a body cavity to form a flat tray and receive excised tissue. The tissue is dropped onto the floor of the bag and the mouth of the bag is then drawn back through the in...	06/23/1998
5550047	Oligonucleotides with anti-Epstein-Barr virus activity Disclosed are oligonucleotides complementary to and hybridizable with a portion of the BZLF1 RNA of Epstein-Barr virus, useful for inhibiting the induction of the lytic cycle in EBV-infected cells, and in inhibiting EBV replication....	08/27/1996
5523204	Detection of nucleic acids in cells by strand displacement amplification Strand Displacement Amplification for amplification of nucleic acid target sequences in situ in cells in suspension, on slides or in tissues. Excellent specimen morphology is preserved, and either DNA targets, or RNA targets, or both may be selectively am...	06/04/1996
4744667	Microspectrofluorimeter An accessory is provided to convert a conventional microscope to a microspectrofluorimeter. The accessory includes a filter disc having bandpass filters separated by opaque segments. The filter disc is rapidly and continuously rotated to move the filter s...	05/17/1988

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Assignee: University of Massachusetts