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Assignee: University of Maryland Biotechnology Institute


Location: Baltimore, MD
No. of patents: 67

1    
NumberTitleIssue Date
7850958Recombinant double stranded RNA nucleocapsid and use of the same
A recombinant double stranded RNA (dsRNA) nucleocapsid useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RN...
12/14/2010
7732215Cyanide sensing compounds and uses thereof
The present invention relates to a cyanide detection method using fluorescence and cyanide sensitive boronic acid containing fluorophores, wherein a change in a measured fluorescent property correlates to the concentration of the cyanide compound in a biological or ...
06/08/2010
7728106HIV-1 glycopeptides and derivatives; preparation and applications thereof
A method of making a synthetic glycopeptide, by addition of a synthetic oligosaccharide oxazoline to a GlcNAc-containing peptide precursor in the presence of an enzyme selected from among Endo-A and Endo-M. In a specific implementation, the method is utilized to syn...
06/01/2010
7718804Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids
Quaternary nitrogen heterocyclic boronic acid-containing compounds are described, which are sensitive to glucose and fructose, as well as a variety of other physiologically important analytes, such as aqueous chloride and iodide, and a method of using the compounds....
05/18/2010
7632634Method and assay for early diagnosis of prostate cancer
A method and assay are described for determining prostate cancer and the general stage of progression of such cancer by quantifying levels of expression of different galectin isoforms and/or different levels of promoter methylation of such galectin isoforms. ...
12/15/2009
7604804Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric gp120
The present invention relates to multivalent HIV inhibitors that bind to multiple sites on a trimeric gp120 complex thereby blocking the CD4 binding site on the trimeric gp120 complex and inhibiting the attachment and entry of HIV through gp120-CD4 interactions....
10/20/2009
7569219Recombinant double-stranded RNA phage, and use of the same
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactiv...
08/04/2009
7556806Carbohydrate-based synthetic vaccines for HIV
The present invention relates to a constructed oligosaccharide cluster, optionally bonded to an immunogenic protein, that can be administered to a subject to induce an immune response for increasing production of 2G12 and/or used in assays as reactive sites for dete...
07/07/2009
7524821Scaffolded maleimide clusters for multivalent peptide assembly
Disclosed are scaffolded maleimide clusters, methods of making said clusters and use of said clusters as templates for multivalent peptide assembly. Multiple maleimide functionalities were introduced onto a scaffold molecule by the reaction of a core-centered polyam...
04/28/2009
7491399In Ovo vaccine against infectious bursal disease
The present invention relates to a non pathogenic vaccine comprising a recombinant Infectious Bursal Disease virus that includes a recombinant Segment A, designated as rD78GLSNSĪ”, that includes sequences from D78 and GLS strains and wherein the NS protein is not ex...
02/17/2009
7462480Stimulation of microbial dechlorination of polychorinated biphenyls with halogenated ethenes
Disclosed is a method for the anaerobic microbial dechlorination of polychlorinated biphenyls (PCBs). Polyhalogenated ethenes are used to stimulate the growth and dechlorinating activity of PCB dechlorinating bacteria in a contaminated soil or sediment. This method ...
12/09/2008
7462284Dissimilatory sulfate reduction as a process to promote denitrification in marine recirculating aquaculture systems
The present invention relates to a novel approach for nitrate removal from a marine recirculating system (10) wherein high concentrations of sulfate found in seawater is used in combination with sludge (20) collected from fish growing tanks (12)...
12/09/2008
7407790Recombinant double-stranded RNA phages and uses thereof
The present invention provides recombinant double stranded RNA phages (rdsRP) that express dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phages are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restric...
08/05/2008
7399473Virus coat protein/receptor chimeras and method of use
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties charac...
07/15/2008
7384641Immuno-modulating effects of chemokines in DNA vaccination
The present invention relates to a composition and method for enhancing the efficacy of a vaccine in a subject treated with the vaccine by administering to the subject an antigen in conjunction with a chemokine. ...
06/10/2008
7375404Fabrication and integration of polymeric bioMEMS
A micro-electro-mechanical system (MEMS) device is provided, along with means for its fabrication and operation for microfluidic and/or biomicrofluidic applications. The MEMS device includes a substrate, optional electrodes on the substrate, a patterned structure on...
05/20/2008
7314741Anaerobic ammonium oxidation for water treatment in recirculating aquaculture
Disclosed herein are planctomycetes sp. which convert ammonia to nitrogen under anaerobic conditions, filtration and aquaculture systems comprising said bacteria, filtration media comprising said bacteria, and methods of filtration using said bacteria. ...
01/01/2008
7311920Virus coat protein/receptor chimeras and methods of use
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can interact with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties charact...
12/25/2007
7247432Enhanced protein thermostability and temperature resistance
Small heat shock proteins, e.g., Pyrococcus fuiosus (Pfu-sHSP and/or Pfu-tsHSP), confer thermotolerance on cellular cultures and on proteins in cellular extracts during prolonged incubation at elevated temperature, demonstrating the ability to protect cellula...
07/24/2007
7244432Infectious bursal disease virus (IBDV) variant from Georgia
A VP2 protein isolated from a variant Georgia strain of Infectious Bursal Disease Virus (IBDV) and method of generating such VP2 protein and variant strain for use to reduce or prevent infection in poultry by IBDV. ...
07/17/2007
7194978Inducing sterility in fish by disrupting the development of the GnRH system
The present invention provides for a method for inducing sterility in fish by administering at least one compound that disrupts the establishment of the gonadotropin-releasing hormone system during early development thereby inhibiting sexual maturity in the treated ...
03/27/2007
7138373Polysaccharide-based polymers and methods of making the same
Gels and polymers comprising a polypeptide bound to a polysaccharide are disclosed. Specific polypeptides include, but are not limited to, polypeptides that comprise glutamine or tyrosine residues. Specific polysaccharides include, but are not limited to, chitosan. ...
11/21/2006
7125718Method for introducing and expressing genes in animal cells, and bacterial blebs for use in same
A method for introducing and expressing genes in animal cells, in which the animal cells are transfected with bacterial blebs containing a eukaryotic expression cassette encoding the gene. Bacterial blebs comprising a eukaryotic expression cassette, wherein the bact...
10/24/2006
RE39270Process for continuous optimized protein production in insect larvae
The present invention provides for a recombinant insect larvae and a process of manufacturing proteins utilizing insect larvae that allows for the selection of individual larvae for harvest at the point of their optimal expression of a protein of interest. This inve...
09/05/2006
7082893Aquaculture nitrogen waste removal
The present invention relates to a two-stage biofilter reactor system for removing nitrogenous compounds from a recirculating aquaculture system. The system includes a aerobic nitrification unit and a downstream anaerobic denitrification unit, wherein both units hav...
08/01/2006
7067145Use of arachidonic acid for enhanced culturing of fish larvae and broodstock
A method of enhancing a culturing characteristic of fish larvae, including administering to said larvae in a nutritional diet essential fatty acids including DHA and AA in a ratio effective to enhance the culturing characteristic of such fish larvae relative to a co...
06/27/2006
7033767Genes regulating programmed cell death
The present invention to amino acid sequences of proteins that are associated with apoptosis and the use of these proteins in the diagnosis, prevention and treatment of disorders associated with abnormal cell proliferation and apoptosis. The invention relates as wel...
04/25/2006
6936256Sub-unit vaccine for infectious pancreatic necrosis virus
The present invention relates to sub-unit vaccines comprising structural polypeptides of Infectious Pancreatic Necrosis Virus (IPNV) comprising structural proteins VP2 and VP3 folded as an empty IPNV viral capsid that approximates the size and structural conformatio...
08/30/2005
6919319Immuno-modulating effects of chemokines in DNA vaccination
The present invention relates to a composition and method for enhancing the efficacy of a vaccine in a subject treated with the vaccine by administering to the subject an antigen in conjunction with a chemokine. ...
07/19/2005
6908612Virus coat protein/receptor chimeras and methods of use
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties charac...
06/21/2005
6841345Treatment and prevention of immunodeficiency virus infection by administration of non-pyrogenic derivatives of lipid A
The present inventors have found that certain preparations containing LPS and/or lipid A variants, derivatives, and/or analogs demonstrate non-pyrogenic properties and exhibit anti-viral activities. In particular, non-pyrogenic preparations of LPS, lipid A, LPS anta...
01/11/2005
6805882Therapeutic fractions of sources of HCG
The present invention relates to fractions of sources and or preparations of human chorionic gonadotropin, such as fractions of human early pregnancy urine, which fractions have anti-HIV activity. The present invention further relates to pharmaceutical compositions ...
10/19/2004
6803479Reagents and method for spatio-temporal control of gene expression by illumination
A caged non-steroidal ecdysome memetic (NSE) compound and a method for producing free NSE by subjecting the charged NSE to UV irradiation. ...
10/12/2004
6759195Method of differential display of prokaryotic messenger RNA by RTPCR
The present invention provides a method of differential display of prokaryotic messages RNA by RTPCR, the method comprising the steps of: adding a first primer mixture to a first nucleic acid sample including a first mixture of mRNA to form a first primer/first nucl...
07/06/2004
6759241Adjuvant comprising a lipopolysaccharide antagonist
LPS preparations, isolated from gram negative bacterial strains that contain at least one mutation in at least one of the htrB and msbB genes, and methods and therapeutics related thereto. The LPS preparations display both LPS antagonist and adjuvant activities....
07/06/2004
6699656Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
The present invention relates to ଲ-hCG, particularly ଲ-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention...
03/02/2004
6699834Method for treating cancer
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin ଲ-chain as well as methods for treatment of cancer, using human chorionic gonadotropin, employing the ଲ-chain of human chorionic gonadotropin...
03/02/2004
6660904HIV and CD4 transgenic animals and uses therefor
The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further included are methods for identifying therapeutic compounds...
12/09/2003
6620985PAD4 nucleic acid compositions from Arabidopsis and methods therefor
PAD4 compositions from Arabidopsis, including genomic and cDNA nucleic acid sequences, and methods for using said compositions in plants are provided. PAD4 from Arabidopsis is demonstrated to be regulatory and is required upstream from salicylic acid in t...
09/16/2003
6620416Method for treating HIV
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin ଲ-chain as well as methods for treatment and prevention of diseases, including HIV infection, using human chorionic gonadotropin, employing the &#x...
09/16/2003
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