Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7459161 | Methods for eliciting an immune response using cytolysin and hemolysin fusion proteins The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export machinery endogenous to the host bacterium into which the protein expor... | 12/02/2008 |
| 7400397 | Optical structures for metal-enhanced sensing The present invention is directed to optical structures and methods detecting the fluorescence of a molecule using metal-enhanced fluorescence. In particular, the invention describes the use of surface plasmon excitation for excitation of fluorophores near the metal... | 07/15/2008 |
| 7399474 | Isolation and characterization of the operon (ETEC-CS4 pili) and methods of using same Compositions comprising products of the csa operon, an isolated nucleic acid encoding the csa operon or functional fragments thereof, purified polypeptide products of the csa operon or functional fragments thereof, methods of eliciting an immune response to these pr... | 07/15/2008 |
| 7393525 | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same A method for introducing and expressing genes in animal cells is disclosed comprising infecting said the animal cells with live invasive bacteria, wherein bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a vaccine anti... | 07/01/2008 |
| 7387614 | Drug delivery to the inner ear and methods of using same The inventors have demonstrated that they can deliver therapeutic compositions to the inner ear of mammals via a variety of routes including the round window membrane, the semicircular canals, via cochleostomy and through the stapes footplate. Using pancaspase inhib... | 06/17/2008 |
| 7333591 | Method for the planning and delivery of radiation therapy A new optimization method for generating treatment plans for radiation oncology is described and claimed. This new method works for intensity modulated radiation therapy (IMRT), intensity modulated arc therapy (IMAT), and hybrid IMRT. ... | 02/19/2008 |
| 7312197 | Method of modifying glucose activity using polypeptides selectively expressed in fat tissue Isolated omentin polypeptides that selectively express in omental fat tissue and methods for the use of the polypeptides. The polypeptides can be used in a method for modifying insulin action and/or glucose metabolism in an animal. The polypeptides can be used to pr... | 12/25/2007 |
| 7294689 | Agonist polypeptide of receptor for Zot and Zonulin Agonist polypeptide of a receptor protein has been identified. The agonist can be used to facilitate drug and antigen absorption. Suitable routes of administration include oral, nasal, transdermal, and intravenous. Pharmaceutical formulations may comprise a therapeu... | 11/13/2007 |
| 7291334 | Antibodies to novel proteins in enteroaggregative (EAEC) useful for diagnosis and therapy of EAEC infections Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, an... | 11/06/2007 |
| 7285574 | Methods for treating neural cell swelling A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nuc... | 10/23/2007 |
| 7276240 | Antibodies to novel proteins in enteroaggregative (EAEC) useful for diagnosis and therapy of EAEC infections Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, an... | 10/02/2007 |
| 7273963 | Malarial animal model having a chimeric human liver The present invention features a non-human animal model of malaria, e.g., Plasmodium, particularly Plasmodium falciparum. The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene pr... | 09/25/2007 |
| 7265143 | C-4 substituted retinoids C-4 substituted retinoic acid analogs, synthesis methods of C-4 substituted retinoic acid analogs and methods of using C-4 substituted retinoic acid analogs to treat various cancers and dermatological diseases and conditions. The C-4 substituted retinoic acid analog... | 09/04/2007 |
| 7211559 | Factor VIII compositions and methods The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids ... | 05/01/2007 |
| 7192702 | Modulators of the interaction between Arp2/3 and cortactin or HS-1 The invention relates to methods for screening compounds for their ability to modulate actin polymerization. The invention is also related to compounds which modulate actin polymerization. More specifically, the invention is related to methods of screening compounds... | 03/20/2007 |
| 7189696 | Peptide antagonists of zonulin and methods for use of the same Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. ... | 03/13/2007 |
| 7041986 | Device for discrimination of fluorescence lifetimes and uses therefor The present invention provides methods for determining fluorescence lifetime of a fluorophor or an optical sensor using frequency domain gated detection. The method comprises the steps of exciting the fluorophor with frequency modulated light from a pulsed light sou... | 05/09/2006 |
| 7038078 | Methods of synthesizing and using derivatives of [2-(2-aminoethoxy)ethoxy] acetic acid A synthetic reaction to produce [2-(2-aminoethoxy)ethoxy] acetic acid (AEEA) derivatives. This synthetic reaction does not require isolation and purification of intermediates. The AEEA derivatives can be used to synthesize high load polystyrene-polyethylene glycol-l... | 05/02/2006 |
| 7016606 | Error mitigation system using line coding for optical WDM communications An apparatus and method of line coding to mitigate collision induced errors in Wavelength Division Multiplexing (WDM) optical communications systems is disclosed. The apparatus and method prevents Soliton-Soliton-Collision induced errors by reducing a variance in a ... | 03/21/2006 |
| 6718087 | System and method for reducing differential mode dispersion effects in multimode optical fiber transmissions A system and method for compensating for unwanted modes in multimode fiber transmissions includes a detector that receives an optical signal transmitted through a multimode optical fiber and converts the transmitted optical signal to a detector signal, an adaptive e... | 04/06/2004 |
| 6657780 | Widely tunable and integrated optical system and method The present invention provides tunable optical system, and a method for forming the same, that exhibits a broader tuning range with fewer components than prior art tunable optical systems. The tunable optical system of the present invention includes a plu... | 12/02/2003 |
| 6542650 | Polarization-mode dispersion emulator Techniques and devices for emulating polarization-mode dispersion in an optical signal that transmits through an optical fiber by using multiple birefringent wave-guiding sections that are interconnected to have adjustable polarization-changing connectors... | 04/01/2003 |
| 6502442 | Method and apparatus for abrasive for abrasive fluid jet peening surface treatment An abrasive water treatment method and apparatus includes supporting a metal workpiece on a workpiece support and arranging a nozzle above a target surface of the workpiece so that the nozzle is pointed towards the target surface of the workpiece. A press... | 01/07/2003 |
| 6455249 | Method of amplifying DNA and RNA mismatch cleavage products Detection of probe fragment products of basepair mismatch cleavage indicate the presence and sequence of target DNA. Detection of the target is enhanced by amplification through recycling targets by maintaining an assay temperature between the melting poi... | 09/24/2002 |
| 6444683 | 17-azolyl steroids useful as androgen synthesis inhibitors Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed.... | 09/03/2002 |
| 6426505 | Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier A low cost apparatus and method for measuring nanosecond luminescence lifetimes with a modulated LED light source that is driven by a lock-in amplifier. The lock-in amplifier provides both a DC bias and an AC signal used to modulate the intensity of an LE... | 07/30/2002 |
| 6407841 | Reduction of collision induced timing jitter by periodic dispersion management in soliton WDM transmission Collisions between solitons in different frequency channels are one of the major sources of errors in transmission systems that utilize wavelength division multiplexing (WDM). Moreover, because standard transmission lines have lumped amplification, the fo... | 06/18/2002 |
| 6345940 | Cutting tools for drilling concrete, aggregate, masonry or the like materials A cutting tool (200, 202) has a longitudinally extending shaft portion (208) with a chucking part (204) and a cutting head (206). A cutting edge (220) is formed on the cutting head (206). The cutting edge (220) includes at least one cutting portion. A rak... | 02/12/2002 |
| 6243181 | Reduction of collision induced timing jitter by periodic dispersion management in soliton WDM transmission Collisions between solitons in different frequency channels are one of the major sources of errors in transmission systems that utilize wavelength division multiplexing (WDM). Moreover, because standard transmission lines have lumped amplification, the fo... | 06/05/2001 |
| 6209481 | Sequential ion implantation and deposition (SIID) system A system for coating a surface of a substrate with a material includes a vacuum chamber and a vacuum pump configured to maintain a vacuum in the vacuum chamber. One or more ion source(s) are configured to implant ions of the material into the surface of a... | 04/03/2001 |
| 6207168 | Vaccine composition for herpes simplex virus and methods of using The present invention discloses a new vaccine composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.... | 03/27/2001 |
| 6174111 | Cutting tools for drilling concrete, aggregate, masonry or the like materials A cutting tool (200, 202) has a longitudinally extending shaft portion (208) with a chucking part (204) and a cutting head (206). A cutting edge (220) is formed on the cutting head (206). The cutting edge (220) includes at least one cutting portion. A rak... | 01/16/2001 |
| 6160202 | Modification of seed crops with transcription factors The present invention relates to an isolated transcription factor gene which is expressed in a maturing dicot seed and which encodes a transcription factor protein which targets a promoter of a gene encoding seed storage proteins. One group of such genes ... | 12/12/2000 |
| 6156522 | Heparin binding--epidermal growth factor-like growth factor in the diagnosis of Interstitial Cystitis Interstitial cystitis (IC) is a chronic bladder disease for which the exact etiology is unknown and for which there is no reliably effective treatment. However, it is known that the bladder epithelium is often abnormal in IC. We discovered that normal, ad... | 12/05/2000 |
| 6150170 | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same A method for introducing and expressing genes in animal cells is disclosed comprising infecting said animal cells with live invasive bacteria, wherein said bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a ... | 11/21/2000 |
| 6136572 | Recombinant KAT enzyme and process for its preparation Disclosed are isolated DNAs encoding a kynurenine aminotransferase selected from the group consisting of: (a) isolated DNA sequences which encode rat KAT; (b) an isolated DNA sequence which hybridizes to isolated DNA sequences of (a) above and which encodes a ... | 10/24/2000 |
| 6133280 | Androgen synthesis inhibitors This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of synthesizing these novel compounds, pharmaceutical compos... | 10/17/2000 |
| 6054131 | Vaccine composition for herpes simplex virus and method of using The present invention discloses a new immunogenic composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.... | 04/25/2000 |
| 6055078 | Real time wavelength monitoring circuit A real time multi-channel wavelength monitoring circuit for monitoring Waveguide Division Multiplexing communications networks (WDM) is disclosed. The monitoring circuit monitors the full wavelength of an input signal by providing center offset inputs int... | 04/25/2000 |
| 6037118 | Viral characterization by direct detection of capsid proteins The present invention provides a method of direct detecting of capsid proteins from intact viral particles using matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry, which enables viral proteins to be characterized at the ... | 03/14/2000 |
