Assignee: University of Maryland

Location: Baltimore, MD
No. of patents: 43

Number	Title	Issue Date
8147828	Methods and compositions for modulation of blood-neural barrier Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular...	04/03/2012
8042209	Techniques for compensating movement of a treatment target in a patient Techniques for improving treatment delivered to a target site in a patient include delivering a treatment from a treatment delivery device to a target site in a patient supported by a patient support structure. During the delivery of treatment, a state of the patien...	10/25/2011
8026224	Tumor cells with increased immunogenicity and uses therfor Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic a...	09/27/2011
7875599	C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-c...	01/25/2011
7803917	Breast cancer resistance protein (BCRP) and antibodies thereto The present invention provides a breast cancer resistance polynucleotide and protein of Macaca mulata (rhesus monkey) and uses thereof. The present invention also provides anti-BCRP antibodies and uses thereof, particularly as a hematopoietic stem cell marker...	09/28/2010
7465788	Breast cancer resistance protein (BCRP) and antibodies thereto The present invention provides a breast cancer resistance polynucleotide and protein of Macaca mulata (rhesus monkey) and uses thereof. The present invention also provides anti-BCRP antibodies and uses thereof, particularly as a hematopoietic stem cell marker...	12/16/2008
7361730	Surface localized colligin/Hsp47 in carcinoma cells This invention relates, e.g., to colligin/Hsp47 molecules which are expressed on the surface of carcinoma cells and to the use of such expressed molecules as targets for, e.g., therapeutic agents or imaging agents. The invention also relates to peptides which bind s...	04/22/2008
7348135	Assay for detecting changes in mitochondrial membrane permeability and method of using same An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial compounds. In some embodiments, the intra-mitochondrial compounds may be...	03/25/2008
7237986	High speed metal drill bit A metal cutting drill bit has a shank portion, a flute portion defining a helix angle and a tip. The tip has a primary cutting edge extending to an outer periphery of the drill bit. The primary cutting edge has a rake face defining a rake angle. The rake angle is di...	07/03/2007
7090850	Proteins in enteroaggregative (EAEC) useful for diagnosis and therapy of EAEC infections Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, an...	08/15/2006
7091238	Thienylhydrazon with digitalis-like properties (positive inotropic effects) The invention discloses a compound having the formula (I) wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, unsubstituted phenyl, and substituted phenyl; R2 is selected from the group consisting of H, a...	08/15/2006
7087230	Proteins in enteroaggregative (EAEC) useful for diagnosis and therapy of EAEC infections Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, an...	08/08/2006
7056700	Use of ClyA hemolysin for excretion of proteins The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export machinery endogenous to the host bacterium into which the protein expor...	06/06/2006
7026294	Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes A method for prevention of delaying the onset of diabetes using peptide antagonists of zonulin, is disclosed. ...	04/11/2006
6991698	Magnetostrictive film actuators using selective orientation A method of making beams, clamps and other structures by curing a polymer containing a magnetostrictive material. A magnetostrictive material like TERFENOL-D™ is placed in a polymer. This mixture is put onto a slide in a film. The mixture is cured by UV light (or ...	01/31/2006
6977176	Plasmid maintenance system for antigen delivery The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression pla...	12/20/2005
6946248	Compositions and methods for microbial dechlorination of polychlorinated biphenyl compounds Bioremediative microorganisms comprising a 16S ribosomal subunit nucleic acid sequence and useful in various methods for dechlorinating chlorinated biphenyls (PCBs), including anaerobic dechlorination of ortho- and double-flanked chloro substituents of PCBs. The met...	09/20/2005
6878951	Helical electron beam generating device and method of use A device for generating helical electron beams that can be used for radiation therapy is disclosed. The device contains a tertiary collimating cone that can be attached to a gantry of a linear accelerator or placed directly below the gantry. The tertiary collimating...	04/12/2005
6807372	Integrated spectral encoder/decoder for optical CDMA communication system The encoder/decoder design for spectrum-encoded optical CDMA systems uses waveguide circuits monolithically integrated on one chip to fulfill essential encoding and decoding functions. The integrated device functions as a 1×2 wavelength selective Mach-Zehnder inter...	10/19/2004
6699207	Method and apparatus for detecting lameness in animals A computer-based diagnostic system is provided to detect and analyze ground reaction forces produced by an animal passing through the diagnostic system, and includes, in one aspect, a first plate and a second plate disposed adjacent the first plate, a fir...	03/02/2004
6682744	Pro-gut maturation and anti-inflammatory effects of lactobacillus and lactobacillus secreted proteins, carbohydrates and lipids Strains of Lactobacilli having the ability to reduce or block pro-inflammatory cytokines and also to induce anti-inflammatory cytokines are disclosed. These strains may be used to prepare therapeutic agents that reduce inflammation. Lactobacillus secreted...	01/27/2004
6653135	Dynamic protein signature assay An assay to determine the specific expression and suppression of proteins in response to a stressor is disclosed. An organism exposed to a stressor, including disease caused by exposure to, e.g., a parasite, or a substance suspected of causing an adverse ...	11/25/2003
6492120	Nucleic acid hybridization assay utilizing tricyclic target and signal amplification This invention relates generally to nucleic acid-based diagnostic assays for detecting, identifying and/or quantitating target sequences in a sample. More specifically, the invention utilizes sequential cleavage of nucleic acids to achieve target and sign...	12/10/2002
6479466	Compositions for treating viral infections, and methods therefor Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a subject in need thereof. Such compositions are particularly ef...	11/12/2002
6413768	Expression plasmids The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of exp...	07/02/2002
6340591	Integrative protein-DNA cochleate formulations and methods for transforming cells An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates...	01/22/2002
6284544	Determination of metal ions in solution by photoluminescence anisotropy Homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution, based the metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule, or the binding of a metal ion to a fluorescent labeled...	09/04/2001
6245320	Inhibition of mucin release from airway goblet cells by polycationic peptides Polycationic peptides have been shown to be effective inhibitors of mucin secretion. Inhibition of mucin secretion using these polycationic peptides may be an important tool in the treatment of diseases associated with mucin hypersecretion, including asth...	06/12/2001
6080726	Anti-viral and immuno stimulator polynucleotide duplex and use thereof A method of treating HSV-2 infection which comprises administering to a host subject to said infection an effective amount of a polynucleotide of the formula polyrI.polyr(C12 U) where n is an integer from 4 to 29. The polynucleotide is advantag...	06/27/2000
5994334	Androgen synthesis inhibitors This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. Novel compounds according to the present invention are steroid derivatives. These compounds are preferab...	11/30/1999
5962645	Antiproliferative factor from patients with interstitial cystitis A novel antiproliferative factor (APF) present in urine of patients with interstitial cystitis (IC) is described. This urine antiproliferative factor can serve as a marker for disease activity and its antagonists as therapeutic medicaments for IC. In addi...	10/05/1999
5928667	Drug delivery device and method for employing the same A drug delivery device comprising a single phase matrix of a rigid polymer and a flexible polymer, useful for sustained release of a pharmaceutically active ingredient, as well as a method for employing the same, are disclosed....	07/27/1999
5735942	Compositions containing bioactive glass and their use in treating tooth hypersensitivity A novel silica based bioactive glass composition that can be used in conjunction with a delivery agent such as a toothpaste, gel saliva, etc. having a particle size range	04/07/1998
5708030	Substituted kynurenines and process for their preparation The present invention relates to the use in the treatment of cognitive disorders associated with the aging processes of the brain and perinatal brain disorders of compounds which act as inhibitors of the enzyme kynurenine aminotransferase (KAT)....	01/13/1998
5599959	Analogues of acetylsalicylic acid and novel uses thereof The present invention provides a salicylate analogue having the structure ##STR1## wherein R is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl; pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, ...	02/04/1997
5196709	Fluorometry method and apparatus using a semiconductor laser diode as a light source A method and apparatus for detecting the change in phase angle and/or modulation of emitted fluorescence of a fluorophore excited by modulated light from a laser diode. The light is both monochromatic and coherent, and can contain harmonic frequency compo...	03/23/1993
5162206	Plasmids for foreign gene expression in B. subtilis A double-stranded DNA plasmid which includes a promoter DNA sequence that is not derived from a B. subtilis plasmid and a DNA sequence derived from a B. subtilis plasmid is useful for introducing into B. subtilis foreign DNA having a nucleic acid sequence...	11/10/1992
5135862	Method of isolating restriction fragment deletions in vibrio cholerae, products thereof This invention relates to a method of isolating deletion mutants of Vibrio cholerae, wherein the deletion is predetermined by digestion with restriction endonucleases of known specificity. The deletions are inserted into the Vibrio cholerae chromosome by ...	08/04/1992
4974162	Advanced signal processing methodology for the detection, localization and quantification of acute myocardial ischemia Monopolar ECG signals are converted into the multichannel spectrum and autocorrelation domains, and different decision variables are identified from the autospectra. Statically validated threshold levels are used for comparison with the decision variables...	11/27/1990
4961428	Non-invasive method and apparatus for describing the electrical activity of the surface of an interior organ A method and apparatus for processing a plurality of signals provided by an array of electrodes disposed on the surface of the body further comprising a reconstruction of the electrical activity on the surface of a selected interior organ according to the...	10/09/1990

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Assignee: University of Maryland