Assignee: University of Louisville Research Foundation, Inc.

Location: Louisville, KY
No. of patents: 55

Number	Title	Issue Date
8178045	Interchangeable preconcentrator connector assembly An interchangeable preconcentrator assembly comprises an outer housing and an inner housing defining a chamber. A biased urging member is held at least partially within the outer housing and slidably biased toward a surface of the inner housing. When the biased urgi...	05/15/2012
8168438	Chemical sensors for detecting hydrogen and methods of use The presently-disclosed subject matter provides sensors and methods for detecting hydrogen by determining the conductivity of a chemiresistant film upon exposure to hydrogen, including for example chemiresistant films comprised of alkylamine-, alkylthiolate-, and/or...	05/01/2012
8161916	Decubitus ulcer prevention garment for dogs Decubitus ulcer prevention garments for a dog are provided that include a fluid-filled bladder. The garments can include an inner layer that contacts and interacts with the body of the dog; an intermediate layer that interfaces with the inner layer and includes the ...	04/24/2012
8142806	Methods and compositions for controlled delivery of phytochemical agents The presently-disclosed subject matter provides compositions and methods for treating a cancer by providing a composition comprising a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, o...	03/27/2012
8132611	Metallic nanostructures self-assembly, and testing methods The invention provides method for metallic nanonstructures self-assembly methods and materials testing. Preferred embodiment methods permit for the formation of individual nanostructures and arrays of nanostructures. The nanostructures formed can have a metal alloy ...	03/13/2012
8088341	Analyte collection devices and methods An aspect of the invention is directed to an analyte collection device of the type that includes at least one plate for storing the analyte and a heating element for heating the at least one plate. An example device comprises a controller linked to the heating eleme...	01/03/2012
8076096	Alteration of cell membrane with FasL Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene therapy, without the introduction of exogenous DNA. DNA sequences, the...	12/13/2011
8073226	Automatic detection and monitoring of nodules and shaped targets in image data A method for detecting a nodule in image data including the steps of segmenting scanning information from an image slice to isolate lung tissue from other structures, resulting in segmented image data; extracting anatomic structures, including any potential nodules,...	12/06/2011
8067160	Genetic markers of schizophrenia The invention includes method of determining if a subject has a genetic predisposition to clinically diagnosed schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD). ...	11/29/2011
8039227	Peptide biomarkers predictive of renal function decline and kidney disease Methods for diagnosing a kidney disease, or the risk thereof, in a subject are provided. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least on...	10/18/2011
8029784	Method for the diagnosis and prognosis of malignant diseases Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin. ...	10/04/2011
8017582	Immunostimulatory compositions and methods The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune...	09/13/2011
8014561	Virtual fly over of complex tubular anatomical structures An embodiment of the invention is method, which can be implemented in software, firmware, hardware, etc., for virtual fly over inspection of complex anatomical tubular structures. In a preferred embodiment, the method is implemented in software, and the software rec...	09/06/2011
7988839	Capillary electrophoresis systems and methods An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality ...	08/02/2011
7964557	Inhibition of wet type age related macular degeneration (AMD) by adiponectin or acrp 30 The present invention provides new methods of treating wet type of age related macular degeneration by administering adiponectin (APN) or a functional fragment derived therefrom. One of the pathological complications of age related macular degeneration (AMD) is chor...	06/21/2011
7948421	Frequency counter based analog-to-digital converter An analog-to-digital converter (ADC) is provided. The ADC includes a variable oscillator, a frequency divider, a clock circuit, and a counter. The variable oscillator is coupled to a sensor and configured to generate an oscillating signal based on a measurement gene...	05/24/2011
7927602	Fas ligand-avidin/streptavidin fusion proteins This invention provides chimeric proteins comprising an apoptosis-inducing molecule fused to a member of a binding pair that is capable of binding to a selected cell that expresses a death receptor. When the selected cell is exposed in vivo or ex vivo to the chimeri...	04/19/2011
7892735	Genetic markers of schizophrenia spectrum disorders in the sulfotransferase 4a (sult4a) gene The invention includes method of determining if a subject is at risk for developing schizophrenia (SZ), schizotypal personality disorder (SPD), or schizoaffective disorder (SD). ...	02/22/2011
7887888	Methods and systems for fabrication of graphene nanoribbons A method for fabricating graphene nanoribbons comprises the steps of providing a chamber with a first and a second cavity, which are separated by a divider that defines an opening to place the first cavity in fluid communication with the second cavity; positioning a...	02/15/2011
7886959	Security monitoring system for a bulk foodstuff transport container A security monitoring system provides for the secure transport of a bulk foodstuff container. The system includes an electromechanical locking mechanism allowing access by only authorized persons, a positional locator for determining the geographical position of the...	02/15/2011
7883900	Enhancement of sensitivity of fluorophore mediated biosensing and bioimaging A method of enhancing fluorescence emission in a fluorophore-mediated sensing, biosensing, imaging, and bioimaging. An example of biosensing is a fluorophore-mediated sandwich immunoassay with a 1° monoclonal antibody against a target analyte and a fluorophore-link...	02/08/2011
7871573	Enhancement of sensitivity of fluorophore mediated biosensing and bioimaging A method of enhancing fluorescence emission in a fluorophore-mediated sensing, biosensing, imaging, and bioimaging. An example of biosensing is a fluorophore-mediated sandwich immunoassay with a 1° monoclonal antibody against a target analyte and a fluorophore-link...	01/18/2011
7838292	Methods for obtaining adult human olfactory progenitor cells An isolated human olfactory stem cell can be prepared by culturing human tissue from olfactory neuroepithelium to form neurospheres. ...	11/23/2010
7819974	Growth of textured gallium nitride thin films and nanowires on polycrystalline substrates A synthesis route to grow textured thin film of gallium nitride on amorphous quartz substrates and on single crystalline substrates such as c-sapphire and polycrystalline substrates such as pyrolytic boron nitride (PBN), alumina and quartz using the dissolution of a...	10/26/2010
7790242	Method for electrostatic deposition of graphene on a substrate A method for electrostatic deposition of graphene on a substrate comprises the steps of securing a graphite sample to a first electrode; electrically connecting the first electrode to a positive terminal of a power source; electrically connecting a second electrode ...	09/07/2010
7745215	Methods and compositions for expanding T regulatory cells The present invention provides methods and compositions for expanding Treg cells ex vivo or in vivo using one or more conjugates comprising a costimulatory moiety that stimulates at least one of three signals involved in Treg cell development and/or using dendritic ...	06/29/2010
7713352	Synthesis of fibers of inorganic materials using low-melting metals A process is provided to produce bulk quantities of nanowires in a variety of semiconductor materials. Thin films and droplets of low-melting metals such as gallium, indium, bismuth, and aluminum are used to dissolve and to produce nanowires. The dissolution of solu...	05/11/2010
7638481	Treatment of spinal cord injury The present invention relates to the treatment of spinal cord injury with a vaccinia virus complement control protein (VCP). ...	12/29/2009
7598345	Immunostimulatory compositions and methods The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune...	10/06/2009
7597941	Tubular carbon nano/micro structures and method of making same A method of synthesizing and controlling the internal diameters, conical angles, and morphology of tubular carbon nano/micro structures. Different morphologies can be synthesized included but not limited to cones, straight tubes, nozzles, cone-on-tube (funnels), tub...	10/06/2009
7591897	Method for the rapid synthesis of large quantities of metal oxide nanowires at low temperatures A process for the rapid synthesis of metal oxide nanoparticles at low temperatures and methods which facilitate the fabrication of long metal oxide nanowires. The method is based on treatment of metals with oxygen plasma. Using oxygen plasma at low temperatures allo...	09/22/2009
7572217	System and method for providing cardiac support and promoting myocardial recovery A system for providing cardiac support to a patient and for promoting myocardial repair and recovery, comprises a device for connecting to a vasculature of the patient and a control module. The device includes a pump, defining a blood-receiving volume, and a cannula...	08/11/2009
7432301	Use of S-nitrosothiol signaling to treat disordered control of breathing The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disorde...	10/07/2008
7429376	Methods of screening for compounds that improve engraftment The invention provides for methods of screening for compounds that increase the expression of P-selectin, SDF-1, and/or CXCR4 on facilitatory cells (FCs). The invention also provides for methods of screening for compounds that increase the level of p-predendritic ce...	09/30/2008
7399789	Bone targeting compounds for delivering agents to bone for interaction therewith The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or ...	07/15/2008
7357928	Method for the diagnosis and prognosis of malignant diseases Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin. ...	04/15/2008
7196220	Bone targeting compounds for delivering agents to the bone for interaction therewith The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the b...	03/27/2007
7157227	Microarrays to screen regulatory genes Microarray technology allows the multiple parallel processing of information generated from matrices of huge numbers of loci on a solid substrate, which is useful in the gathering of gene signatures defining specific biological states. An approach has been developed...	01/02/2007
7139602	Shape analysis of surfaces A method and apparatus are provided to map the shape or thickness of a surface. Thickness estimates across a distance are received, and Fourier analysis is performed to generate Fourier amplitude coefficients and phase values for a number of frequency components. Li...	11/21/2006
7084106	Application of a viral complement inhibitory protein in the treatment and diagnosis of Alzheimer's Disease The present invention provides a novel treatment for senile dementia (Alzheimer's Type), comprising administering an anti-complement protein to a patient in need of such treatment in an amount sufficient to inhibit the complement cascade and thereby inhibit the prod...	08/01/2006

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Assignee: University of Louisville Research Foundation, Inc.