Assignee: University of Iowa Research Foundation

Location: Iowa City, IA
No. of patents: 196

Number	Title	Issue Date
8158592	Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop...	04/17/2012
8155403	Methods and devices for airway tree labeling and/or matching Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly us...	04/10/2012
8148340	Immunomodulatory oligonucleotides Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are...	04/03/2012
8137682	Isolated complexes of covalently cross-linked endotoxin and modified MD-2 Applicants have produced and isolated chemically cross-linked complexes of endotoxin and modified MD-2, and have developed methods of using these complexes. ...	03/20/2012
8124518	Semiconductor heterostructure nanowire devices Nanowire devices comprising core-shell or segmented nanowires are provided. In these nanowire devices, strain can be used as a tool to form metallic portions in nanowires made from compound semiconductor materials, and/or to create nanowires in which embedded quantu...	02/28/2012
8119766	Increasing functional glycosylation of alpha-dystroglycan in the treatment of muscle degeneration Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to increase functional glycosylation of α-dystroglycan in an affected tissue...	02/21/2012
8114848	Immunomodulatory oligonucleotides Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are...	02/14/2012
8090431	Systems and methods for bioluminescent computed tomographic reconstruction An image of an object is synergistically reconstructed using two or multiple imaging modalities. A first reconstructed image, showing structural information of the object is produced using a first imaging modality. The first reconstructed image is segmented, and kno...	01/03/2012
8088579	Complement factor H for diagnosis of age-related macular degeneration The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD. ...	01/03/2012
8088396	Isolated complexes of endotoxin and modified MD-2 Applicants have produced and isolated water soluble complexes of endotoxin and modified MD-2. ...	01/03/2012
8077152	Magneto resistive elements and methods for manufacture and use of same The instant disclosure provides and describes a magneto resistive element comprised of a first electrode; a second electrode; and a semi conductive/conductive organic layer disposed between the first and second electrodes, wherein the magneto resistive element has a...	12/13/2011
8058249	Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop...	11/15/2011
8012683	Variants in complement regulatory genes predict age-related macular degeneration Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including p...	09/06/2011
8012466	Immunogenic compositions for activating γδ T cells Disclosed are compositions, kits, and methods for activating, expanding, or stimulating γδ T cells that include recombinant attenuated microbes. The compositions may include pharmaceutical compositions that are used as γδ T cell stimulating immunogenic compositi...	09/06/2011
8000798	Cochlear implant system substantially preserving the hydrodynamic nature of the cochlea An electrode array (30) which is able to be inserted to a desired depth within the cochlea to provide useful percepts for the recipient which will also preferably not cause damage to the sensitive structures of the cochlea. The electrode array (30) is ...	08/16/2011
7992422	Breath-based sensors for non-invasive molecular detection A method of diagnosing the health of an individual by collecting a breath sample from the individual and measuring the amount of each of a plurality of analytes in the sample. The amount of each analytes is measured by fitting a time response curve of a sample-evalu...	08/09/2011
7989675	Method of identifying compounds using a transgenic pig model of cystic fibrosis The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions. ...	08/02/2011
7963996	Ankle prosthesis methods Methods of implanting an ankle prosthesis in a subject having an ankle joint in need of replacement. ...	06/21/2011
7960715	Semiconductor heterostructure nanowire devices Nanowire devices comprising core-shell or segmented nanowires are provided. In these nanowire devices, strain can be used as a tool to form metallic portions in nanowires made from compound semiconductor materials, and/or to create nanowires in which embedded quantu...	06/14/2011
7951979	2,4,6-trisubstituted phenols having anesthetic properties Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed. ...	05/31/2011
7951880	Compositions for breast implant filling and methods of use The methods and compositions disclosed herein describes a solution containing at least one block co-polymer that is a liquid at lower temperatures and transitions to a gel at higher temperatures. The compositions are useful, for example, as an alternative to saline ...	05/31/2011
7951781	Methods and compositions related to PLUNC surfactant polypeptides Embodiments include compositions and methods for lower the surface tension of a liquid-air interface by contacting such interface with all or part of a PLUNC polypeptide. ...	05/31/2011
7951531	Flavivirus NS5A proteins for the treatment of HIV GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving a-GBV-C NS5A peptide or polypeptide for inhibiting and treating HIV infections. ...	05/31/2011
7935675	Immunostimulatory nucleic acid molecules Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful ...	05/03/2011
7931893	Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelo...	04/26/2011
7902228	Schweinfurthin analogues Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods c...	03/08/2011
D633820	Vase	03/08/2011
D632997	Vase	02/22/2011
D632996	Vase	02/22/2011
7888327	Methods of using immunostimulatory nucleic acid molecules to treat allergic conditions Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop...	02/15/2011
7879812	Immunomodulatory oligonucleotides and methods of use therefor The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR)9. Particular 4-5 base extensions at the 5′ and of the previously described core inhibitory ODN sequence enhances their inhibitory act...	02/01/2011
7879810	Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop...	02/01/2011
7867727	Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treati...	01/11/2011
7858062	Synthesis and use of nanocrystalline zeolites Embodiments of the present invention relate to a method for synthesizing nanocrystalline zeolites, the method comprising contacting starting products that comprise a solvent, a silicon source, a cation base, an organic template, and an aluminum source, or any combin...	12/28/2010
7842178	Magnet incorporated electrically conductive electrodes An electrically conducting electrode having a composite and a current collector in electrical contact with the composite, the composite can comprise at least about 10 weight percent electrically conductive particles, at least about 0.5 weight percent magnetic partic...	11/30/2010
7840249	Clinical micro-CT (CMCT) methods, techniques and apparatus The present invention relates to a method and system (CMCT system) for improving spatial resolution imaging of CT systems. The systems and method can achieve improved spatial resolution while using CT X-ray dosage levels comparable to those currently used in practic...	11/23/2010
7833537	Use of parasitic biological agents for prevention and control of autoimmune diseases The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to reduce the excessive immune response in an individual. This invention...	11/16/2010
7807355	Diagnostics and therapeutics for glaucoma Methods and compositions for diagnosing and treating glaucoma are disclosed. ...	10/05/2010
7803622	Adeno-associated virus vectors The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persiste...	09/28/2010
7795380	Compositions and methods for nucleic acid delivery Compositions and methods are described for non-viral nucleic acid delivery. A targeting peptide capable of mediating targeting to a cell or subcellular compartment is derivatized with a photoaffinity label. Following an ionic interaction with a polynucleotide, such ...	09/14/2010

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Assignee: University of Iowa Research Foundation