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| Number | Title | Issue Date |
| 8178629 | Conjugated polymer fiber, preparation and use thereof Described are conjugated polymer fibers and nanofibers, methods of making, and methods of use thereof. The conjugated polymer fibers and nanofibers can be prepared by an electrostatic spinning process followed by crosslinking. ... | 05/15/2012 |
| 8163953 | Compounds for lysosomal modulation and methods of use Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Aβ and other protein and glycoconjugate species are provided. Methods for the treatment of neurodegenerative diseases that inv... | 04/24/2012 |
| 8163520 | Nucleic acids encoding a chimeric polypeptide comprising IL-7 and HGF-beta chain and methods of use The present invention relates to a single-chain or chimeric polypeptide comprising a cytokine and a growth factor linked by at least one amino acid residue, and wherein the chimeric polypeptide enhances the proliferation and/or differentiation of hematopoietic precu... | 04/24/2012 |
| 8153116 | Use of conditional plasmodium strains lacking an essential gene in malaria vaccination The present invention relates to a malaria vaccine for administration to a host, comprising an attenuated malarial parasite with a gene that has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for... | 04/10/2012 |
| 8152848 | Structural/biological implant system A structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need to obtain autologous bone. The implant has an apical portion that is f... | 04/10/2012 |
| 8150033 | Optical security system using fourier plane encoding A method of encrypting a set of data is disclosed. The method may include encoding a set of data with a first encryption key, and transforming the set of data encoded with the first encryption key. The method may also include using a second encryption key to encode ... | 04/03/2012 |
| 8137103 | Implant system An implant system may comprise implants, abutments, cylinders and a structural framework with a veneer thereon. A prosthesis comprises the structural framework and veneer. The cylinders are provided with grooves or shelves thereon to retain a structural framework th... | 03/20/2012 |
| 8128921 | Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination The present invention relates to a malaria vaccine for administration to a host comprising an attenuated malarial parasite with a gene which has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for... | 03/06/2012 |
| 8124084 | Compositions and methods for immunomodulation in an organism using IL-15 and soluble IL-15Ra The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an eff... | 02/28/2012 |
| PP22465 | plant named ‘Summer Skies’ Buddleja davidii ‘Summer Skies’ is a distinct form of butterfly bush that combines several desirable characteristics in a landscape plant including the following: upright and outwardly spreading plant habit; green and yellow to bright white leaf variegati... | 01/24/2012 |
| 8097385 | Bipolar plate for fuel cell The present disclosure provides for a bipolar plate assembly for use in a fuel cell stack. The bipolar plate assembly includes: (a) at least one flow field layer defining a flow field portion and a perimeter portion; (b) at least one core assembly including at least... | 01/17/2012 |
| 8084467 | Pyrazole derivatives as cannabinoid receptor antagonists One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the i... | 12/27/2011 |
| 8084451 | Heteropyrrole analogs acting on cannabinoid receptors Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect discloses hetero pyrrole analogs acting as antagonists for the CB1 and... | 12/27/2011 |
| 8058515 | Plant cells and plants overexpressing vacuolar proton pyrophosphatases The present invention relates to a transgenic plant, comprising one or more plant cells transformed with exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and ... | 11/15/2011 |
| 8058226 | Albumin-free factor VIII formulations A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent select... | 11/15/2011 |
| 8029808 | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an α2M ... | 10/04/2011 |
| 8011864 | Method for facilitating chatter stability mapping in a simultaneous machining application Systems and methods are provided for use in assessing the stability of simultaneous machining (SM) dynamics (which is also known as parallel machining). In SM, multiple cutters, which are generally driven by multiple spindles at different speeds, operate on the same... | 09/06/2011 |
| 8003852 | Transgenic plants overexpressing a plant vacuolar pyrophosphatase Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower,... | 08/23/2011 |
| 7989534 | Polymer-clay nanocomposites and methods of making the same Polymer-clay nanocomposites and methods of making the same are provided. In an embodiment, a polymer-clay nanocomposite comprises a non-metal salt of an ionomer and a nanostructured layered clay. An example of the ionomer is a tetra-octyl ammonium salt of sulfonated... | 08/02/2011 |
| 7955596 | prevention and treatment: mutant lacking luxs activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthrac... | 06/07/2011 |
| 7906573 | Crosslinked polycyclooctene Chemically crosslinked polycyclooctene having excellent shape recovery properties is prepared by ring-opening metathesis polymerization of cis-cyclooctene followed by chemical crosslinking. The crosslinked polycyclooctene can be shaped, the shape memorized, a new sh... | 03/15/2011 |
| 7892492 | Flow-through apparatus for microscopic investigation of dissolution of pharmaceutical solids The present disclosure is directed to an apparatus and method for studying dissolution of a compact sample. The compact sample is typically a pharmaceutical drug sample. A flow-through apparatus includes a frame defining a flow-through channel, a removable insert ha... | 02/22/2011 |
| 7879093 | Electrospun apatite/polymer nano-composite scaffolds An artificial bone composite structure is provided. This structure includes a fibrous matrix that itself includes a plurality of fibers. Also, the structure includes a plurality of hydroxyapatite (HA) particles. These particles are dispersed within the fibrous matri... | 02/01/2011 |
| 7859944 | Apparatus, systems and methods for enhanced multi-carrier based underwater acoustic communications Advantageous OFDM-based underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. In general, OFDM transmissions over UWA channels encounter frequency-dependent Doppler drifts that destroy the orthogonality among OFDM... | 12/28/2010 |
| 7838562 | Methods of inhibiting vascular permeability and apoptosis Agonist of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial s... | 11/23/2010 |
| 7820144 | Receptor selective cannabimimetic aminoalkylindoles Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may include radioactive atoms. Also disclosed are methods of using the disc... | 10/26/2010 |
| 7782573 | Trellis-based feedback reduction for multiple input multiple output orthogonal frequency division multiplexing (MIMO-OFDM) with rate-limited feedback Trellis-based methods for reducing feedback while maintaining performance in a Multiple Input, Multiple Output Orthogonal Frequency Division Multiplexing (MIMO-OFDM) system. The methods involve: receiving a plurality of symbols from a plurality of sub-carriers at a ... | 08/24/2010 |
| 7776753 | Method of fabricating semiconductor devices employing at least one modulation doped quantum well structure and one or more etch stop layers for accurate contact formation A method of fabricating a semiconductor device includes the steps of forming (or providing) a series of layers formed on a substrate, the layers including a first plurality of layers including an n-type ohmic contact layer, a p-type modulation doped quantum well str... | 08/17/2010 |
| 7745440 | Pyrazole analogs acting on cannabinoid receptors One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the i... | 06/29/2010 |
| 7741548 | Method and composition for increasing branching and flowering response in plants A unique fusion gene is disclosed which is useful for transforming a wide range of plants, resulting in a significant alteration of the plant phenotype with respect to shoot and floral tissue response, but not affecting root growth or function. The gene construct in... | 06/22/2010 |
| 7741365 | Peripheral cannabinoid receptor (CB2) selective ligands Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites. ... | 06/22/2010 |
| 7723498 | Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use The present invention relates to novel monooxygenase nucleic acids and polypeptides created using mutagenesis, DNA shuffling, or both, in a single iteration or multiple iterations, and methods for their creation and use. The monooxygenase enzymes of the present disc... | 05/25/2010 |
| 7723300 | Regulators of the non-genomic action of progesterone and methods of use A progesterone regulator capable of modulating the non-genomic action of progesterone and methods of using the progesterone regulator are described. The progesterone regulator is useful for attenuating progesterone's inhibition of apoptosis and for the treatment of ... | 05/25/2010 |
| 7705098 | Crosslinked polycyclooctene Chemically crosslinked polycyclooctene having excellent shape recovery properties is prepared by ring-opening metathesis polymerization of cis-cyclooctene followed by chemical crosslinking. The crosslinked polycyclooctene can be shaped, the shape memorized, a new sh... | 04/27/2010 |
| 7695970 | Optical fiber based fluorescence sensor for in-situ measurement and control of fuel cells The present invention provides, a system and method for unobtrusively determining water content within a fuel cell. One embodiment of a system in accordance with the present invention includes a fuel cell body including an ionomeric membrane, water and a fluorophore... | 04/13/2010 |
| 7689086 | Resonant leaky-mode optical devices and associated methods Optical devices with versatile spectral attributes are provided that are implemented with one or more modulated and homogeneous layers to realize leaky-mode resonance operation and corresponding versatile spectral-band design. The first and/or higher multiple evanes... | 03/30/2010 |
| 7684098 | Optical security system using fourier plane encoding A system for encrypting a set of data may include a signal source, and a first, second, third, and fourth subsystem. The first subsystem may receive a first signal from the signal source and provide as output therefrom a first output signal. The second subsystem may... | 03/23/2010 |
| 7666867 | Heteroindanes: a new class of potent cannabimimetic ligands One aspect of the invention is concerned with cannabimimetic heteroindane analogs having affinities and/or selectivities for a cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and m... | 02/23/2010 |
| 7630076 | Dual-detector systems and methods having utility in biomolecular measurements Apparatus, systems and methods for measurement of B22 values of proteins in aqueous solutions in flow-mode utilize a dual-detector cell are provided. Simultaneous measurement of protein concentration and scattered light intensity is facilitated as the pro... | 12/08/2009 |
| 7625649 | Vapor feed fuel cells with a passive thermal-fluids management system The invention provides a fuel cell system, such as a direct methanol fuel cell (DMFC) that uses passive approaches to thermal-fluids management. In accordance with one embodiment of the invention, a fuel cell is provided that uses a passive fuel delivery system. In ... | 12/01/2009 |
