Assignee: University of Chicago

Location: Chicago, IL
No. of patents: 136

Number	Title	Issue Date
8053627	Methods for treating demyelination disorders This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an ani...	11/08/2011
7989116	Electrolyte utilizing a lewis acid/bronstead acid complex A proton conducting polymer is described herein which generally comprises a proton donating polymer and a Lewis acid. The Lewis acids may comprise one or more rare earth triflates. The proton conducting polymer exhibits excellent proton conductivity in low humidity ...	08/02/2011
7901939	Method for performing crystallization and reactions in pressure-driven fluid plugs The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. ...	03/08/2011
7884260	Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an ani...	02/08/2011
7879476	Proton conducting electrolyte A cationic conductive polymer is described herein which generally comprises a proton donating polymer and an oxocarbonic acid. The cationic conductive polymer exhibits a high conductivity in low humidity environments. ...	02/01/2011
7754941	Animal models for demyelination disorders This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an ani...	07/13/2010
7714167	Catalytic asymmetric epoxidation The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst syste...	05/11/2010
7655470	Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale. ...	02/02/2010
7588940	Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps An apparatus and method for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials. The apparatus and method involves use of one or more diffractive optical elements which each receive a lase...	09/15/2009
7456013	Plant centromere compositions The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells....	11/25/2008
7444011	Imaging system performing substantially exact reconstruction and using non-traditional trajectories A method and apparatus for reconstruction of a region of interest (ROI) for an object using an imaging system is provided. The imaging system may substantially exactly reconstruct the ROI with a straight line trajectory. In the straight line trajectory, the ROI is n...	10/28/2008
7423194	Animal models for demyelination disorders This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an ani...	09/09/2008
7418123	Automated method and system for computerized image analysis for prognosis An automated method for determining prognosis based on an analysis of abnormality (lesion) features and parenchymal features obtained from medical image data of a patient. The techniques include segmentation of lesions from radiographic images, extraction of lesion ...	08/26/2008
7379572	Method for computer-aided detection of three-dimensional lesions A method, system, and computer program product for identifying at least one three-dimensionally extended lesion within a volumetric region encompassing an inner surface, an outer surface, and intervening tissue of a target organ. The method includes: (1) generating ...	05/27/2008
7354898	Identification of novel factors that block programmed cell death or apoptosis by targeting JNK Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway...	04/08/2008
7330255	Total internal reflection fluorescence apparatus Techniques are provided for illuminating a sample by using total internal reflection (TIR) from a diffraction limited focused annular illumination beam. The illumination forms an affected region and an overlapping confocal region that may have dimensions the below 1...	02/12/2008
7326418	Identification of novel factors that block programmed cell death or apoptosis by targeting JNK Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway...	02/05/2008
7305111	Automated method and system for the detection of lung nodules in low-dose CT images for lung-cancer screening A method, system, and computer program product for detecting at least one nodule in a medical image of a subject, including identifying, in the medical image, an anatomical region corresponding to at least a portion of an organ of interest; filtering the medical ima...	12/04/2007
7298883	Automated method and system for advanced non-parametric classification of medical images and lesions A computer-aided diagnosis (CAD) scheme to aid in the detection, characterization, diagnosis, and/or assessment of normal and diseased states (including lesions and/or images). The scheme employs lesion features for characterizing the lesion and includes non-paramet...	11/20/2007
7298881	Method, system, and computer software product for feature-based correlation of lesions from multiple images A method, system, and computer software product for correlating medical images, comprising: obtaining first image data representative of a first medical image including a first abnormality; obtaining second image data representative of a second medical image includi...	11/20/2007
7251353	Automated method of patient recognition using chest radiographs A method for determining whether a first medical image and a second medical image are medical images of the same patient, comprising selecting a first region in the first medical image; selecting a second region in the second medical image; determining a common regi...	07/31/2007
7236619	System and method for computer-aided detection and characterization of diffuse lung disease An automated computerized scheme for detection and characterization of diffuse lung diseases on high-resolution computed tomography (HRCT) images including obtaining image data including pixels of an organ; segmenting the image data into organ image data and non-org...	06/26/2007
7232989	Transverse optical accelerator and generalized optical vortices A method and system for generating modulated optical vortices. Optical vortices can be used for a variety of applications, such as applying controlled torque or controlled force patterns to objects from a few nanometers to hundreds of micrometers in size. Numerous o...	06/19/2007
7233423	Optical fractionation methods and apparatus Static arrays of optical traps can be used to sort microscopic objects with exponential sensitivity to size. Such optical fractionation relies on competition between an externally applied force and the moving objects' differing affinities for optical gradient traps....	06/19/2007
7193128	Methods for generating or increasing revenues from crops The present invention provides methods of doing business and providing services. For example, methods of increasing the revenue of crops are provided. To this end, the method includes the use of a nucleic acid sequences of plant centromeres. This will permit constru...	03/20/2007
7176445	Use of multiple optical vortices for pumping, mixing and sorting A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more opt...	02/13/2007
7137574	Apparatus and process for the lateral deflection and separation of flowing particles by a static array of optical tweezers A method and apparatus for laterally deflecting and/or separating a flow of particles using a static array of optical tweezers. In an array of optical tweezers with a lattice constant larger than the size of a particle of interest, particles driven past the array by...	11/21/2006
7129091	Device and method for pressure-driven plug transport and reaction The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. ...	10/31/2006
7123762	Method and system for risk-modulated diagnosis of disease A method of calculating a disease assessment by analyzing a medical image, comprising (1) extracting at least one lesion feature value from the medical image; (2) extracting at least one risk feature value from the medical image; and (3) determining the disease asse...	10/17/2006
7109473	Transverse optical accelerator and generalized optical vortices A method and system for generating modulated optical vortices. Optical vortices can be used for a variety of applications, such as applying controlled torque or controlled force patterns to objects from a few nanometers to hundreds of micrometers in size. Numerous o...	09/19/2006
7104659	Apparatus for using optical tweezers to manipulate materials A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control ...	09/12/2006
7083672	Method and product for phosphosilicate slurry for use in dentistry and related bone cements The present invention is directed to magnesium phosphate ceramics and their methods of manufacture. The composition of the invention is produced by combining a mixture of a substantially dry powder component with a liquid component. The substantially dry powder comp...	08/01/2006
7077983	Polymer nanocomposites for lithium battery applications A single ion-conducting nanocomposite of a substantially amorphous polyethylene ether and a negatively charged synthetic smectite clay useful as an electrolyte. Excess SiO2 improves conductivity and when combined with synthetic hectorite forms superior me...	07/18/2006
7075060	Optical peristaltic pumping with optical traps A method of use for holographic optical traps or gradients in which repetitive cycling of a small number of appropriately designed arrays of traps are used for general and very complex manipulations of particles and volumes of matter. Material transport results from...	07/11/2006
7070927	Methods and compositions for efficient nucleic acid sequencing Disclosed are novel methods and compositions for rapid and highly efficient nucleic acid sequencing based upon hybridization with two sets of small oligonucleotide probes of known sequences. Extremely large nucleic acid molecules, including chromosomes and non-ampli...	07/04/2006
7031845	Method for determining biological expression levels by linear programming A method for determining a matrix of expression levels corresponding to a set of biological targets (e.g., genes or gene fragments) and a set of biological samples, including obtaining a matrix of signal values corresponding to the set of biological targets; computi...	04/18/2006
7015372	Plant artificial chromosome compositions and methods The present invention provides for the identification and cloning of functional plant centromeres in Arabidopsis. This will permit construction of stably inherited plant artificial chromosomes (PLACs) which can serve as vectors for the construction of transge...	03/21/2006
6974070	Joining of advanced materials by superplastic deformation A method for utilizing superplastic deformation with or without a novel joint compound that leads to the joining of advanced ceramic materials, intermetallics, and cermets. A joint formed by this approach is as strong as or stronger than the materials joined. The me...	12/13/2005
6963253	Broadband high precision circular polarizers and retarders in waveguides A retarder is presented for application in systems that transmit radiation through waveguides, such as microwave or millimeter-wave systems. The retarder is a compound device comprising multiple single element retarders, each of which introduces a retardation phase ...	11/08/2005
6937776	Method, system, and computer program product for computer-aided detection of nodules with three dimensional shape enhancement filters A method, system, and computer program product for evaluating an image including an object, including filtering image data derived from the image with a first geometric enhancement filter having magnitude and likelihood filter components so as to produce first filte...	08/30/2005

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Assignee: University of Chicago