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| Number | Title | Issue Date |
| 5591610 | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods RNA enzymes or ribozymes can act as endoribonucleases, catalyzing the cleavage of RNA molecules with a sequence specificity of cleavage greater than that of known ribonucleases and approaching that of the DNA restriction endonucleases, thus serving as RNA... | 01/07/1997 |
| 5453496 | Polynucleotide phosphorodithioate Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.... | 09/26/1995 |
| 5313947 | CW and pulsed doppler diagnostic system A frequency to voltage converter including input terminals for receiving a stream of pulses with either fixed or variable time intervals between pulses, means for producing a voltage that varies as an inverse function of the time interval between the puls... | 05/24/1994 |
| 5278302 | Polynucleotide phosphorodithioates The present invention relates to novel oligonucleotides having phosphorodithioate internucleotide linkages which may be used for the treatment of diseases caused by viruses.... | 01/11/1994 |
| 5218103 | Nucleoside thiophosphoramidites The present invention relates to new and useful nucleside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorothioamidate phosphoramidite compounds as well as the process whereby these compounds can be used for synthe... | 06/08/1993 |
| 5153319 | Process for preparing polynucleotides New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucle... | 10/06/1992 |
| 5141552 | Method of hybridizing cotton Cotton plants may be rendered male sterile while retaining substantial female fertility by contracting the plants with a gametocidally effective amount of a novel compound which has the formula: ##STR1## where X is oxygen, sulfur, or ##STR2## ... | 08/25/1992 |
| 5132418 | Process for preparing polynucleotides This invention is a process for the production of oligonucleotides which comprises: (a) converting an inorganic polymer into a coupling agent-polymer; (b) combining the coupling agent-polymer with a blocked nucleoside to obtain a blocked nucleoside-modified su... | 07/21/1992 |
| 5110344 | Process for the hybridization of cotton Methods are disclosed for rendering cotton plants male sterile through application of isothiazole plant growth regulators without causing substantial female sterility or loss of reproductive vigor. Processes for effecting the hybridization of cotton emplo... | 05/05/1992 |
| 5110345 | Process for the hybridization of cotton Methods are disclosed for rendering cotton plants male sterile through application of isothiazole plant growth regulators without causing substantial female sterility or loss of reproductive vigor. Processes for effecting the hybridization of cotton emplo... | 05/05/1992 |
| 5098926 | 6-substituted mitomycin analogs Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a radical of the fo... | 03/24/1992 |
| 5093246 | RNA ribozyme polymerases, dephosphorylases, restriction endoribo-nucleases and methods RNA enzymes or ribozymes can act as endoribonucleases, catalyzing the cleavage of RNA molecules with a sequence specificity of cleavage greater than that of known ribonucleases and approaching that of the DNA restriction endonucleases, thus serving as RNA... | 03/03/1992 |
| 5049547 | Composition for stimulating integumental melanocytes A pharmaceutically active composition comprising a pharmaceutically acceptable carrier and one or more alpha-MSH or analogues thereof for use in the stimulation of integumental melanocytes in vertebrates in order to bring about the production of melanin i... | 09/17/1991 |
| 5037746 | RNA ribozyme polymerases, and methods A catalytic RNA (ribozyme) derived from an intervening sequence (IVS) RNA of Tetrahymena thermophila will catalyze an RNA polymerization reaction in which pentacytidylic acid (C5) is extended by the successive addition of mononucleotides derive... | 08/06/1991 |
| 5023149 | Electrochemistry employing polyaniline Electrochemical cells including secondary batteries and fuel cells are provided employing polyanilines having improved reversibility, stability and electrochemical properties. In accordance with a preferred embodiment polyaniline is employed as a cathode ... | 06/11/1991 |
| 5023253 | 6-substituted mitomycin analogs Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula V, ##STR1## wherein: Y is hydrogen of lower alkyl; and X is a radical of the for... | 06/11/1991 |
| 4987071 | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods RNA enzymes or ribozymes can act as endoribonucleases, catalyzing the cleavage of RNA molecules with a sequence specificity of cleavage greater than that of known ribonucleases and approaching that of the DNA restriction endonucleases, thus serving as RNA... | 01/22/1991 |
| 4973679 | Process for oligonucleo tide synthesis using phosphormidite intermediates A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.... | 11/27/1990 |
| 4941477 | Method and apparatus for detection of deception A method and apparatus for detecting concealment of hidden information in interrogative polygraphy is described which employs Event Related Brain Potentials (ERP). Various stimuli are presented to a subject and the P300 components of the subject's ERP's a... | 07/17/1990 |
| 4940666 | Process and defined medium for growth of human epidermal keratinocyte cells Disclosed are novel methods and materials for generating in vitro cultured populations of human epidermal keratinocyte cells having a characteristic colony-forming efficiency of greater than 20%. Novel media preparations and procedures are disclosed that ... | 07/10/1990 |
| 4940658 | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency Method for determining levels of sulfhydryl amino acids, particularly total homocysteine levels in samples of body tissue from warm-blooded animals, methods of detecting cobalamin and folic acid deficiency using an assay for total homocysteine levels, and... | 07/10/1990 |
| 4888341 | 6-substituted mitomycin analogs Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is a radical of the fo... | 12/19/1989 |
| 4885304 | Mitomycin analogs Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R1, and R2 are the same or different an... | 12/05/1989 |
| 4873196 | Protoplasts of temperature-sensitive strains of neurospora crassa OS-1 This invention concerns conditional protoplasts of temperature-sensitive variants of the osmotic-1 mutant strain of Neurospora crassa, and method of making same.... | 10/10/1989 |
| 4866038 | Method of stimulating integumental melanocytes by topical application of analogs of alpha-msh A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.... | 09/12/1989 |
| 4856009 | Method and appartus for laser control The disclosure is directed to a method and apparatus for precisely controlling the frequency of a laser, and for precise control of distance. In a disclosed embodiment, a laser beam is split, modulated to obtain a frequency differential, and coupled to an... | 08/08/1989 |
| 4847207 | Process for detection of organosulfur compounds and apparatus therefor An organosulfur compound is detected and/or quantified, optionally in admixture with one or more other compounds, by reacting the organosulfur compound with gaseous fluorine at sub-atmospheric pressure and observing the chemiluminescence which develops. D... | 07/11/1989 |
| 4823145 | Curved microstrip antennas A thin planar curved microstrip antenna is described which exhibits substantially constant input impedance characteristics over a wide frequency band. The impedance characteristic is achieved by shaping the ground surface such that the ratio of the width ... | 04/18/1989 |
| 4819652 | C W and pulse Doppler diagnostic system In an interlaced pulse-echo and range-gated Doppler system, an ultrasound transmitter generates a train of constant repetition rate echo pulse interlaced with a Doppler pulse train of plural bursts. The time duration between each burst and the preceding r... | 04/11/1989 |
| 4820595 | Electrochemistry employing polyaniline Electrochemical cells including secondary batteries and fuel cells are provided employing polyanilines having improved reversibility, stability and electrochemical properties. In accordance with a preferred embodiment polyaniline is employed as a cathode ... | 04/11/1989 |
| 4801299 | Body implants of extracellular matrix and means and methods of making and using such implants A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such... | 01/31/1989 |
| 4801512 | Reversible electrochemical doping of conjugated polymers and secondary batteries based thereon Conjugated polymers are doped with ionic dopant species to a preselected room temperature electrical conductivity ranging from that characteristic of semiconductor behavior to that characteristic of metallic behavior, by means of reversible electrochemica... | 01/31/1989 |
| 4797503 | Chiral 1-cyanoalkoxy 4-hydroxyphenyl derivatives The preparation and properties of liquid crystal compounds having an achiral core and chiral tail units composed of the 1-cyanoalkoyl grouping (chiral cyanohydrin ethers) are described. The newly made compounds are shown to be useful as components of ferr... | 01/10/1989 |
| 4789751 | Synthesis of new liquid crystal materials possessing phenylbenzoate or biphenyl core units and (2,3)-epoalkyloxirane methanol chiral tails Ferroelectric (chiral) smectic liquid crystal compounds having an achiral core and chiral tail units derived from (2,3)-epoxyalkyloxiranemethanols possess a high ferroelectric polarization density. These newly made compounds exhibit high speed, multistate... | 12/06/1988 |
| 4786374 | Electro-chemical sensors and methods for their manufacture and use Improved electrochemical sensors are provided through isostatic processing techniques. Improved electrochemical sensors, especially those suitable for use in metallurgical melts, having, at once, long-term stability, improved sensitivity, and improved phy... | 11/22/1988 |
| 4786597 | Method and apparatus for conducting catalytic reactions with simultaneous product separation and recovery Catalytic chemical and biochemical conversion reactions are carried out in a novel compartmentalized catalytic reactor which enables the energy-efficient coupling of the conversion reaction with various energy-consuming post-conversion operations. The cat... | 11/22/1988 |
| 4777280 | Phenylbenzoate 1-cyanoalkoxy compounds The preparation and properties of liquid crystal compounds having an achiral core and chiral tail units composed of the 1-cyanoalkoyl grouping (chiral cyanohydrin ethers) are described. The newly made compounds are shown to be useful as components of ferr... | 10/11/1988 |
| 4772884 | Independent sustain and address plasma display panel An AC gas discharge display panel is described which employs the phenomenon of plasma spreading. In the panel, plasma spreading or "coupling" is employed to couple the plasma to an addressed cell to one of a plurality of pixels to be illuminated. The spre... | 09/20/1988 |
| 4769331 | Recombinant methods and materials Specific DNA sequence insertions, deletions and substitutions (i.e., combinations of sequence deletion and insertion) in eukaryotic cell or viral genomes are stably effected through use of selectable DNA sequences comprising a herpesvirus thymidine kinase... | 09/06/1988 |
| 4758597 | Carenadiol and derivatives The present invention relates to new synthetic compounds of the cannabinoid class, specifically carenadiol and its derivatives. This compound and its derivatives have been shown to have biological activity which indicates their usefulness in the treatment... | 07/19/1988 |
