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| Number | Title | Issue Date |
| 7928284 | Methods and animal model for analyzing age-related macular degeneration Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also pr... | 04/19/2011 |
| 7919699 | Nanotubes as mitochondrial uncouplers A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental ... | 04/05/2011 |
| 7919082 | High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechan... | 04/05/2011 |
| 7892584 | Online, continuous sensor and method for curd moisture content control in cheese making A method is provided for improving quality of cheese produced from a milk batch. A light beam from an incident light source impinges onto a surface of the milk batch, and light backscatter is optically detected during a coagulation process and correlated to an optim... | 02/22/2011 |
| 7892537 | High activity mutants of butyrylcholinesterase for cocaine hydrolysis Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE poly... | 02/22/2011 |
| 7886959 | Security monitoring system for a bulk foodstuff transport container A security monitoring system provides for the secure transport of a bulk foodstuff container. The system includes an electromechanical locking mechanism allowing access by only authorized persons, a positional locator for determining the geographical position of the... | 02/15/2011 |
| 7884263 | Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involv... | 02/08/2011 |
| 7880881 | Method of improving cheese quality A method is provided for improving the quality of cheese produced from a curd and whey mixture. The method comprises the steps of monitoring the curd and whey mixture during syneresis processing to collect color data, comparing the color data to a predetermined stan... | 02/01/2011 |
| 7868222 | Transfected mosquito vectors A method is provided for producing an artificial infection in a Culicidae (mosquito) species. The mosquitoes include species within the subfamilies Culicinae and Anophelinae, and the species include Aedes albopictus, Aedes aegypti and Aedes polynesiensis | 01/11/2011 |
| 7851172 | Biomarkers of mild cognitive impairment and alzheimer's disease A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer's disea... | 12/14/2010 |
| 7842493 | Cell lines having enhanced cell longevity and protein expression It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression ... | 11/30/2010 |
| 7816407 | Agmatine and agmatine analogs in the treatment of epilepsy, seizure, and electroconvulsive disorders Pharmaceutical preparations containing of agmatine, congeners, analogs or derivatives thereof for use in preventing or treating epilepsy, seizures and other electroconvulsive disorders are provided. Embodiments include administering an effective amount of agmatine, ... | 10/19/2010 |
| 7815911 | Compositions and methods for treating infection Compositions and methods for treating a Yersinia pestis (Y. pestis) infection are provided. Compositions and methods of for inducing an immune response in a subject are provided. Composition can include a YadC polypeptide. ... | 10/19/2010 |
| 7803392 | pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules The present invention relates to pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules of interest, namely active pharmaceuticals. The gels comprise a pharmaceutically acceptable pH-sensitive polym... | 09/28/2010 |
| 7799904 | Gilvocarcin gene cluster, recombinant production and use thereof A nucleic acid molecule encoding the gilvocarcin V gene cluster and subunits thereof. Recombinant vectors and host cells comprising a nucleic acid compound encoding the gilvocarcin V gene cluster or subunits thereof. Host cells comprising recombinant vectors encodin... | 09/21/2010 |
| 7786275 | Identification of a unique core domain of Par-4 sufficient for selective apoptosis induction in cancer cells The present invention relates to Par-4 mutants which cause apoptosis in cancer cells which are sensitive to Par-4 and also induce apoptosis in cancer cells which are resistant to Par-4. The present invention also relates to methods of using the Par-4 mutant to treat... | 08/31/2010 |
| 7785553 | Reducing explosive potential of ammonium nitrate A method for reducing the explosive potential of a nitrogen-based fertilizer product includes coating the product with a composition including a coal combustion by-product. The coal combustion by-product may be oxidized prior to coating the product, and further may ... | 08/31/2010 |
| 7776835 | Trans-excision-splicing ribozyme and methods of use A group I intron-derived ribozyme which binds RNA in trans, excises an internal segment from within the RNA, and splices the remaining 5′ and 3′ ends of the RNA back together (the trans-excision-splicing reaction) is disclosed. The excised segment can be as long... | 08/17/2010 |
| 7759468 | Bioactive peptide-based probes A method for preparing a site-specific peptide probe, wherein the peptide is specific to a receptor, includes modifying a marker to include a tether molecule and covalently binding the tether molecule to the peptide. The present invention also provides a labeled pro... | 07/20/2010 |
| 7757697 | Method for reducing nitrosamines in tobacco Nitrosamines are reduced in tobacco by treating a whole tobacco leaf with ferulic acid. Treatment is conducted by applying an aqueous solution of ferulic acid to the whole tobacco leaf immediately before, at, or after harvesting, or fire curing the whole tobacco lea... | 07/20/2010 |
| 7745693 | Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for identifying the same The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides. ... | 06/29/2010 |
| 7745589 | Antibodies and unnatural substrates of prenylation enzymes for use in detecting and isolating prenylated proteins Unnatural substrates of prenylation enzymens and antibodies that recognize unique moieties of prenylated proteins, which unique moieties are transferred from the unnatural substrates are used for detecting and isolating prenylated proteins, and for screening for inh... | 06/29/2010 |
| 7741574 | Particle separation/purification system, diffuser and related methods A separator and related separation methods are for intended use in separating particles having a selected charge from a particle mixture entrained in or carried by a fluid flow. The separator comprises a tubular, elongated body for receiving the fluid flow. At least... | 06/22/2010 |
| 7740840 | High activity mutants of butyrylcholinesterase for cocaine hydrolysis Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE poly... | 06/22/2010 |
| 7739056 | Biomarkers for aging A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where th... | 06/15/2010 |
| 7731957 | High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechan... | 06/08/2010 |
| 7723019 | Organic cation transporter preferentially expressed in hematopoietic cells and leukemias and uses thereof A novel organic cation transporter (OCT) gene, OCT 6, and use thereof is described. The OCT6 gene is preferentially expressed in human hematopoietic tissues, including CD34+ cells and leukemia cells. Its narrow tissue distribution, substrate specificity, and close h... | 05/25/2010 |
| 7705119 | Compositions and methods useful for treating circulatory and hypovolemic shock Polypeptides, compositions, and methods for treating shock are described. A isolated polypeptide, Deltorphin-E, can be administered without concomitant fluid resuscitation, before, concurrently with, or after the onset of shock or the occurrence of an event that cre... | 04/27/2010 |
| 7691872 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds The present invention provides methods and formulations for optimizing the anti-cancer and anti-HIV activities of a camptothecin drug, including camptothecin and its related analogs including 9-aminocamptothecin and 9-nitrocamptothecin. The invention involves method... | 04/06/2010 |
| 7659078 | Method and kit for determination of prostacyclin in plasma A solid-phase immunoassay for 6-keto-Prostaglandin F1α, the stable hydrolysis product of prostacyclin (Prostaglandin I2) is disclosed. Prostacyclin, a potent vasodilator with anti-platelet and anti-proliferative properties is an effective trea... | 02/09/2010 |
| 7651678 | Methods to impair hematologic cancer progenitor cells and compounds related thereto Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leu... | 01/26/2010 |
| 7643354 | Neural network model for instruments that store and retrieve sequential information A method and design is provided for distributing and storing sets of temporally ordered information in a systematic and sequential fashion. This method is based on a model of how the brain functions in the distribution and storage of temporally ordered memories, but... | 01/05/2010 |
| 7642369 | Epoxyketone-based immunoproteasome inhibitors An efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative, is provided, which includes the synthesis of the intermediate compound, a hydroxymethyl-substituted enone. In addition, a method is provided for synthesizing inhibitors... | 01/05/2010 |
| 7629160 | Vectors and methods for enhanced cell longevity and protein expression It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression ... | 12/08/2009 |
| 7625951 | Stimuli-responsive hydrogel microdomes integrated with genetically engineered proteins for high-throughput screening of pharmaceuticals A hydrogel microdome that can swell in response to a stimuli or target molecule is formed by polymerizing a mixture comprising a monomer capable of forming a hydrogel with a biopolymer. An array of hydrogel microdomes can be formed on a substrate by microspotting th... | 12/01/2009 |
| 7618815 | Viral vectors useful in soybean and methods of use The invention provides Bean pod mottle virus (BPMV) vectors useful for expression of heterologous proteins in plants such as soybean. The BPMV vectors are also useful for virus-induced gene silencing. The invention also provides methods for expressing a heterologous... | 11/17/2009 |
| 7611628 | Aligned nanotubule membranes A method is provided for producing a permeable membrane, comprising the steps of aligning a plurality of hollow nanotubules to form a mat, coating the mat with a continuous polymer matrix to form a membrane. The membrane is etched (a) to open the plurality of hollow... | 11/03/2009 |
| 7605300 | Genetic insulator for preventing influence by another gene promoter A 16 bp polynucleotide sequence of Arabidopsis thaliana is a genetic insulator that can effectively isolate a transgene from positional effects of neighboring gene activities in transgenic plant cells. ... | 10/20/2009 |
| 7604930 | Methods and devices for cryopreservation of biological cells and tissues Novel methods, compositions, and devices for achieving optimal cooling of living cells during cryopreservation are disclosed. In one aspect, the method comprises gradually cooling the cell to a first predetermined temperature, followed by rapidly cooling the cell to... | 10/20/2009 |
| 7595430 | Methods and animal model for analyzing age-related macular degeneration Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also pr... | 09/29/2009 |
