"Flight by machines heavier than air is unpractical and insignificant, if not utterly impossible."
Simon Newcomb, astronomer ; Said in 1902, less than two years before the first flight at Kitty Hawk
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| Number | Title | Issue Date |
| 8174259 | Apparatus and method for determining magnetic properties of materials Apparatus for determining magnetic properties of materials comprises a portable probe (1), an equipment trolley (2) holding cryogenics and electronics and connecting cables (3). The probe (1) comprises a drive coil (4) and a correc... | 05/08/2012 |
| 8137409 | Method of installing a transcutaneous prosthesis A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachm... | 03/20/2012 |
| 8034766 | Compositions and methods for prion decontamination The invention relates to compositions and methods for prion degradation, decontamination or disinfection. The composition comprises an oxidizing agent, one or more proteases and a surfactant such as an ionic surfactant/detergent. The method comprises contacting a pr... | 10/11/2011 |
| 7790761 | Blockade of voltage dependent sodium channels Compounds of Formula I and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis. ... | 09/07/2010 |
| 7696382 | Modulator The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR1 or NR1R2 wherein each of R1 and R2 is independently H, or a hydrocarbyl group; X is an ... | 04/13/2010 |
| 7579009 | Whole bacterial cells as immune modulator An immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and Nocardioides, wherein said immune modulator composition in use modifies ... | 08/25/2009 |
| 7563586 | Method of identifying a modulator of a voltage-gated sodium channel using cells expressing Nav1.8 and p11 The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound under conditions where the VGSC and the p11 peptide are capable of for... | 07/21/2009 |
| 7473771 | Polypeptide hormone phosphatonin The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates... | 01/06/2009 |
| 7459300 | Polypeptide Hormone Phosphatonin The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates... | 12/02/2008 |
| 7428254 | Athermalisation of tuneable lasers This invention describes a technique and apparatus to use any tuneable laser to generate a specified output frequency without controlling its temperature. This technique only involves a thermal sensor and a controller a determine the current(s) of voltage(s) applied... | 09/23/2008 |
| 7143103 | Method and apparatus for monitoring and maintaining the consistency of distributed documents A computer network comprising a plurality of terminals (1–4) connected via a communications network 5 is provided. In each of the terminals (1–4) application software (15) for generating XML source documents is provided. XML source do... | 11/28/2006 |
| 7099721 | Method and apparatus for producing a biomaterial product A development tool (2) includes a plurality of measuring tools (71) to (76) and an industrial process simulation device (60). The simulation device (60) simulates a whole industrial scale bioprocess in order to obtain acceptable op... | 08/29/2006 |
| 7098185 | Polypeptide hormone phosphatonin The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates... | 08/29/2006 |
| 7095505 | Optical interferometer sensor array An interferometer sensor has a two-dimensional sensor head (1) comprising a polymer film (4) of substantially uniform thickness. An interrogating signal (12) is provided to the sensor head, the interrogation signal extending across the area of t... | 08/22/2006 |
| 7014661 | Transcutaneous prosthesis A transcutaneous prosthesis is disclosed comprising a first component (1) shaped for implantation into a bone (2), a second component (4) intended for location between the bone (2) and the skin, and a third component (5) intended f... | 03/21/2006 |
| 7009056 | Blockade of voltage dependent sodium channels Compounds of formula (I), and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis. ... | 03/07/2006 |
| 6928881 | Method and apparatus for monitoring structural fatigue and use An electronic stress monitoring device (1) is provided that is arranged to detect and record measurements of stress experienced by a structure (2) to which the stress history unit is attached, with the measurement and recordal of stress occurring at su... | 08/16/2005 |
| 6911649 | Particle generator Energy tunable solid state sources of neutral particles are described. In a disclosed embodiment, a halogen particle source includes a solid halide sample, a photon source positioned to deliver photons to a surface of the halide, and a collimating means positioned t... | 06/28/2005 |
| 6849076 | Surgical distraction device A surgical distraction device is provided for applying extending or tensioning force non-invasively to a patient's skeleton or to an implant which comprises anchoring means for attaching first and second components of the device to a bone or to adjoining bones, said... | 02/01/2005 |
| 6839496 | Optical fibre probe for photoacoustic material analysis A probe comprises an excitation source and a double-core optical fiber. A pulsed laser signal (20) of the excitation sources supplied to the outer core (42) at one end of the optical fiber. The other end is provided with an interferometer film (18 | 01/04/2005 |
| 6821946 | Repair of nerve damage The invention provides a method of treating nerve damage involving administering to the damaged nerve an effective non-toxic amount of an MGF (mechano-growth factor) Insulin-like Growth Factor I (IGF-I) isoform which includes amino acid sequences encoded by nucleic ... | 11/23/2004 |
| 6818745 | Polypeptide hormone phosphatonin The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates... | 11/16/2004 |
| 6813401 | Fabrication of fabry-perot polymer film sensing interferometers A method of forming an interferometer film for an interferometer sensor comprises forming a parylene polymer layer (8) of substantially uniform thickness directly on an interferometer substrate (4;45), the layer forming the interferometer film. Since t... | 11/02/2004 |
| 6796877 | Abrading machine A machine for abrading or polishing a workpiece comprises a holding surface holding the workpiece, a head member arranged along a rotation axis to rotate about the rotation axis, a working member having a surface for abrading or polishing the workpiece arranged on t... | 09/28/2004 |
| 6673900 | Polypeptide hormone-phosphatonin The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention furt... | 01/06/2004 |
| 6664290 | Oral or vaginal administration of mesoprostol in third stage labor This invention relates to a method of limiting postpartum hemorrhage comprising administering orally a single effective dose of misoprostol to a woman during the third stage of labor.... | 12/16/2003 |
| 6595746 | Mixed flow pump A highly efficient mixed flow pump can prevent flow separation which is likely to occur in a corner portion of a flow passage of a diffuser section. The mixed flow pump includes a casing having an axis and defining an impeller section and a diffuser secti... | 07/22/2003 |
| 6526299 | Spectrum processing and processor An elastic scattering spectrum taken from human tissue is taken and preprocessed by dividing the absorption spectrum into a plurality of wavelength ranges and fitting the measured absorption spectrum to the absorption of predetermined absorption component... | 02/25/2003 |
| 6521230 | CD25 binding molecules Monoclonal antibodies to the CD25 antigen are characterized by the amino acid sequence of their hypervariable regions. Initially produced in murine form, they may be converted to chimeric or humanized forms, immunoconjugates or antibody fragments (general... | 02/18/2003 |
| 6516833 | Helically wound reinforcing components for flexible tubular conduits This invention relates to flexible tubular conduits or pipes particularly in situations where the conduits need to withstand relatively high pressures. In such cases, the conduits are reinforced by helically wound armor which is compliant in flexure, and ... | 02/11/2003 |
| 6508626 | Turbomachinery impeller Disclosed is an impeller for a turbomachine. The impeller comprises a hub, full blades equidistantly disposed on the hub in a circumferential direction, and a splitter blade disposed between each adjacent two of the full blades. The splitter blade is shap... | 01/21/2003 |
| 6469139 | Modified human chorionic gonadotropin (ଲ-hCG) proteins and their medical use The present invention relates to modified human chorionic gonadotropin (ଲ-hCG) proteins and their medical use as immunological contragestatives. The modification causes a reduction in the cross-reactivity of the modified ଲ-hCG protein with lut... | 10/22/2002 |
| 6444644 | Anticoagulant peptide fragments derived from apolipoprotein B-100 The present invention provides a peptide compound of formula Z1 --K--A--Q--X1 --K--K--N--K--H--R--H--S--X2 --T--Z2 (SEQ ID NO:1) where: X1 represents S or Y, X2 represents T or I, Z1 ... | 09/03/2002 |
| 6383487 | Methods of treatment using CD25 binding molecules Novel monoclonal antibodies to the CD25 antigen are characterized by the amino acid sequence of their hypervariable regions. Initially produced in murine form, they may be converted to chimeric or humanized forms, immunoconjugates or antibody fragments (g... | 05/07/2002 |
| 6372501 | Glucose responsive ଲ-cell line The present invention provides an immortalized insulin producing human ଲ-cell which may be rendered glucose responsive by suitable bioengineering methods. The invention also provides a method for producing an immortalized glucose responsive insulin ... | 04/16/2002 |
| 6358259 | Device for use in tying knots A thread guide device is provided which is adapted to be removably or fixedly mounted on the distal end of an endoscope, or which is an integral part thereof. Alternatively, the device may comprise a head joined to the distal end of an elongate example in... | 03/19/2002 |
| 6248320 | HSV strain lacking functional ICP27 and ICP34.5 genes The present invention provides a herpes simplex virus strain which lacks a functional ICP34.5 gene and a functional ICP27 gene. It also provides the use of a herpes simplex virus strain which lacks a functional ICP34.5 gene and a functional ICP27 gene in ... | 06/19/2001 |
| 6221842 | Method of treating muscular disorders The invention provides pharmaceutical compositions comprising particular isoforms of human insulin-like growth factor I (IGF-I). An isofoim of the invention is an IGF-I polypeptide corresponding to the mechanical-stimulation-specific, stretch-inducible IG... | 04/24/2001 |
| 6142631 | Reduced logMAR visual acuity test chart An improved visual acuity chart is disclosed. The ratio of the size of the optotypes of neighbouring lines on the chart is a constant and preferably the size decrement between lines is 0.1 logMAR. Each line of optotypes has two, three or four optotypes, p... | 11/07/2000 |
| 6136528 | Multiple sclerosis virus The present invention provides a polynucleotide in substantially isolated form comprising a sequence of nucleotides which is capable of selectively hybridizing to the genome of the human multiple sclerosis virus (HMSV) or the complement thereof, wherein H... | 10/24/2000 |