Assignee: Trustees of the University of Pennsylvania

Location: Philadelphia, PA
No. of patents: 240

Number	Title	Issue Date
8124056	High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid and/or cholesterol processing in a vertebrate; screening for genetic mutations ...	02/28/2012
8101564	Methods for regulating osteoclast differentiation and bone resorption using LRRc17 Provided is a purified, negative regulator of osteoclast differentiation and bone resorption, specifically LRRc17. Further provided are methods and compositions for treating degenerative bone disorders, and treatments and prophylactic approaches for regulating bone ...	01/24/2012
7943321	Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.	05/17/2011
7902341	Methods and compositions for modulating somatolactogenic functions Compositions containing cyclophilin B, mutants of cyclophilin B or inhibitors of cyclophilin B and methods of using these compositions to modulate somatolactogenic function are provided. ...	03/08/2011
7892819	Mesoscale polynucleotide amplification devices Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide amplification reaction. The devices are provided with a substrate microfabricated to include a polynucleotide amplification reaction, chamber, having at leas...	02/22/2011
7837997	Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers. ...	11/23/2010
7771985	Mesoscale detection structures Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port...	08/10/2010
7704736	Compositions for the derivation of germ cells from stem cells and methods of use thereof Compositions and methods are provided for the reproducible derivation of germ cells and oocytes and spermatogonia therefrom. Also provide are methods of use of the same in reproductive and therapeutic cloning protocols. ...	04/27/2010
7691812	Methods for inhibiting growth of prolactin-responsive cancer cells with cyclosporine A or other cyclophilin inhibitors Methods are provided for inhibiting growth of prolactin-responsive cancer cells and treating prolactin-responsive malignancies via administration of an agent such as cyclosporine A which directly inhibits an enzymatic activity of a cyclophilin. ...	04/06/2010
7683236	Enhanced production of cloned mammals by zona pellucida-free homologous mammalian embryo aggregation Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and therapeutic cloning protocols. ...	03/23/2010
7670763	Method of determining sperm capacitation This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with ...	03/02/2010
7662629	Peptide scaffolds for transfer of molecules into eukaryotic cells Compositions and methods of using compositions with a nuclear targeting peptide containing a nonclassical nuclear localization signal to deliver selected molecules to the nucleus of eukaryotic cells are provided. The compositions are particularly useful in gene tran...	02/16/2010
7597907	Antioxidant polymer nanocarriers for use in preventing oxidative injury The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for...	10/06/2009
7550268	Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.	06/23/2009
7514219	Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be used to distinguish between primary squamous cell carcinoma of the l...	04/07/2009
7494770	Mesoscale polynucleotide amplification analysis Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide polymerization reaction. The devices comprise a substrate microfabricated to define a sample inlet port and a mesoscale flow system, which extends from the i...	02/24/2009
7488467	High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholi...	02/10/2009
7430323	Method and apparatus for 4-dimensional image warping A method of atlas mapping and an apparatus for image mapping are provided. The method includes generating a four dimensional template, linearly transforming the four dimensional representation of a subject to the four dimensional template, generating attribute vecto...	09/30/2008
7402308	Method of delivering genes to the central nervous system of a mammal The invention provides a method of delivering a selected DNA sequence to the central nervous system of a mammal by administering to said mammal a neurotropic virus, said virus containing a selected DNA sequence under the control of a promoter which permits expressio...	07/22/2008
7297820	Stilbene derivatives and their use for binding and imaging amyloid plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat...	11/20/2007
7264762	Electrospinning ultrafine conductive polymeric fibers A process of making conductive polymeric fibers by electrospinning fibers from a blend of polymers dissolved in an organic solvent includes generating a high voltage electric field between oppositely charged polymer fluid in a glass syringe (4) with a capilla...	09/04/2007
7262290	Diagnostic markers for multiple epilepsy phenotypes A mammalian KIR 4.1 gene and gene products which are predictive of a susceptibility or predisposition to neurological disorders such as multiple epilepsy phenotypes are provided. Methods of predicting an individual's susceptibility in developing or having a neurolog...	08/28/2007
7247614	Composition and method for modulating somatolactogenic function A human prolactin-binding protein and compositions and methods using this protein are provided. ...	07/24/2007
7244704	Peptide scaffolds for transfer of molecules into eukaryotic cells Compositions and methods of using compositions with a nuclear targeting peptide containing a nonclassical nuclear localization signal to deliver selected molecules to the nucleus of eukaryotic cells are provided. The compositions are particularly useful in gene tran...	07/17/2007
7172760	Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers. ...	02/06/2007
7160994	Osteoclast-specific genes and proteins and uses thereof Isolated nucleic acid and amino acid sequence for osteoclast-specific genes and proteins are provided. Methods for using these osteoclast-specific genes and proteins in the detection and isolation of osteoclasts, in production of antibodies specific to osteoclasts a...	01/09/2007
7160676	Method of determining sperm capacitation This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with ...	01/09/2007
7157087	Enhancement of intracellular delivery and tissue targeting of drugs and genes A method for enhancing intracellular delivery of effector molecules is provided. The method involves modifying selected antibodies with biotin and streptavidin, conjugating these antibodies with an effector molecule, and delivering the conjugated effector to an intr...	01/02/2007
7148269	Interfacial polymer incorporation of nanotubes A method for producing a composite material containing nanotubes and an interfacial polymer, and a composite material made by the method. The method involves contacting two mutually insoluble monomer solutions, at least one of which contains nanotubes, to provide an...	12/12/2006
7122313	Methods and kits for identifying and quantifying RNAs and DNAs associated with RNA and DNA binding proteins Methods and kits for identifying RNAs and DNAs associated with an RNA or DNA binding protein via a detector specific for the binding protein or protein bound thereto which is linked to an oligonucleotide capable of directing the synthesis of cDNA copies of RNA or DN...	10/17/2006
7119185	Hormonally up-regulated, neu-tumor-associated kinase This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary developm...	10/10/2006
7115371	Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.	10/03/2006
7105306	Methods and compositions for modulating somatolactogenic functions Compositions containing cyclophilin B, mutants of cyclophilin B or inhibitors of cyclophilin B and methods of using these compositions to modulate somatolactogenic function are provided. ...	09/12/2006
7087060	Methods for obtaining hemostasis of percutaneous wounds This invention relates to novel methods, kits, and devices for stopping hemorrhaging of percutaneous wounds. The inventive subject matter involves insertion of a purse-string suture around the wound, insertion of the free two ends of the suture through a tension col...	08/08/2006
7087436	Membrane countercurrent exchanger and membrane inlet mass spectrometer for the analysis of gas partial pressure in liquid samples A method and apparatus for the analysis of blood or other liquids by mass spectrometry to determine the partial pressures of gases and other volatile substances dissolved in the blood or other liquid in a manner independent of the solubility of the gases in the bloo...	08/08/2006
7052685	Methods for treatment of cutaneous T-cell lymphoma A method and composition for treatment of advanced cutaneous T cell lymphoma is provided which involves administration of recombinant interleukin-12. ...	05/30/2006
7053121	Compositions and methods for regulating circadian rhythms The present invention provides methods of effecting a change in the core circadian clock by modulating retinoid nuclear receptors. ...	05/30/2006
7041287	Compositions and methods for selective dissolution of nascent intravascular blood clots Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed intravascularly, with minimal risk of unwanted dissolution of pre-existing ...	05/09/2006
7011827	Compositions and methods for producing and using homogenous neuronal cell transplants Methods of treating individuals suspected of suffering from diseases, conditions or disorders of the Central Nervous System including nerve damage are provided wherein stable, homogeneous post-mitotic human neurons are into the individual's brain or at or near a sit...	03/14/2006
6982156	Compositions and methods modulating variola and vaccinia virus Antibodies directed to SPICE and VCP which may be used for detection, prevention, and treatment of variola virus or vaccinia virus are provided. Recombinant SPICE and VCP proteins are also provided which are used for enhancing the immune response to variola or vacci...	01/03/2006

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Assignee: Trustees of the University of Pennsylvania