Assignee: Trustees of Tufts College

Location: Boston, MA
No. of patents: 23

Number	Title	Issue Date
8124580	Apolipoprotein A1 mimetics and uses thereof The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also provides pharmaceutical compositions and methods of treatment for eleva...	02/28/2012
7871459	Apparatus and methods for non-regenerative and regenerative hot gas desulfurization Disclosed is a doped cerium oxide sorbent that can effectively and regenerably remove H2S in the temperature range of about 500° C. to about 1000° C. Regenerable sorbents (e.g., ZnO, La2O3, CeO2) and methods of using the...	01/18/2011
7612166	Fluorous capping reagents and methods for peptide purification Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbo...	11/03/2009
7247437	Vibrionaceae replication factors and methods of use thereof The invention relates to compositions, methods and kits useful in modulating bacterial cell DNA replication and for treating pathogenic bacterial. ...	07/24/2007
7189697	Compositions and uses of a galectin for treatment of dry eye syndrome Methods for the therapeutic treatment of dry eye in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-1 protein, a galectin-3, a galectin-7 protein and/or a galectin-8 protein are provide...	03/13/2007
7115884	Self-encoding fiber optic sensor Self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of s...	10/03/2006
6994992	Androgen-induced suppressor of cell proliferation and uses thereof The invention provides novel AS3 nucleic acid sequences, AS3 polypeptides, anti-AS3 antibodies, and methods for modulating cell proliferation and detecting compounds that modulate cell proliferation. Diagnostic and therapeutic methods utilizing compositions of the i...	02/07/2006
6967021	Use of Galectin-3 to promote the re-epithelialization of wounds Methods for the therapeutic treatment of epithelial wounds in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-3 protein and/or a galectin-7 protein are provided. Pharmaceutical composit...	11/22/2005
6723055	System for measuring respiratory function The present invention relates to a system for measuring respiratory function of living organisms. More particularly, signals indicative of the change in lung volume, defined as active and passive work, required to breathe and the airflow through the respiratory syst...	04/20/2004
6448006	Methods and compositions for reducing bacterial tolerance to antibacterials disinfectants and organic solvents The invention relates to methods and compositions for manipulating bacterial resistance to non-antibiotic antibacterial compositions, disinfectants and organic solvents. The invention provides methods for rendering bacterial cells susceptible to non-antib...	09/10/2002
6410041	Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high extracellular pH. Furthermore, the methods relate to the unexpected...	06/25/2002
6287340	Bioengineered anterior cruciate ligament The present invention provides a method for producing an anterior cruciate ligament ex vivo. The method comprises seeding pluripotent stem cells in a three dimensional matrix, anchoring the seeded matrix by attachment to two anchors, and culturing the cel...	09/11/2001
6228581	Human intronic and polymorphic SR-BI nucleic acids and uses therefor The present invention is based at least in part on the discovery of the genomic structure of the human SR-BI gene and on the identification of polymorphic regions within the gene. Accordingly, the invention provides nucleic acids having a nucleotide seque...	05/08/2001
6210910	Optical fiber biosensor array comprising cell populations confined to microcavities A biosensor, sensor array, sensing method and sensing apparatus are provided in which individual cells or randomly mixed populations of cells, having unique response characteristics to chemical and biological materials, are deployed in a plurality of micr...	04/03/2001
6207384	Systematic identification of essential genes by in vitro transposon mutagenesis The invention features a general system for the identification of essential genes in organisms. This system is applicable to the discovery of novel target genes for antimicrobial compounds, as well as to the discovery of genes that enhance cell growth or ...	03/27/2001
6200737	Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure The present invention is a photodeposition methodology for fabricating a three-dimensional patterned polymer microstructure. A variety of polymeric structures can be fabricated on solid substrates using unitary fiber optic arrays for light delivery. The m...	03/13/2001
6037333	Microbe-inhibiting compositions Microbe-inhibiting compositions including N-acetylglucosamine and methods of using them....	03/14/2000
6023540	Fiber optic sensor with encoded microspheres A microsphere-based analytic chemistry system is disclosed in which microspheres carrying different chemical functionalities may be mixed together while the ability is retained to identify the functionality on each bead using an optically interrogatable e...	02/08/2000
5998578	Biologically active fragments of IL-1ଲ The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synt...	12/07/1999
5510462	IL-1ଲprotein precursor The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synt...	04/23/1996
5258372	Tetracycline activity enhancement using doxycycline or sancycline Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking ag...	11/02/1993
5021407	Tetracycline activity enhancement Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking ag...	06/04/1991
4078972	Method of purification of carboxypeptidase G₁ A method of purifying a protein-reaction mixture to obtain carboxypeptidase G1, which method comprises: passing the mixture through a column containing support material, such as carboxymethyl cellulose, under pH conditions such that the carboxy...	03/14/1978

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Assignee: Trustees of Tufts College