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| Number | Title | Issue Date |
| 8153597 | Modulators of the ABC transporter family and methods for their use An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and mimetics thereof are provided. Also provided is a method for inhibi... | 04/10/2012 |
| 8138227 | Method for inhibiting or reversing non-enzymatic glycation The present invention relates to a method for inhibiting or reversing non-enzymatic glycation of the first intermediate of a biological moiety using an α-thiolamine. By inhibiting or reversing non-enzymatic glycation of the biological moiety, conditions such as agi... | 03/20/2012 |
| 8129429 | Synthetic triterpenoids and methods of use in the treatment of disease The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second tr... | 03/06/2012 |
| 8124371 | Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for identifying agents which destabilize lysosomes are also provided as are ag... | 02/28/2012 |
| 8114626 | Yeast strain and method for using the same to produce nicotinamide riboside The present invention embraces a fungal strain deficient in nicotinamide riboside import and salvage and use thereof for producing nicotinamide riboside. Methods for producing nicotinamide riboside and a nicotinamide riboside-supplemented food product using the stra... | 02/14/2012 |
| 8106028 | MicroRNA-21 antagonists and its target PDCD4 for use in the treatment of a glioma The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma. ... | 01/31/2012 |
| 8097249 | Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate D4+ and CD8+ T cell immunity The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregula... | 01/17/2012 |
| 8084217 | CD161 ligand, pilar, for modulating activation and proliferation of T cells The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly up-regulated on both CD4 and CD8 T cells upon TCR engagement and increases ... | 12/27/2011 |
| 8068898 | Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissues This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying... | 11/29/2011 |
| 8067583 | Method for synthesizing furanosteroids The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole to produce a furo[2,3-b]phenol derivative which is elaborated by inter... | 11/29/2011 |
| 8067394 | Synthesis and biological activities of new tricyclic--enones (TBEs) This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferatio... | 11/29/2011 |
| 8034955 | Therapeutic compounds and methods of use Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. ... | 10/11/2011 |
| 8030446 | Mutant proline-and-arginine rich peptides and methods for using the same The present invention relates to mutant proline-and-arginine rich (PR) peptides with defined structural characteristics for use in inhibiting mammalian 20S proteasome activity and modulating expression of genes regulating the NF-κB pathway. Mutant PR peptides of th... | 10/04/2011 |
| 7994298 | Chimeric NK receptor and methods for treating cancer The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor co... | 08/09/2011 |
| 7993659 | TLR9 agonist and CD40 agonist immunostimulatory combinations The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen. ... | 08/09/2011 |
| 7955848 | MicroRNA biomarkers for human breast and lung cancer The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer. ... | 06/07/2011 |
| 7943588 | Method for preventing or treating neuropathic pain The present invention is a method for preventing or treating neuropathic pain. Using an agent to decrease the expression or activity of Toll-like receptor 4 (TLR4), behavioral hypersensitivity is attenuated thereby preventing or treating neuropathic pain in a subjec... | 05/17/2011 |
| 7939499 | Method for increasing cardiac mass and performance The present invention relates to methods of using a proline/arginine-rich peptide such as PR11 or PR39 for increasing cardiac mass or performance and in the treatment of heart failure. ... | 05/10/2011 |
| 7919500 | Bis-carbazole DNA intercalating agents for antitumor therapy The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, whe... | 04/05/2011 |
| 7906514 | Animal model and compounds identified via this model for treatment of chronic pain An animal model for chronic pain, and in particular lower back pain, is provided. Methods of identifying agents and reducing chronic pain with identified agents such as methotrexate are also provided. ... | 03/15/2011 |
| 7906294 | Prognosis and treatment of breast cancer The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival and select treatment modalities for breast cancer. The present invent... | 03/15/2011 |
| 7871776 | Compositions and methods for enhancing the identification of prior protein PrP A method for purifying PrPc, a purified preparation of PrPc and methods and kits for identifying the presence of PrPc are provided. ... | 01/18/2011 |
| 7863327 | Therapeutic compounds and methods of use Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. ... | 01/04/2011 |
| 7842468 | Methods for diagnosing and treating neuroendocrine cancer The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclose... | 11/30/2010 |
| 7803389 | mutant with enhanced homologous recombination and uses thereof The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous end-joining pathway which finds application in generating T.... | 09/28/2010 |
| 7799538 | Method for identifying agents which modulate GTPase activity involved in insulin-stimulated GLUT4 translocation The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP dom... | 09/21/2010 |
| 7790697 | Compositions and methods for inhibiting the synthesis or expression of MMP-1 The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for suppressing invasion or metastasis of a tumor cell and in the treatment, preven... | 09/07/2010 |
| 7763626 | Compositions and method for enhancing the therapeutic activity of opiods in treatment of pain Compositions and methods for inhibiting opioid tolerance and opioid withdrawal-induced hyperalgesia are provided. ... | 07/27/2010 |
| 7754865 | Compositions and methods for enhancing the identification of prion protein PrP The present invention provides compositions, methods and kits for enhancing the amplification of PrPsc for use in increasing the sensitivity of identifying the presence of PrPsc in a sample. ... | 07/13/2010 |
| 7722874 | Methods for reducing T cell responsiveness to an autoantigen with anti-gp39 antibodies and antigen presenting cells Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates con... | 05/25/2010 |
| 7691833 | Compositions and methods for preventing sporadic neoplasia in colon Compositions and methods for preventing sporadic neoplasia of the colon are provided. The compositions provided are based on administration of acetylsalicylic acid. ... | 04/06/2010 |
| 7678830 | Tricyclic-bis-enone derivatives and methods of use thereof Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral s... | 03/16/2010 |
| 7666616 | Nucleic acid sequences encoding luciferase for expression in filamentous fungi The present invention relates to genetic reporters. Specifically, the present invention is directed to a modified gene encoding a luciferase for high level expression in an organism with a bias for cytosine (C) or guanine (G) in the third position of the codon. ... | 02/23/2010 |
| 7586022 | Transgenic non-human animal model of lung tumorigenesis The present invention is a transgenic non-human animal whose genome contains a transgene containing a nucleic acid encoding a cyclin E protein operably linked to a regulatory element including a lung-specific promoter. The transgenic animals of the present invention... | 09/08/2009 |
| 7585639 | Methods for modulating ATP-binding cassette transmembrane reporter protein expression Methods and compositions for modulating cell surface protein expression are provided. The compositions of the present invention are gene constructs comprising ATP-binding cassette transmembrane reporter proteins. ... | 09/08/2009 |
| 7511025 | Compositions and methods for inhibiting the synthesis or expression of MMP-1 The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for suppressing invasion or metastasis of a tumor cell and in the treatment, preven... | 03/31/2009 |
| 7510714 | Methods for modulating angiogenesis Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be use... | 03/31/2009 |
| 7501124 | Methods of inducing T-cell non-responsiveness with anti-gp39 24-31 antibodies Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface wh... | 03/10/2009 |
| 7473774 | Kit for diagnosing and prognosticating matrix metalloproteinase-1 related disease via a matrix metalloproteinase-1 single nucleotide polymorphism Methods and kits for diagnosing and prognosticating matrix metalloproteinase-1 related disease by detecting a single nucleotide polymorphism in the promoter of the gene are provided. Also provided are methods of identifying agents which inhibit binding of transcript... | 01/06/2009 |
| 7445781 | Anti-CD40CR MR1 antibody The present invention relates to a counter-receptor, termed CD40CR, for the CD40 B-cell antigen, and to soluble ligands for this receptor, including fusion molecules comprising at least a portion of CD40 protein. It is based, at least in part, on the discovery that ... | 11/04/2008 |
