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The ice cream cone was invented at the St. Louis Worlds Fair by Ernest Hamwi in 1904. His waffle booth was next to an ice cream vendor who ran short of dishes. Hamwi rolled a waffle to hold ice cream and the cone was born.
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| Number | Title | Issue Date |
| 8183222 | Method to inhibit cell growth using oligonucleotides Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleot... | 05/22/2012 |
| 8182804 | Engineered enzymatically active bacteriophages and methods of uses thereof The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm d... | 05/22/2012 |
| 8153377 | Method for detecting and quantifying rare mutations/polymorphisms The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic ac... | 04/10/2012 |
| 8153119 | Engineered enzymatically active bacteriophage and methods for dispersing biofilms The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly ... | 04/10/2012 |
| 8137509 | Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral brønsted acids The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative ... | 03/20/2012 |
| 8093417 | Lipoxin analogs and methods for the treatment of periodontal disease This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invent... | 01/10/2012 |
| 8093288 | Genipin derivatives and uses thereof Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed. | 01/10/2012 |
| 8063535 | Nanomechanical oscillator A mechanical oscillator has components with dimensions in a sub-micron range to produce resonance mode oscillations in a gigahertz range. A major element is coupled to a minor, sub-micron element to produce large amplitude gigahertz frequency oscillation that is det... | 11/22/2011 |
| 8034567 | Quantification of gene expression The present invention relates to a method for measuring the amount of a target nucleic acid in a sample using a standard which is designed to have one base difference compared with the gene of interest or a “target nucleic acid sequence.” Use of such standard in... | 10/11/2011 |
| 7929195 | MEMS based retroreflector A deformable reflective surface is disclosed that may be used with a retroreflector to provide a modulated retroreflector. The modulated retroreflector may be used in communication systems such as optical laser communication systems wherein an incident beam is refle... | 04/19/2011 |
| 7919093 | Roles for dual endothelin-1/angiotensin II receptor (Dear) in hypertension and angiogenesis The present application is directed to the identification of mutations and/or polymorphisms in the Dual Endothelin-1/Angiotensin II Receptor (Dear) that indicate susceptibility to, or show current affliction with, hypertension. Additionally, the present invention di... | 04/05/2011 |
| 7914778 | Methods of treatment using IL-16 antagonist peptides The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can ... | 03/29/2011 |
| 7903246 | Deterministic aperiodic patterned dielectric and plasmonic materials for localized electromagnetic field enhancement A method is shown for the extension in higher spatial dimensions of deterministic, aperiodic structures which exhibit strong aperiodic effects and have overall compatibility with the planar technology of integrated optical circuits. Disclosed devices are operative i... | 03/08/2011 |
| 7888044 | Melanoma biomarker and methods of uses The present invention relates to the use of TROY, also called tumor necrosis factor receptor superfamily, member 19 (TNFRSF 19) also called toxicity and JNK inducer (TAJ), in diagnosis and therapy of non-epithelial cancers, such as melanoma. Accordingly, the inventi... | 02/15/2011 |
| 7883475 | Manipulators employing multiple deformable elongate members A manipulator is configured with three or more substantially concentric, elongate members configured such that relative rotation and translation of the elongate members adjusts both the spatial position and orientation of the distal end of the manipulator and the sp... | 02/08/2011 |
| 7867770 | Nanostructured substrate for surface enhanced raman scattering The present invention provides a nanostructured substrate for SERS. A substrate of the invention comprises a surface featuring substantially monodisperse-sized metal nanoparticles disposed thereon. Preferably, the substrate surface provides for SERS and spectra ther... | 01/11/2011 |
| 7816544 | Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxych... | 10/19/2010 |
| 7812054 | Lipoxin analogs and methods for the treatment of periodontal disease This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invent... | 10/12/2010 |
| 7807375 | Method for de novo detection of sequences in nucleic acids: target sequencing by fragmentation The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass ... | 10/05/2010 |
| 7806854 | Fully automated control system for type 1 diabetes An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject... | 10/05/2010 |
| 7799539 | Apparatus for detecting and recording cellular responses Cellular physiology workstations for automated data acquisition and perfusion control are described. The cellular physiology workstation may be used for physiological and electrophysiological experiments. Methods for employing such cellular physiology workstations i... | 09/21/2010 |
| 7798000 | Non-destructive imaging, characterization or measurement of thin items using laser-generated lamb waves A laser-based ultrasonic technique for the inspection of thin plates and membranes employs an amplitude-modulated laser source to excite narrow bandwidth Lamb waves. The dominant feature in the acoustic spectrum is a sharp resonance peak that occurs at the minimum f... | 09/21/2010 |
| 7785798 | Methods for prenatal diagnosis of chromosomal abnormalities Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal... | 08/31/2010 |
| 7709451 | Method and composition for treating immune complex associated disorders The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for deve... | 05/04/2010 |
| 7709262 | Method for detecting and quantifying rare mutations/polymorphisms The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic ac... | 05/04/2010 |
| 7700650 | Lipoxin analogs and method for the treatment of periodontal disease This invention provides new lipoxin analogs, compositions containing these analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The ... | 04/20/2010 |
| 7700325 | Haplotype analysis The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel s... | 04/20/2010 |
| 7655399 | Methods for prenatal diagnosis of chromosomal abnormalities Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal... | 02/02/2010 |
| 7652773 | Enhanced detection of acousto-photonic emissions in optically turbid media using a photo-refractive crystal-based detection system A system and method of detecting acousto-photonic emissions in optically turbid media that provide increased levels of detection sensitivity. The detection system includes an ultrasonic transducer, a laser, a photo-detector for detecting ultrasound-modulated laser l... | 01/26/2010 |
| 7649014 | Genipin derivatives and uses thereof Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed. | 01/19/2010 |
| 7626007 | Transcription factor regulating TNF-α Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in the promoter of the human TNF-α gene. Additionally, the level of the ... | 12/01/2009 |
| 7608691 | Antibodies against IL-16 antagonist peptides The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can ... | 10/27/2009 |
| 7595872 | Analyzer for nanostructured substrate for surface enhanced Raman scattering A Raman scattering spectrographic analyzer wherein a microscope objective is adapted to view single bio-specimens on a substrate having monodispersed-sized metal particles. A defined wavelength of radiation is applied through the microscope and returning radiation r... | 09/29/2009 |
| 7588626 | Composite mixed oxide ionic and electronic conductors for hydrogen separation A mixed ionic and electronic conducting membrane includes a two-phase solid state ceramic composite, wherein the first phase comprises an oxygen ion conductor and the second phase comprises an n-type electronically conductive oxide, wherein the electronically conduc... | 09/15/2009 |
| 7579146 | Nucleic acid cloning The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molec... | 08/25/2009 |
| 7569341 | Nucleic acid directed immobilization arrays and methods of assembly The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic acids and a plurality of mediators wherein each mediator comprises a se... | 08/04/2009 |
| 7495998 | Biomimetic acoustic detection and localization system An acoustic detection and localization system includes a signal acquisition stage, a biomimetic processor, and an acoustic feature processor. The system uses multiple acoustic cues including spectral content, inter-aural time delay (ITD), inter-aural intensity diffe... | 02/24/2009 |
| 7479632 | E-beam vision system for monitoring and control A method of characterizing an electron beam is described, comprising providing a system including an electron gun having a steering coil. A material having a surface is also provided. An electron beam from said electron gun is directed to said surface. The directing... | 01/20/2009 |
| 7470517 | Method for detection of sequences in nucleic acids: target sequencing by fragmentation The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass ... | 12/30/2008 |
| 7439021 | Nucleic acid cloning The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molec... | 10/21/2008 |
