Celebrity Inventors
Comic actor Danny Kaye received patent D166,807 for the co-design of "Blowout Toy or the Like". It's similar to one of those toys that unravels when you blow into at a birthday party except Kaye's has three blowouts going in different directions, not just one.
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| Number | Title | Issue Date |
| 6690399 | Data display software for displaying assay results A method and apparatus for displaying data presents results from a single assay across multiple wells and plates on a single screen in a format that preserves the spatial relationship between the wells on a plate and the sequential relationship between pl... | 02/10/2004 |
| 6686171 | Competitive chemiluminescent assay for cyclic nucleotide monophosphates A competitive assay for the concentration of a cyclic nucleotide such as cyclic adenosine monophosphate combines, in a reaction chamber provided with a capture antibody, an antibody for the cAMP or other cyclic nucleotide, the sample to be assayed and a c... | 02/03/2004 |
| 6602657 | Multiple reporter gene assay A method of measuring the activity of at least two reporter gene products in an aliquot of a sample extract is disclosed. The activities of a first and second reporter enzyme are quantified by measuring the light signal produced by degradation of a first ... | 08/05/2003 |
| 6602658 | Multiple reporter gene assay A method of measuring the activity of at least two reporter gene products in an aliquot of a sample extract is disclosed. The activities of a first and second reporter enzyme are quantified by measuring the light signal produced by degradation of a first ... | 08/05/2003 |
| 6586196 | Multiple enzyme assays The present invention discloses multiple enzyme assays which measure the activity of at least one endogenous enzyme in a single aliquot and a method of measuring the activity of multiple enzymes in an aliquot of a cell extract, wherein at least one of the... | 07/01/2003 |
| 6555698 | Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor The present invention discloses chemiluminescent 1,2-dioxetane substrates capable of reacting with a neuraminidase to release optically detectable energy. These 1,2-dioxetanes have the general formula: ##STR1## wherein Z is ##STR2## and the variables... | 04/29/2003 |
| 6518068 | Luminescence detection workstation A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled... | 02/11/2003 |
| 6514717 | Kit for conducting an assay to detect a substance using enzymatically-induced decomposition of dioxetanes A kit for detecting a first substance in a sample including a stabilized 1,2-dioxetane bearing an enzyme-labile substituent, which is destabilized and caused to decompose by contacting the 1,2-dioxetane with an enzyme under conditions which cause the enzy... | 02/04/2003 |
| 6451531 | Dioxetane labeled probes and detection assays employing the same Probes labeled with 1,2-dioxetane precursors can be employed in a variety of assays. The probes may be nucleic acid, peptide nucleic acid, proteins including enzyme, antibody or antigen, steroid, carbohydrate, drug or non-drug hapten. The probe is provide... | 09/17/2002 |
| 6355441 | Benzothiazole dioxetanes Chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature, represented by the formulas I or II: ##STR1##... | 03/12/2002 |
| 6346615 | Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an en... | 02/12/2002 |
| 6322727 | Kit for conducting an assay to detect a substance using enzymatically-induced decomposition of dioxetanes A kit for detecting a first substance in a sample including a stabilized 1,2-dioxetane bearing an enzyme-labile substituent, which is destabilized and caused to decompose by contacting the 1,2-dioxetane with an enzyme under conditions which cause the enzy... | 11/27/2001 |
| 6287767 | Chemiluminescent energy transfer assays A chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhos™ as chemiluminescent substrates for enzyme-labeled targets or probes is provided. Further disclose... | 09/11/2001 |
| 6243980 | Protease inhibitor assay Heterogenous and homogenous assays are provided for the detection of protease inhibitory activity in a sample or target compound, taking advantage of the chemiluminescent characteristics of 1,2-dioxetanes. In the heterogenous assay, a peptide bearing a cl... | 06/12/2001 |
| 6183978 | Luciferase assay, compositions and kits for use in connection therewith An assay for the presence of luciferase in a biological sample offers heightened sensitivity, signal intensity and persistence. The assay is sensitive down to 50 fg luciferase. The biological sample is combined with essential ingredients luciferin, ADP, m... | 02/06/2001 |
| 6162610 | Xanthan-ester and acridan substrates for horseradish peroxidase Xanthan esters and acridans are substrates for horseradish peroxidase. These stable, enzymatically cleavable chemiluminescent esters are substrates for horseradish peroxidase which, together with peroxide is among the extensively used enzyme in enzyme-lin... | 12/19/2000 |
| 6140495 | Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an en... | 10/31/2000 |
| 6133459 | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a c... | 10/17/2000 |
| 6132956 | Chemiluminescent 1,2-dioxetanes Dioxetanes that can be triggered by bases are provided which can be used to detect bases in organic solvents, aqueous preparations and detect gaseous bases in the atmosphere. The dioxetanes can be used to detect the release of bases from various labels, a... | 10/17/2000 |
| 6124478 | Methods of using 1,2-dioxetanes and kits therefore Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a comp... | 09/26/2000 |
| 6113816 | Kit for conducting an assay to detect a substance using enzymatically-induced decomposition of dioxetanes A kit for detecting a first substance in a sample comprising a dioxetane having the formula: ##STR1## wherein T is a cycloalkyl or polycycloalkyl group bonded to the 4-membered ring portion of the dioxetane by a spiro linkage; Y is a fluorescent ... | 09/05/2000 |
| 6107024 | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a c... | 08/22/2000 |
| 6063574 | Dioxetane labeled probes and detection assays employing the same Probes labeled with 1,2-dioxetane precursors can be employed in a variety of assays. The probes may be nucleic acid, peptide nucleic acid, proteins including enzyme, antibody or antigen, steroid, carbohydrate, drug or non-drug hapten. The probe is provide... | 05/16/2000 |
| 6022964 | Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an en... | 02/08/2000 |
| 5994073 | Enhancement of chemiluminescent assays Chemiluminescent bioassays for the presence or concentration of an analyte in a sample use 1,2-dioxetanes as substrates for the enzyme of an enzyme complex that bind to the analyte. The chemiluminescence obtained from the decomposition of the dioxetane tr... | 11/30/1999 |
| 5981768 | 1,2 chemiluminescent dioxetanes of improved performance A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stab... | 11/09/1999 |
| 5891626 | Method providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a c... | 04/06/1999 |
| 5871938 | Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore 1,2-dioxetane compounds bearing a proteolytic enzyme specific amino acid or peptide are provided, which amino acid or peptide can be removed by action of the corresponding protease. When the amino acid or peptide is removed, the 1,2-dioxetane decomposes w... | 02/16/1999 |
| 5869705 | Enzyme-activated 1,2-dioxetanes In an assay method in which a member of a specific binding pair is detected by means of an optically detectable reaction, the improvement wherein the optically detectable reaction includes the reaction, with an enzyme, of a dioxetane having the formula ... | 02/09/1999 |
| 5869699 | 1,2 chemiluminescent dioxetanes of improved performance A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stab... | 02/09/1999 |
| 5866389 | Kit for conducting an assay to detect a substance using enzymatically-induced decomposition of dioxetanes A kit including a dioxetane and an enzyme reactive therewith is useful in an assay method in which a member of a specific binding pair is detected by means of an optically detectable reaction, the improvement wherein the optically detectable reaction incl... | 02/02/1999 |
| 5856522 | Method of using synthesis of 1,2-dioxetanes and kits therefore Kits comprising 1,2-dioxetanes which can be cause to chemiluminesce by contact with an enzyme, and the enzyme, are provided for use in optically detectable assays. The assay calls for binding the enzyme to the substance to be detected in a sample, removin... | 01/05/1999 |
| 5851771 | Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an en... | 12/22/1998 |
| 5849495 | Chemiluminescent energy transfer assays A chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhos™ as chemiluminescent substrates for enzyme-labeled targets or probes is provided. Further disclose... | 12/15/1998 |
| 5847161 | 1, 2 chemiluminescent dioxetanes of improved performance A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stab... | 12/08/1998 |
| 5843681 | Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore 1, 2-dioxetane compounds bearing a proteolytic enzyme specific amino acid or peptide are provided, which amino acid or peptide can be removed by action of the corresponding protease. When the amino acid or peptide is removed, the 1,2-dioxetane decomposes ... | 12/01/1998 |
| 5840919 | Chemiluminescent 1,2-dioxetanes Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T1/2, etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or arylalkoxy substituen... | 11/24/1998 |
| 5831102 | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile substituent thereof is intentionally clea... | 11/03/1998 |
| 5827650 | Membrane for chemiluminescent blotting applications A new and improved polymeric membrane for use in biological assays is provided. A blotting assay employing 1,2-dioxetanes as a source of chemiluminescent employs, as an improved membrane, a polymer comprised of at least one monomer of the formula: ##... | 10/27/1998 |
| 5800999 | Dioxetane-precursor-labeled probes and detection assays employing the same Probes labeled with 1,2-dioxetane precursors can be employed in a variety of assays. The probes may be nucleic acid, peptide nucleic acid, proteins including enzyme, antibody or antigen, steroid, carbohydrate, drug or non-drug hapten. The probe is provide... | 09/01/1998 |
