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Assignee: Trillium Therapeutics Inc.


Location: Toronto, CA
No. of patents: 8

NumberTitleIssue Date
7332631Fc receptor modulating compounds and compositions
The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method...
02/19/2008
7196243Transgenic animal containing CD200 and uses therefor
The present invention is directed toward a transgenic non-human animal and uses thereof, wherein each of the cells of the animal contain a transgene comprising a nucleic acid sequence encoding CD200. ...
03/27/2007
6984625Methods and compositions for modulating autoimmunity
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune ...
01/10/2006
6955811Methods of inhibiting immune response suppression by administering antibodies to OX-2
Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an...
10/18/2005
6805863Methods of modulating immune coagulation
Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful in preventing and treating diseases which require a reduction in immu...
10/19/2004
6749854Use of OX-2 to inhibit fetal loss
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune ...
06/15/2004
6652858Use of OX-2 to suppress an immune response
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, ...
11/25/2003
6642433Fgl-2 knockout mice
A knockout mouse in which the Fgl-2 gene has been suppressed is described. The mouse is useful in studying the role of Fgl-2 in normal and disease states including viral hepatitis, allograph rejection, fetal loss, inflammatory bowel disease, lupus glomeru...
11/04/2003
 
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