Today In History
James McLean is issued a patent for a piano.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7695960 | Composition comprising the polyprotein NS3/NS4 and the polypeptide NS5B of HCV, expression vectors including the corresponding nucleic sequences and their therapeutic use The invention relates to a peptidic compound containing a polyprotein NS3/NS4 of a hepatitis C virus and a polypeptide NS5b of hepatitis C virus. Said invention also relates to expression vectors such as adenovirus and poxyvirus in which nucleic sequences coding for... | 04/13/2010 |
| 7670607 | Pharmaceutical compositions for treating papillomavirus tumors and infection A pharmaceutical composition for treating or preventing a papillomavirus infection or tumor, including, as the therapeutical agents, a polypeptide from an early region and a polypeptide from a late region of a papillomavirus, optionally combined with a polypeptide h... | 03/02/2010 |
| 7608267 | Multifunctional cytokines The present invention relates to a novel fusion protein with the formula X—Y, or Y—X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating polypeptide different from X; it also relates to a nucleic acid molecule en... | 10/27/2009 |
| 7572438 | Mutant having uracil phosphoribosyl transferase activity The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a vi... | 08/11/2009 |
| 7560527 | Modified adenovirus fibre and uses The invention concerns an adenovirus fiber modified by mutation of one or several residues of the region included between residues 491 and 505 of SEQ ID NO: 1, the viral particles or pseudo-particles comprising such a fiber and their uses. ... | 07/14/2009 |
| 7534585 | Multifunctional cytokines The present invention relates to a novel fusion protein with the formula X—Y, or Y—X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating polypeptide different from X. The present invention also relates to a nucle... | 05/19/2009 |
| 7488482 | Pharmaceutical compositions for treating papillomavirus tumors and infection A pharmaceutical composition for treating or preventing a papillomavirus infection or tumour, including, as the therapeutical agents, a polypeptide from an early region and a polypeptide from a late region of a papillomavirus, optionally combined-with a polypeptide ... | 02/10/2009 |
| 7482155 | Chimeric promoters for controlling expression in smooth muscle cells The present invention concerns a chimeric construct comprising a SMC-specific promoter operably linked to a muscle-specific enhancer. It also provides an expression cassette comprising such a chimeric construct to control expression of a therapeutic gene. Finally, t... | 01/27/2009 |
| 7378265 | Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of between −5° C. and +50° C. and at a pH of between about 5 and 9. Its ... | 05/27/2008 |
| 7354591 | Poxvirus with targeted infection specificity The present invention concerns a poxviral particle having a targeted infection specificity conferred by an heterologous ligand moiety present at the surface of said poxviral particle and capable of specifically recognizing and binding to an anti-ligand molecule loca... | 04/08/2008 |
| 7348014 | Poxvirus with targeted infection specificity The present invention concerns a poxviral particle having a targeted infection specificity conferred by an heterologous ligand moiety present at the surface of said poxviral particle and capable of specifically recognizing and binding to an anti-ligand molecule loca... | 03/25/2008 |
| 7264958 | Method for obtaining a purified viral preparation The invention concerns a method for purifying a crude viral preparation containing viral, in particular adenoviral, particles of interest. The invention is characterised in that it comprises a step of adsorption on a fluidised bed. The invention also concerns a prot... | 09/04/2007 |
| 7118754 | Pharmaceutical composition for treating papillomavirus tumors and infection A pharmaceutical composition for treating or preventing a papillomavirus infection or tumour, including, as the therapeutical agents, a polypeptide from an early region and a polypeptide from a late region of a papillomavirus, optionally combined with a polypeptide ... | 10/10/2006 |
| 7067310 | Method for the preparation of a viral vector by inter-molecular homologous recombination The present invention encompasses methods of preparing a recombinant viral vector, within a procaryotic cell, by intermolecular homologous recombination, methods of preparing an infectious viral particle containing the recombinant viral vector and pharmaceutical com... | 06/27/2006 |
| 7067309 | Defective adenoviruses and corresponding complementation lines Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the process for the preparation of these novel defective adenoviruses and th... | 06/27/2006 |
| 7049117 | Mutant possessing uracil phosphoribosyl transferase activity The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a vi... | 05/23/2006 |
| 7033779 | Method for preparing steroids modified by yeast fermentation The invention concerns a novel method for producing hydroxylated and/or acetylated steroid comprising steps which consist in: culturing yeasts on a medium comprising at least a precursor of such hydroxylated and/or acetylated steroids; then isolating the hydroxylate... | 04/25/2006 |
| 7026299 | Connective tissue growth factor-2 The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provide... | 04/11/2006 |
| 7026154 | Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of between −5° C. and +50° C. and at a pH of between about 5 and 9. Its ... | 04/11/2006 |
| 7005277 | Defective adenoviruses and corresponding complementation lines Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the process for the preparation of these novel defective adenoviruses and th... | 02/28/2006 |
| 6960469 | Adenoviral vectors encoding an antibody fused to a CD4 extracellular domain Genetically modified cell implant comprising an exogenous nucleotide sequence coding for all or part of an antibody, method for the preparation of such an implant and its therapeutic use for the treatment or prevention of an acquired disease. The invention also conc... | 11/01/2005 |
| 6906041 | Treatment of immune diseases The invention concerns the use of a nucleic acid capable of expressing beta-interferon for the preparation of a pharmaceutical composition for the treatment of an immune disease. ... | 06/14/2005 |
| 6884786 | Antitumoral composition based on immunogenic polypeptide with modified cell location Antitumoral compositions can comprise as therapeutic agent one or several immunogenic polypeptides, of which at least one is modified so as to have a cell location different from its native location. Compositions can be based on a recombinant vector expressing such ... | 04/26/2005 |
| 6881724 | Use of magnesium (Mg2+) for the preparation of a therapeutic composition for transfection of a polynucleotide into a cell and compositions useful in gene therapy Described is the use of magnesium (Mg2+) for the preparation of a therapeutic composition for the introduction of a polynucleotide into a cell in vivo. ... | 04/19/2005 |
| 6743781 | Glycerolipid compounds useful for the transfer of an active substance into a target cell The invention concerns novel compounds of formula (I) in which: R1 and R2, which are identical or different, are C6-C23 alkyl or alkenyl radicals, linear or branched or —C(â•... | 06/01/2004 |
| 6740511 | Modified adenoviral fibre and uses thereof The present invention relates to a modified fiber of an adenovirus, comprising at least one mutation at one or more residues within the region of said fiber stretching from pleated sheet A to pleated sheet B, and including loop AB. ... | 05/25/2004 |
| 6723708 | Use of lithium (Li+) for the preparation of a composition for transfection of a polynucleotide into a cell and compositions useful in gene therapy Described is the use of lithium (Li+) for the preparation of a therapeutic composition for the introduction of a polynucleotide into a cell. ... | 04/20/2004 |
| 6703226 | Expression of a foamy virus envelope protein The invention concerns constructs for the expression of a protein comprising at least a modified FV envelope protein, the protein so obtained as well as the complementation cell line permitting the production of pseudotyped viral particle. It also concern... | 03/09/2004 |
| 6692956 | Recombinant adenoviral vectors The present invention concerns a recombinant adenoviral vector derived from an adenovirus genome in which at least a part of the E3 region is deleted or is non functional, wherein said adenoviral vector retains E3 sequences encoding a functional 14.7K pro... | 02/17/2004 |
| 6656734 | Compositions for the delivery of polynucleotides to cells The present invention relates to a composition which is intended for transferring at least one therapeutically active substance into the interior of a target cell, characterized in that it comprises a mixture of at least one therapeutically active substan... | 12/02/2003 |
| 6596533 | Mutant having uracil phosphoribosyl transferase activity The focus of the present invention is a polypeptide having a uracil phosphoribosyl transferase (UPRTase) activity achieved by mutation of one or more residues of the UPRTase. The invention also relates to a nucleotide sequence coding for the UPRTase mutan... | 07/22/2003 |
| 6582694 | Method for preparing a viral aerosol A method for preparing a viral aerosol from a dilute viral suspension prepared by dissolving a virus in an aqueous solution containing 6-12 g/l of a monovalent cation salt, or 50-100 g/l of a hexose, which is then nebulized with a gas pressure of 0.5-3.5 ... | 06/24/2003 |
| 6569677 | Modified adenoviral fiber and target adenoviruses The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragme... | 05/27/2003 |
| 6555377 | Process for production of mammalian cell lines Described is a process for generating a mammalian cell line from primary mammalian cells, comprising the step of: a) pre-treating a culture of said primary mammalian cells or a suspension thereof with at least one glucocorticoid, b) optional step comprising ob... | 04/29/2003 |
| 6528312 | Use of G-actin for improving transfection of a polynucleotide into a cell Described is the use of a nuclease inhibitor or of interleukin-10 (IL-10) for the preparation of a therapeutic composition for improving transfection of a polynucleotide into a cell, and to compositions comprising a mixture of polynucleotide and nuclease ... | 03/04/2003 |
| 6514756 | Human myoblast cell lines and their uses Described is a human muscular cell line which is able to proliferate and generated from primary human muscular cells by a process comprising the step of: a) pre-treating a culture of said primary human muscular cells or a suspension thereof with at least ... | 02/04/2003 |
| 6479290 | Chimeric adenoviral vectors The invention concerns adenoviral vectors having the characteristic of containing a region essential for heterologous packaging with respect to the adenoviral genome from which they are derived. The invention also concern a method for making a viral prepa... | 11/12/2002 |
| 6475480 | Use of adenoviral E4 reading frames to improve expression of a gene of interest Described are recombinant adenoviral vectors retaining sufficient E4 sequences to improve the expression and/or persistence of expression of a gene of interest. Furthermore, the invention describes the use of a polynucleotide encoding one or more ORF(s) o... | 11/05/2002 |
| 6451256 | Method for preserving infectious recombinant viruses, aqueous viral suspension and use as medicine The present invention provides a novel method for preserving infectious recombinant viruses in frozen or liquid form, in which infectious viruses are preserved in an aqueous solution. The recombinant virus suspension comprises an aqueous sucrose solution ... | 09/17/2002 |
| 6407178 | Cationic polymers, complexes associating said cationic polymers with therapeutically active substances comprising at least a negative charge, in particular nucleic acids, and their use in gene therapy The invention concerns novel cationic polymers of formula (I) in which n is a whole number between 0 and 5 and p is a whole number between 2 and 20,000, more particularly p ranges between 10 and 18,000, and advantageously between 200 and 1,000, characteri... | 06/18/2002 |
