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| Number | Title | Issue Date |
| 6204383 | Processes for preparing sildenafil Sildenafil, a known pharmaceutical chemical useful in treatment of male sexual dysfunction, is prepared by processes in which the final chemical intermediate is of significantly lower basicity than sildenafil itself, so that sildenafil can be extracted in... | 03/20/2001 |
| 6048981 | Magnesium omeprazole and process for its preparation Magnesium omeprazole is provided, in a form free of organic solvent residues and free of traces of more than 50 ppm of another metal ion. It is prepared by an aqueous phase process in which a solution of omeprazole in concentrated aqueous ammonia is added... | 04/11/2000 |
| 5981757 | Nizatidine preparation Nizatidine is prepared by reacting N-[2-[[[2-(hydroxymethyl)-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro -1,1-ethenediamine, with an aryl- or tert.alkyl-sulfonyl halide in the presence of a tertiary amine base and a sulfonation catalyst to form the ... | 11/09/1999 |
| 5783702 | Preparation of cisapride Cisapride, i.e. cis-4-amino-5-chloro-N-1-3-(4 fluoro-phenoxy)propyl!-3-methoxy-4-piperidinyl!-2-methoxy-benzamide, and similar benzamide derivatives, are prepared from novel 1-aryloxyalkyl- or 1-aralkyl-3-arylcarbonyloxy-4-oxo-piperidines, by nuclear ... | 07/21/1998 |
| 5734083 | Sertraline polymorph A novel polymorph of sertraline hydrochloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenam ine hydrochloride, is disclosed, having improved water solubility along with acceptable stability. It is characterized by a uniqu... | 03/31/1998 |
| 5700945 | Process for preparing nizatidine Nizatidine is prepared by a process in which the final step is the reaction of the 2-hydroxymethyl analog of nizatidine, namely N-2-2-(hydroxymethyl)-4-thiazolidyl!-methyl!thio!ethyl!-N'-methyl-2-ni tro-1,1-ethenediamine, with excess dimethylamine ... | 12/23/1997 |
| 5684177 | Misoprostol In a process for making synthetic prostaglandin-type compounds such as misoprostol, organo metallic cuprate complexes capable of reacting with cyclopentenones are prepared by reaction of an alkyl lithium compound with a cuprous halide, followed by reactio... | 11/04/1997 |
| 5665884 | Preparation of cisapride Cisapride, i.e. cis-4-amino-5-chloro-N-[1-[3-(4 fluoro-phenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-benzamide, and similar benzamide derivatives, are prepared from novel 1-aryloxyalkyl- or 1-aralkyl-3-arylcarbonyloxy-4-oxo-piperidines, by nuclear su... | 09/09/1997 |
| 5585387 | Prepration of cisapride Cisapride, i.e. cis-4-amino-5-chloro-N-[1-[3-(4 fluoro-phenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-benzamide, and similar benzamide derivatives, are prepared from novel 1-aryloxyalkyl- or 1-aralkyl-3-arylcarbonyloxy-4-oxo-piperidines, by nuclear su... | 12/17/1996 |
| 5541335 | Process for preparing nizatidine Nizatidine is prepared by a process in which the final step is the reaction of the 2-hydroxymethyl analog of nizatidine, namely N-[2-[[[2-(hydroxymethyl)-4-thiazolidyl]-methyl]thio]ethyl]-N'-methyl-2-ni tro-1,1-ethenediamine, with excess dimethylamine and ... | 07/30/1996 |
| 5470983 | Preparation of omeprazole and lansoprazole, and intermediates useful therein Omeprazole and lansoprazole, which are chemically pyridine-benzimidazole sulfinyl compounds, are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound, followed by alkaline hydrolysis to ... | 11/28/1995 |
| 5374730 | Preparation of omeprazole and lansoprazole Omeprazole and lansoprazole, which are chemically pyridine-benzimidazole sulfinyl compounds, are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound, followed by alkaline hydrolysis to ... | 12/20/1994 |
| 5371240 | Process for the preparation of pure thiophene derivatives 3-substituted thiophene compounds contaminating the analogous 2-substituted thiophene compounds, e.g. 3-acetylthiophene contaminating 2-acetyl thiophene, are removed by a selective electrophilic substitution process, e.g. bromination, followed by fraction... | 12/06/1994 |
| 5338871 | Preparation of form 1 ranitidine hydrochloride Pure Form 1 ranitidine hydrochloride is prepared by a process of crystallization from a solution of ranitidine hydrochloride in a mixed solvent comprising 1 part by volume of at least one lower alkanol such as ethanol and 1-2.0 parts by volume of a C... | 08/16/1994 |
| 4808741 | Process for preparing carboxyalkyl dipeptides Pharmaceutically active carboxyalkyl dipeptides such as enalapril, lisinopril and the like, are prepared from a starting amino acid such as L-alanine, by protecting the acid function of the amino acid with an alkyl silyl protecting group, while it is reac... | 02/28/1989 |
| 4760182 | Process for preparing substituted phenol ethers via oxazolidine-structure intermediates Phenol ethers such as 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-prop anol, otherwise known as betaxolol, of formula: ##STR1## are prepared from p-hydroxyphenethyl alcohol by first reacting at the phenolic group, with e... | 07/26/1988 |
