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| Number | Title | Issue Date |
| 7463983 | TOF with clock phase to time bin distribution A TOF mass spectrometer has a clock phase to time bin cycling device that distributes data among storage cells in a random or systematic pattern that cancels out errors due to binary clock path and/or binary signal line irregularities. Data for peaks acquired from p... | 12/09/2008 |
| 7459678 | Switchable branched ion guide A switchable branched ion guide is disclosed. The switchable branched ion guide includes a trunk section, first and second branch sections, a junction connecting the trunk section to the branch sections, and a movable valve member located at the junction. The valve ... | 12/02/2008 |
| 7459676 | MALDI/LDI source A MALDI/LDI source includes an ion collection device, e.g., a skimmer, orifice, mass analyzer, ion transfer optics and/or ion guide, configured for use with a short focal length lens with a large aperture. In some embodiments, the ion collection device includes an o... | 12/02/2008 |
| 7456398 | Efficient detection for ion traps An apparatus and method are disclosed for efficient detection of ions ejected from a quadrupolar ion trap, in which the ions are ejected as first and second groups of ions having different directions. The first and second groups of ions are received by a conversion ... | 11/25/2008 |
| 7456396 | Isolating ions in quadrupole ion traps for mass spectrometry Ions in a predefined narrow mass to charge ratio range are isolated in an ion trap by adjusting the field and using ejection frequency waveform(s). Thus the mass-to-charge ratio isolation window is controlled and has an improved resolution without increasing the num... | 11/25/2008 |
| 7456389 | High throughput quadrupolar ion trap A method and apparatus are provided for operating a linear ion trap. A linear ion trap configuration is provided that allows for increased versatility in functions compared to a conventional three-sectioned linear ion trap. In operation, the linear ion trap provides... | 11/25/2008 |
| 7446310 | High throughput quadrupolar ion trap A method and apparatus are provided for operating a linear ion trap. A linear ion trap configuration is provided that allows for increased versatility in functions compared to a conventional three-sectioned linear ion trap. In operation, the linear ion trap provides... | 11/04/2008 |
| 7440095 | Spectroscope with vignetting reduction In a spectrometer, preferably in a spectrometric microscope, input light is provided from a light source to a specimen via a source objective element (e.g., a Schwarzchild objective), and the aperture of the light source is matched to the aperture of the source obje... | 10/21/2008 |
| 7425699 | Mass spectrometry method and apparatus A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and pas... | 09/16/2008 |
| 7420161 | Branched radio frequency multipole Systems and methods of the invention include a branched radio frequency multipole configured to act, for example, as an ion guide. The branched radio frequency multipole comprises multiple ion channels through which ions can be alternatively directed. The branched r... | 09/02/2008 |
| 7417225 | Apparatus and method for adjustment of ion separation resolution in FAIMS An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is provided for extracting a subset of the ions that is selectively transmitt... | 08/26/2008 |
| 7399962 | All-mass MS/MS method and apparatus A method of obtaining a mass spectrum of elements in a sample is disclosed. Sample precursor ions having a mass to charge ratio M/Z are generated, and fragmented at a dissociation site, so as to produce fragment ions of mass to charge ratio m/z. The fragment ions ar... | 07/15/2008 |
| 7391019 | Electrospray ion source An on-axis ion source has an ionization chamber and an adjacent low-pressure region. The on-axis ion source also includes a capillary tube having an axial bore for supporting fluid communication between the ionization chamber and the adjacent low-pressure region, th... | 06/24/2008 |
| 7385193 | System and method for implementing balanced RF fields in an ion trap device A system and method are disclosed for effectively compensating for non-linear field components created by a field distortion feature in a quadrupolar ion trap, compensation provided by a geometric surface shaping which reduces the non-linear field components and cre... | 06/10/2008 |
| 7381947 | Electrode networks for parallel ion traps An electrode network for N parallel ion traps, wherein N is an integer larger than 1, includes at most 2N+2 electrodes, which form N trapping volumes each corresponding to a respective one of the N parallel ion traps. Also provided is a parallel mass spectrometer, c... | 06/03/2008 |
| 7378651 | High field asymmetric waveform ion mobility spectrometer FAIMS Disclosed is an apparatus for separating ions including a plurality of first electrode portions, each first electrode portion of the plurality of first electrode portions having a first length and an outer surface that is at least partially curved in a direction tra... | 05/27/2008 |
| 7368709 | Low field mobility separation of ions using segmented cylindrical FAIMS A method of separating ions is disclosed. The method includes a step of providing a FAIMS analyzer region for separating ions, the FAIMS analyzer region including at least one region of segmentation. The segmentation permits ion trapping, and a combination trapping ... | 05/06/2008 |
| 7365318 | System and method for implementing balanced RF fields in an ion trap device A system and method are disclosed for effectively compensating for an unbalanced or non-zero centerline radio-frequency potential in a quadrupolar ion trap, the unbalanced centerline potential created by a compensation feature that minimizes non-linear field compone... | 04/29/2008 |
| 7358504 | FAIMS apparatus and method for separating ions Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) for separating ions, and a method therefore. The FAIMS includes an electrode stack (24) having a length and comprising a plurality of electrodes (26, 28). Each electrode of the electrode... | 04/15/2008 |
| 7351961 | Measuring cell for ion cyclotron resonance spectrometer This invention relates to a measuring cell for an Ion Cyclotron Resonance (ICR) spectrometer. The present invention provides a measurement cell for an FTMS spectrometer, comprising an excitation electrode arrangement positioned about a longitudinal axis which extend... | 04/01/2008 |
| 7351955 | Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of a linear ion trap in which analyte ions and matrix cluster ions are c... | 04/01/2008 |
| 7351960 | Enhanced ion desolvation for an ion mobility spectrometry device An ion spectrometer apparatus is disclosed having an ion source, an ion mobility spectrometer device such as a FAIMS cell, and a capillary for transporting ions from the ion source to the entrance of the FAIMS cell. The capillary is heated to promote evaporation of ... | 04/01/2008 |
| 7342224 | Obtaining tandem mass spectrometry data for multiple parent ions in an ion population This invention relates to tandem mass spectrometry and, in particular, to tandem mass spectrometry using a linear ion trap and a time of flight detector to collect mass spectra to form a MS/MS experiment. The accepted standard is to store and mass analyze precursor ... | 03/11/2008 |
| 7338249 | Sample plate gripping mechanism An apparatus for releasably gripping a sample plate for use with a mass spectrometer has been developed, the sample plate having substantially parallel faces and a peripheral surface. The apparatus comprises a planar member and first and second guiding structures. T... | 03/04/2008 |
| 7323682 | Pulsed ion source for quadrupole mass spectrometer and method A variable duty cycle ion source assembly is coupled to a continuous beam mass spectrometer. The duty cycle can be adjusted based on previous scan data or real time sampling of ion intensities during mass analysis. This provides the ability to control the total numb... | 01/29/2008 |
| 7312441 | Method and apparatus for controlling the ion population in a mass spectrometer A method of controlling the population of ions in a mass spectrometer in which a first sample of ions is provided in the mass spectrometer, a measure of abundance of a species of interest in the first sample of ions is determined, the measure of abundance comprising... | 12/25/2007 |
| 7297941 | Methods for improved data dependent acquisition A method of analyzing data from a mass spectrometer for a data dependent acquisition is described. In an embodiment of this method, mass spectral scans are taken of a sample eluted from a liquid chromatography column. An extracted ion chromatogram (XIC) is then crea... | 11/20/2007 |
| 7285774 | FAIMS apparatus and method for separating ions in the gas phase Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) including a set of spaced-apart parallel rods, the space between the parallel rods having first and second ends and defining an analyzer region. The apparatus includes an electrical cont... | 10/23/2007 |
| 7282707 | Method and apparatus for handling a sample plate for use in mass analysis A new sample plate handling apparatus for use with mass analysis, and methods for use the same have been developed. The sampling plate handling apparatus comprises a sample plate receiver which receives the sample plate in a first plane, a rotating device for rotati... | 10/16/2007 |
| 7274014 | Apparatus and method for adjustment of ion separation resolution in FAIMS An apparatus for controllably varying specificity of a FAIMS-based ion separation includes a FAIMS analyzer region defined between a first electrode surface and a second other electrode surface. The FAIMS analyzer region is in communication with an ionization source... | 09/25/2007 |
| 7265347 | Multiple nano-spray delivery system for FAIMS An apparatus for multiple nano-spray delivery of a sample to FAIMS analyzer includes a micro-machined ionization source having a plurality of discrete nozzles. At least some of the discrete nozzles of the plurality are aligned one each with an ion inlet of a plurali... | 09/04/2007 |
| 7265344 | Mass spectrometry method and apparatus A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and pas... | 09/04/2007 |
| 7250306 | Method for distinguishing between protein variants Disclosed is a method for distinguishing between protein variants using high field asymmetric waveform ion mobility spectrometry (FAIMS). A method according to the instant invention includes the steps of providing a FAIMS analyzer region defined by a space between t... | 07/31/2007 |
| 7238936 | Detector with increased dynamic range A detector assembly has a current measuring device with a saturation threshold level, and a gain variation means. A signal is generated in response to the particles detected, a first data point corresponding to a peak of interest is acquired from the signal. If the ... | 07/03/2007 |
| 7227132 | Apparatus and method for adjustment of ion separation resolution in FAIMS An apparatus for controllably varying specificity of a FAIMS-based ion separation includes a first electrode surface portion defining an ion inlet within a portion thereof and a second electrode surface portion defining an ion outlet within a portion thereof. The se... | 06/05/2007 |
| 7225096 | Method of controlling and correcting an asymmetric waveform Disclosed is a method of controlling an asymmetric waveform generated as a combination of two sinusoidal waves having a frequency that differs by a factor of two. A method according to the instant invention includes a step of sampling a generated asymmetric waveform... | 05/29/2007 |
| 7223971 | Method and apparatus for selecting inlets of a multiple inlet FAIMS An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer... | 05/29/2007 |
| 7223967 | Side-to-side FAIMS apparatus having an analyzer region with non-uniform spacing and method therefore Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) having a side-to-side electrode geometry. The FAIMS includes an inner electrode (102) having a length and an outer surface that is curved in a direction transverse to the length. ... | 05/29/2007 |
| 7217921 | Method and apparatus for FAIMS for in-line analysis of multiple samples A method of separating ions includes providing a FAIMS analyzer region including an ion inlet orifice for providing ions thereto, and providing a sample holder along a side of the ion inlet orifice that is opposite the FAIMS analyzer. A sample material is applied to... | 05/15/2007 |
| 7211794 | Mass spectrometer An improved FT-ICR Mass Spectrometer has an ion source 10 which generates ions that are transmitted through a series of multipoles 20 to an ion trap 30. Ions are ejected from the trap 30, through a series of lens and multipolar ion guide ... | 05/01/2007 |
