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Assignee: TherOx, Inc.


Location: Irvine, CA
No. of patents: 44

1    
NumberTitleIssue Date
7820102Disposable cartridge for producing gas-enriched fluids
A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid u...
10/26/2010
7641628System and method for high pressure delivery of gas-supersaturated fluids
A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a fluid to be ga...
01/05/2010
7468191Method of preparing gas delivering perfluorocarbon emulsions with non-fluorinated surfactants
The present invention provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and ...
12/23/2008
7357937Perfluorocarbon emulsions with non-fluorinated surfactants
A stable FC emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsif...
04/15/2008
7294278Method for oxygenating wastewater
A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo...
11/13/2007
7198179System for storing and dispensing a gas-solubilized product
A packaged gas-solubilized product is described. The gas-solubilized product contains a first gas with a first pressure. The product is placed into a flexible inner container made of a gas-impermeable material. The inner container is hermetically disposed inside an ...
04/03/2007
7172727Apparatus for blood oxygenation
An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary ass...
02/06/2007
7104289System and method for high pressure delivery of gas-supersaturated fluids
A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a fluid to be ga...
09/12/2006
7013703System and method of evaluating or calibrating a bubble detector
A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time ex...
03/21/2006
7008535Apparatus for oxygenating wastewater
A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo...
03/07/2006
6936221Method of forming gas-enriched fluid
A method for forming a gas-enriched fluid is provided. The method includes a step of providing a mixing chamber having a first inlet, a second inlet, and an outlet. A first fluid is delivered into the mixing chamber via the first inlet and flows vertically. A second...
08/30/2005
6899847Apparatus for blood oxygenation
A device for producing a gas-supersaturated fluid is provided. The device includes a chamber having a first inlet to receive a gas and a second and a third inlets to receive a fluid; and an outlet for removal of the produced gas-supersaturated fluid. The gas is rece...
05/31/2005
6890482Apparatus for blood oxygenation
An apparatus and method for blood oxygenation are provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly. The liquid-to-liquid oxygenation assembly includes a pressurizable chamber having inlets for a first gas-supersaturated fluid ...
05/10/2005
6855291Method of blood oxygenation
An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet couple...
02/15/2005
6849235Method of forming gas-enriched fluid
A method for gas-supersaturating fluids, e.g., physiologic saline, includes providing a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined ...
02/01/2005
6843099Bubble detector and method of evaluation or calibration thereof
A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time ex...
01/18/2005
D497989Cartridge for generating gas-enriched fluids
11/02/2004
6811750Apparatus for blood oxygenation
Apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assemb...
11/02/2004
6759008Apparatus and method for blood oxygenation
An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets ...
07/06/2004
6676900Method for the preparation and delivery of gas-enriched fluids
A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the pati...
01/13/2004
6622542Bubble detector and method of use thereof
A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period...
09/23/2003
6613280Disposable cartridge for producing gas-enriched fluids
A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiolo...
09/02/2003
6607698Method for generalized extracorporeal support
A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood ...
08/19/2003
6605217Apparatus for high pressure fluid filtration
A bacterial fluid filter includes a filter element supported by a backing member. The filter element and backing member are sealed, e.g., with one or more o-ring seals, in a housing to provide a filter assembly capable of filtering fluid under relatively ...
08/12/2003
6602467Apparatus and method for blood oxygenation
An apparatus and method for blood oxygenation are provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly. The liquid-to-liquid oxygenation assembly includes a pressurizable chamber having inlets for a first gas-supersatur...
08/05/2003
6602468Method of blood oxygenation
A method for a bubble-free oxygenated blood delivery is provided. The method includes a step of selecting a delivery system having a tubular elongated member with a lumen. The selecting step comprises determining an effective diameter of the lumen needed ...
08/05/2003
6596235Method for blood oxygenation
An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiol...
07/22/2003
6582387System for enriching a bodily fluid with a gas
A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an...
06/24/2003
6576191Apparatus for blood oxygenation
A device for producing a gas-supersaturated fluid is provided. The device includes a chamber having a first inlet to receive a gas and a second and a third inlets to receive a fluid; and an outlet for removal of the produced gas-supersaturated fluid. The ...
06/10/2003
6565807Method of blood oxygenation
An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an ou...
05/20/2003
6558502Method for forming atraumatic fluid delivery device
The present invention is a device for insertion into a human or animal body, in a preferred embodiment a perfusion guidewire capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated wi...
05/06/2003
6555059Method of forming gas-enriched fluid
A method for gas-supersaturating fluids, e.g., physiologic saline, includes providing a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a pre...
04/29/2003
6533766Coating medical device surfaces for delivering gas-supersaturated fluids
A method is provided of using biocompatible surface-active agents to impart improved characteristics to a surface contacting a gas-supersaturated fluid, advantageously by forming on the surface a coating including an adsorbed biocompatible surface-active ...
03/18/2003
6454997Apparatus for the preparation and delivery of gas-enriched fluids
A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the pati...
09/24/2002
6387324Apparatus and method for blood oxygenation
An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiol...
05/14/2002
6346192Apparatus for high pressure fluid filtration
A bacterial fluid filter includes a filter element supported by a backing member. The filter element and backing member are sealed, e.g., with one or more o-ring seals, in a housing to provide a filter assembly capable of filtering fluid under relatively ...
02/12/2002
6315754System and method for high pressure delivery of gas-supersaturated fluids
A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a flu...
11/13/2001
6235007Atraumatic fluid delivery devices
The present invention is a device for insertion into a human or animal body, in a preferred embodiment a perfusion guidewire capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated wi...
05/22/2001
6180059Method for the preparation and delivery of gas-enriched fluids
A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the pati...
01/30/2001
6142971System and method for high pressure delivery of gas-supersaturated fluids
A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a flu...
11/07/2000
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