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Assignee: The trustees of Columbia University in the city of New York


Location: New York, NY
No. of patents: 178

1          
NumberTitleIssue Date
8182786Nano-sized particles, processes of making, compositions and uses thereof
The present invention describes methods for preparing high quality nanoparticles, i.e., metal oxide based nanoparticles of uniform size and monodispersity. The nanoparticles advantageously comprise organic alkyl chain capping groups and are stable in air and in nonp...
05/22/2012
8176418System and method for document collection, grouping and summarization
A system for generating a summary of a plurality of documents and presenting the summary information to a user is provided which includes a computer readable document collection containing a plurality of related documents stored in electronic form. Documents can be ...
05/08/2012
8173347Micropatterning of molecular surfaces via selective irradiation
A method for surface micropatterning includes forming on a surface containing a first polymer a first coating containing a second polymer having first functionalities capable of being converted to second functionalities by exposure to an acid. A second coating conta...
05/08/2012
8170665Quantum dot labeled stem cells for use in providing pacemaker function
The present invention provides methods and compositions relating to the labeling of target cells with nanometer scale fluorescent semiconductors referred to as quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QD...
05/01/2012
8168786Radiolabeled compounds and uses thereof
The present invention relates to Radiolabeled Compounds and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositio...
05/01/2012
8168534Methods of fabricating electrodes and uses thereof
The present invention relates to methods for fabricating nanoscale electrodes separated by a nanogap, wherein the gap size may be controlled with high precision using a self-aligning aluminum oxide mask, such that the gap width depends upon the thickness of the alum...
05/01/2012
8167905Endovascular flexible stapling device
The present invention concerns a flexible stapling device (1). More particularly, this invention concerns a flexible endovascular stapling device (1) for an intavascular procedure such as patent foramen ovale closure, which is designed to avoid open he...
05/01/2012
8163508Methods for predicting pregnancy outcome in a subject by hCG assay
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ...
04/24/2012
8163065Carbon dioxide permeable membrane
A carbon dioxide permeable membrane is described. In some embodiments, the membrane includes a body having a first side and an opposite second side; a plurality of first regions formed from a molten carbonate having a temperature of about 400 degrees Celsius to abou...
04/24/2012
8158832Photochemical methods and photoactive compounds for modifying surfaces
Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can...
04/17/2012
8158420Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5
The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenit...
04/17/2012
8153113Method of increasing trafficking of endothelial progenitor cells to ischemia-damaged tissue
This invention provides a method of increasing trafficking of endothelial progenitor cells to ischemia-damaged tissue in a subject comprising administering to the subject an amount of interleukin-8 effective to attract endothelial progenitor cells to the ischemia-da...
04/10/2012
8150128Systems and method for composite elastography and wave imaging
Systems and methods for composite elastography and wave imaging are presented. In exemplary embodiments of the present invention an imaging modality field of view, such as, for example, that of ultrasound, can be divided into N sectors, each having 1/Nth of a full f...
04/03/2012
8144376Lensless imaging with controllable apertures
Embodiments of the present invention provide a lensless optical device for acquiring an image. The device can include a light attenuating layer having a plurality of elements, where transmittance of each of the plurality of elements is controllable, and an image det...
03/27/2012
8135994Methods, media, and systems for detecting an anomalous sequence of function calls
Methods, media, and systems for detecting an anomalous sequence of function calls are provided. The methods can include compressing a sequence of function calls made by the execution of a program using a compression model; and determining the presence of an anomalou...
03/13/2012
8133866Method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury
This invention provides for a method for inhibiting new tissue growth in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for...
03/13/2012
8133492Pneumococcus polysaccharide-related vaccines
This invention provides novel nitrocellulose-based or Hydrogel-based microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, (3) to determine whethe...
03/13/2012
8133239Method and apparatus for circulatory valve repair
An apparatus for the repair of a cardiovascular valve has leaflets comprising a grasper capable of grabbing and co-apting the leaflets of the valve. In a preferred embodiment, the grasper has jaws that grasp and immobilize the leaflets, and then a fastener is insert...
03/13/2012
8131616System and method for allocating resources using spot market and derivative market techniques
A method for controlling access to a system of finite resources with excess demand employs a two stage admission process. Subscribers are first admitted based on an initial bid price and resource availability. The market price is determined by the highest bid price ...
03/06/2012
8129121Regulation of lipid droplet formation by modulation of FIT1 and FIT2 and uses thereof
This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic screens for disorders and conditions involving regulation of fat sto...
03/06/2012
8128963Methods for treating ischemic disorders using carbon monoxide
The present invention provides for a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of a selectin antagonist in a sufficient amount over a sufficient time period to prevent white ...
03/06/2012
8124829Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof
The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter; and (b) a DNA sequence which encodes a receptor for advanced glycation endproducts (RAGE), wherein the promoter and ...
02/28/2012
8119782Medium scale integration of molecular logic gates in an automaton
The development of the first solution-phase molecular assembly comprising over 100 molecular logic gates, which more than quadruples the complexity performed by any previous system. “MAYA-II” is a second generation molecular automaton capable of playing a comple...
02/21/2012
8116886Electrode arrays and systems for inserting same
Electrode arrays and systems for inserting same are disclosed. In some embodiments, electrode arrays are provided, the electrode arrays comprising: a passive-bending portion; an active-bending portion coupled to the passive bending portion; a plurality of electrodes...
02/14/2012
8115873Object-based audio-visual terminal and bitstream structure
As information to be processed at an object-based video or audio-visual (AV) terminal, an object-oriented bitstream includes objects, composition information, and scene demarcation information. Such bitstream structure allows on-line editing, e.g. cut and paste, ins...
02/14/2012
8097650Method of treating a condition associated with phosphorylation of TASK-1
This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function...
01/17/2012
8097162Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled th...
01/17/2012
8096941Insertable device and system for minimal access procedure
The present invention provides a system and single or multi-functional element device that can be inserted and temporarily placed or implanted into a structure having a lumen or hollow space, such as a subject's abdominal cavity to provide therewith access to the si...
01/17/2012
8092684Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled th...
01/10/2012
8088575Massive parallel method for decoding DNA and RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction....
01/03/2012
8087784Systems and methods for displaying three-dimensional images
Systems and methods for displaying three-dimensional (3D) images are described. In particular, the systems can include a display block made from a transparent material with optical elements three-dimensionally disposed therein. Each optical element becomes luminous ...
01/03/2012
8086409Method of selecting genes from continuous gene expression data based on synergistic interactions among genes
Systems and methods for selecting factors from a continuous data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified....
12/27/2011
8084593Polynucleotide encoding a TRIM-Cyp polypeptide, compositions thereof, and methods of using same
The invention provides an isolated nucleic acid encoding a TRIM—cyclophilin A fusion sequence encoding a TRIMcyp fusion protein which is active as an anti-viral agent, and in particular an anti-HIV-1 agent. The invention provides for a nucleic acid encoding a poly...
12/27/2011
8084204Displacement assay for detection of small molecules
Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 μM. Mechanistic studies indicate an intermolecular displacement of t...
12/27/2011
8083706Apparatus and systems for membraneless separation of fluids
The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, ...
12/27/2011
8080281Growth and applications of ultralong carbon nanotubes
Ultralong carbon nanotubes can be formed by placing a secondary chamber within a reactor chamber to restrict a flow to provide a laminar flow. Inner shells can be successively extracted from multi-walled carbon nanotubes (MWNTs) such as by applying a lateral force t...
12/20/2011
8078257Complex amplitude modulation in blood flow and perfusion measurement for measuring a distribution of transit times on a voxel by voxel basis
Systems and methods for blood flow and perfusion measurement using complex amplitude modulation of MRI pulses are presented. In exemplary embodiments of the disclosed subject matter, inflowing arterial spins can be modulated using a complex modulation function havin...
12/13/2011
8074115Methods, media and systems for detecting anomalous program executions
Methods, media, and systems for detecting anomalous program executions are provided. In some embodiments, methods for detecting anomalous program executions are provided, comprising: executing at least a part of a program in an emulator; comparing a function call ma...
12/06/2011
8067462Processes of making sesquiterpenoid tashironin, its analogs and their uses
A compound having the structure of the formula (genus of compound 1 excluding Tashironin or Debenzoyltashironin) and methods of the same. ...
11/29/2011
8067371RAGE G82S-related methods and compositions for treating inflammatory disorders
This invention provides methods, compositions and articles of manufacture for inhibiting the onset of and treating inflammatory disorders such as rheumatoid arthritis. The instant invention is based on the blockade of RAGE G82S function. ...
11/29/2011
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