Assignee: The Wistar Institute

Location: Philadelphia, PA
No. of patents: 64

Number	Title	Issue Date
8180580	Method for identifying a compound that modulates SIR2 protein activity The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid re...	05/15/2012
8137972	Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds...	03/20/2012
8067012	Treatment of melanoma using HSV mutant Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the γ34.5 gene in the long repeat region (RL) such that the γ34.5 gene is a non-functional, manufacture of medicaments and methods of testi...	11/29/2011
7740860	Composition and method for preventing or treating a virus infection The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. ...	06/22/2010
7691976	BRAF35 protein and BRCA2/BRAF35 complex and methods of use An isolated nucleic acid sequence of BRAF35 and polypeptides encoded thereby are provided, as well as a multiprotein complex, and an antibody capable of binding selectively to the BRAF35 protein. Related agents and compositions which modulate interaction between BRC...	04/06/2010
7674468	Treatment of cancer using HSV mutant Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the γ34.5 gene in the long repeat region (RL) such that the γ34.5 gene is a non-functional, manufacture of medicaments and methods of testi...	03/09/2010
7666983	Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 a...	02/23/2010
7544465	Methods and compositions for monitoring cell migration and identifying clinically relevant cytotoxic T lymphocyte activity A three-dimensional reconstruct model containing solid layers of collagen and fibroblasts closely mimic the condition of patients in vivo, preserving in vivo phenotypic and functional characteristics of the cells. Reconstructs can be used to detect cellular migratio...	06/09/2009
7527798	Composition and method for preventing or treating a virus infection The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. ...	05/05/2009
7514219	Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be used to distinguish between primary squamous cell carcinoma of the l...	04/07/2009
7473414	Compositions and methods for wound healing Mice in which enhance wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for treating wounds, including central and peripheral nerve wounds, are als...	01/06/2009
7402308	Method of delivering genes to the central nervous system of a mammal The invention provides a method of delivering a selected DNA sequence to the central nervous system of a mammal by administering to said mammal a neurotropic virus, said virus containing a selected DNA sequence under the control of a promoter which permits expressio...	07/22/2008
7354589	Multiple antigenic agents and methods for using the same The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. The multiple antigenic agents of the invention contain at least one of a B cell determinant, a T cell determinant, or a targeting molecule...	04/08/2008
7189801	Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360–386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53...	03/13/2007
7122633	Natural killer stimulatory factor This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical prep...	10/17/2006
7001759	Compositions and methods for delivery of genetic material Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the ...	02/21/2006
6852706	Methods and compositions for healing heart wounds Levels of thyroid hormone can be decreased in a mammal to increase healing of heart wounds. The increased wound healing includes rapid re-epithelialization and recovery of normal architecture and function relative to mammals who have not been treated according to th...	02/08/2005
6838236	VPR function and activity Pharmaceutical compositions comprising the HIV protein vpr or nucleic acid molecule encoding vpr are disclosed. Also disclosed are methods of treating patients suffering from diseases characterized by hyperproliferating undifferentiated cells such as cancer by admin...	01/04/2005
6638408	Method and device for separation of charged molecules by solution isoelectric focusing The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples ...	10/28/2003
6555579	Methods for reducing atherosclerotic plaques A method for reducing atherosclerotic plaques includes administering an effective amount of at least one fatty acid composition to an animal, said fatty acid composition having a carbon chain of at least 16 carbons in length, and wherein at least one pair...	04/29/2003
6555658	Antibodies to natural killer stimulatory factor This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmace...	04/29/2003
6538173	Compositions and methods for wound healing Mice in which enhance wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for treating wounds, including central and peripheral nerve woun...	03/25/2003
6468982	Genetic immunization Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an indiv...	10/22/2002
6420118	Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild...	07/16/2002
6221635	Methods for solid-phase amplification of DNA template (SPADT) using multiarrays The present invention relates to a novel method of detecting specific nucleic acids in a biological sample using solid-phase amplification of DNA template (SPADT) using multiarrays....	04/24/2001
6169073	Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild...	01/02/2001
6086876	Methods and compositions for the inhibition of interleukin-12 production The invention includes compositions and methods for selective suppression of IL-12 production in a cell. Methods of treating a human having a disease associated with dysregulated IL-12 production are also provided....	07/11/2000
5981505	Compositions and methods for delivery of genetic material Methods of inducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering...	11/09/1999
5874225	Identification of compounds that modulate HIV-1 vpr protein activity The present invention is directed toward methods of identifying compounds which inhibit the human immunodeficiency virus (HIV) viral protein R (Vpr) from stimulating the differentiation of undifferentiated cells. This invention takes advantage of the obse...	02/23/1999
5837249	Method for generating an immunogenic T cell response protective against a virus A novel method of presenting an immunogenic peptide to an antigen presenting cell (APC) of a mammalian host, in order to generate a T cell response protective against a virus, such as herpes or rabies virus, comprising administering an immunologically eff...	11/17/1998
5837460	Methods of identifying biologically active receptor-binding peptides A method of identifying peptides which mimic biologically active proteins is disclosed. The method comprises the steps of making a recombinant antibody library from genetic material obtained from an animal which has been immunized against antibodies that ...	11/17/1998
5830876	Genetic immunization A method of immunizing an individual against pathogen is disclosed. Also disclosed is a method of treating an individual who has a hyperproliferative disease, or of treating an individual who is infected by a pathogen. Specifically, the individual is inje...	11/03/1998
5817637	Genetic immunization Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an indiv...	10/06/1998
5668002	DNA and polypeptide for tumor-associated antigen CO-029 The human tumor-associated antigen CO-029 is a monoclonal antibody-defined, 27-34 kDa cell surface glycoprotein. A full-length cDNA clone for CO-029 is described. When transiently expressed in COS cells, the cDNA clone directs the synthesis of an antigen ...	09/16/1997
5637677	Biologically active compounds and methods of constructing and using the same A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein or which block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portio...	06/10/1997
5595869	Diagnostic methods for detecting lymphomas in humans The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes ...	01/21/1997
5593972	Genetic immunization Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an indiv...	01/14/1997
5523393	BCL-2 proteins The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes ...	06/04/1996
5506344	Antibodies specific for BCL-2 gene product The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes ...	04/09/1996
5470571	Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425 Monoclonal antibody 425 having properties particularly beneficial for anti-tumor therapy has been raised. MAb 425 antibody binds to EGF-receptors and inhibits their bioactivities. The amount of binding of the antibody to cancer cells can be increased by t...	11/28/1995

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Assignee: The Wistar Institute