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| Number | Title | Issue Date |
| 7972856 | Targeted gene modification by parvoviral vectors This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic mod... | 07/05/2011 |
| 7935352 | Compositions and methods for vaccinating against HSV-2 This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a ... | 05/03/2011 |
| 7910714 | Monomeric red fluorescent proteins Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use. ... | 03/22/2011 |
| 7888016 | Methods and compositions for predicting drug responses The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes deri... | 02/15/2011 |
| 7879339 | Compositions and methods for vaccinating against HSV-2 This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a ... | 02/01/2011 |
| 7875451 | Formulation to improve survival of transplanted cells The survival of cells during transplantation is enhanced. Cells to be transplanted are administered in a formulation that provides two ore more survival enhancing factors. Optionally, prior to administration, the cells are cultured in the presence of factors that en... | 01/25/2011 |
| 7851144 | Compositions and methods for detecting cancer The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at ris... | 12/14/2010 |
| 7829282 | Methods and compositions for predicting drug responses The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes deri... | 11/09/2010 |
| 7825391 | Plasma-based EUV light source Various mechanisms are provided relating to plasma-based light source that may be used for lithography as well as other applications. For example, a device is disclosed for producing extreme ultraviolet (EUV) light based on a sheared plasma flow. The device can prod... | 11/02/2010 |
| 7811819 | Cryopreservation of primate embryonic stem cells Primate embryonic stem cells are cryopreserved by resuspension in a freezing medium and slow cooling at a controlled rate. In some embodiments, prior to the controlled freezing step, the suspension of cells is cooled to a temperature just below freezing, and ice cry... | 10/12/2010 |
| 7807260 | Multi-layered foamed polymeric objects and related methods The invention disclosed herein relates to relates to foamed thermoplastic material objects and articles of manufacture having an internal layered cellular structure, as well as to methods of making the same. In one embodiment, the invention is directed to a multi-la... | 10/05/2010 |
| 7671185 | Monomeric red fluorescent proteins Disclosed are nucleotide sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use thereof. ... | 03/02/2010 |
| 7655467 | Compositions and methods for systemic nucleic acid sequence delivery The present invention provides systemic nucleic acid sequence delivery without conventional systemic administration aids (SAAs). In certain embodiments, vascular permeability agents (VPAs), such as VEGF, are used in conjunction with nucleic acid viral vectors, such ... | 02/02/2010 |
| 7585349 | Methods of nanostructure formation and shape selection Methods for forming nanostructures of various shapes are disclosed. Nanocubes, nanowires, nanopyramids and multiply twinned particles of silver may by formed by combining a solution of silver nitrate in ethylene glycol with a solution of poly(vinyl pyrrolidone) in e... | 09/08/2009 |
| 7575876 | Biomarkers for neurodegenerative disorders The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene product expression in a cerebrospinal fluid sample and comparing the... | 08/18/2009 |
| 7517851 | Chlamydia oligosaccharides Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells. ... | 04/14/2009 |
| 7402726 | Methods and compositions for screening for modulators of Parkinson's disease Methods and compositions for identifying an agent (e.g., a gene product or small molecule compound) that modulates a Parkinson's disease phenotype are provided. In practicing the subject methods, a non-mammalian animal model, such as Drosophila melanogaster, ... | 07/22/2008 |
| 7372059 | Plasma-based EUV light source Various mechanisms are provided relating to plasma-based light source that may be used for lithography as well as other applications. For example, a device is disclosed for producing extreme ultraviolet (EUV) light based on a sheared plasma flow. The device can prod... | 05/13/2008 |
| 7341869 | Compositions and methods for treating diabetes The present invention provides an isolated population of cells containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site and a glucose-regulated expressible nucleic acid encoding a protease capable of cleaving the proinsulin cl... | 03/11/2008 |
| 7250298 | Monomeric red fluorescent proteins Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use. ... | 07/31/2007 |
| 7053067 | oligosaccharides Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells. ... | 05/30/2006 |
| 7045344 | Adenoviral vector and methods for making and using the same In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods, the subject genomes are prepared from first and second vectors. The fi... | 05/16/2006 |
| 7027965 | Time domain passivity control of haptic interfaces Methods are provided for stabilizing a haptic interface of a computer-controlled one-port virtual-reality system or a two-port teleoperation system comprising a robot manipulator. “Stabilizing” means to reduce the sense of vibration in a haptic interface. A Pass... | 04/11/2006 |
| 6936243 | Adeno-associated viral vector-mediated delivery of DNA to cells of the liver The instant invention provides methods of expressing polynucleotides in the cells of the liver comprising administering viral particles comprising a recombinant AAV vector into a mammal, preferably a human. ... | 08/30/2005 |
| 6843375 | Magnetic separator for linear dispersion and method for producing the same A magnetic sector for charged particle beam transport that includes a magnetic field profile that achieves a linear dispersion from a collimated beam of charged particles proportional to their mass-energy-to-charge ratio. In one embodiment, the field profile necessa... | 01/18/2005 |
| 6703198 | Methods of diagnosing alagille syndrome The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The i... | 03/09/2004 |
| 6492560 | Discrete-length polyethylene glycols The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.... | 12/10/2002 |
| 6323313 | Annexin derivative with endogenous chelation sites Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X1 -Gly-X2, where X1 and X2 are selected from Gly ... | 11/27/2001 |
| 6294697 | Discrete-length polyethylene glycols The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.... | 09/25/2001 |
| 6277970 | PRP-like gene The present invention provides nucleic acids encoding the Doppel ("Dpl") protein, Dpl peptides, and assays utilizing the Dpl nucleic acids and/or peptides. In related aspects the invention features expression vectors and host cells comprising nucleic acid... | 08/21/2001 |
| 6197932 | Modulators of actin The invention provides methods and compositions which find use, inter alia, for modulating the stabilization of actin filaments. The compositions may comprise one or more polypeptide moieties derived from a novel human diaphanous polypeptide and/or one or... | 03/06/2001 |
| 6177410 | Therapeutic methods for prostate cancer Therapeutic methods for the treatment of prostate cancer are described. The methods include a gene therapy method for prostate cancer using the BRCA family of genes, including the BRCA1 and BRCA2 genes. The BRCA family of gene products inhibit the growth ... | 01/23/2001 |
| 6131580 | Template imprinted materials by RFGD plasma deposition Template-imprinted structures 10 are provided having at least one template-imprinted surface 12 defining indentations 14 that are capable of specifically binding cells and/or molecules, such as macromolecules including proteins, peptides and nucleic acids... | 10/17/2000 |
| 6107626 | Device and method for forming ions A device and method for forming ions by inductive ionization is disclosed. The device is an ion source that includes a capacitor having a pair of electrodes separated by a dielectric material. The method of the invention uses the capacitor-based ion sourc... | 08/22/2000 |
| 6083926 | Water soluble vitamin B12 receptor modulating agents and methods related thereto Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bo... | 07/04/2000 |
| 6015565 | Glycoprotein B of the RFHV/KSHV subfamily of herpes viruses This invention relates to polynucleotides encoding Glycoprotein B from the RFHV/KSHV subfamily of gamma herpes viruses, three members of which are characterized in detail. DNA extracts were obtained from Macaque nemestrina and Macaque mulatta monkeys affe... | 01/18/2000 |
| 5985574 | Modulators of actin The invention provides methods and compositions which find use, inter alia, for modulating the stabilization of actin filaments. The compositions may comprise one or more polypeptide moieties derived from a novel human diaphanous polypeptide and/or one or... | 11/16/1999 |
| 5980246 | Orthodontics headgear compliance monitor This invention is an apparatus and method for monitoring and motivating user compliance for orthodontic headgear (24) of the type using a linear spring force module (22). The spring force module (22) includes first (38) and second opposite attachment memb... | 11/09/1999 |
| 5726364 | Sample introduction apparatus for a flow cytometer A sample introduction system for a flow cytometer allows easy change of sample containers such as test tubes and facilitates use in high pressure environments. The sample container includes a cap having a pressure supply chamber and a sample container att... | 03/10/1998 |
| 5700266 | System for repair of capsulo-labral separations An elongated drill and suture guide is inserted through a posterior portal during arthroscopic surgery to repair a capsulo-labral separation. The drill and suture guide has a linear longitudinal bore for a drill pin to bore through the glenoid rim of the ... | 12/23/1997 |
