Assignee: The University of Virginia Patent Foundation

Location: Charlottesville, VA
No. of patents: 50

Number	Title	Issue Date
7442687	2-polycyclic propynyl adenosine analogs having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein. ...	10/28/2008
6660276	Peptides recognized by melanoma-specific cytotoxic lymphocytes, and uses therefor The instant disclosure identifies and synthesizes peptide residues initially isolated from a melanoma cell line. The peptides are capable of reconstituting an epitope recognized by tumor specific CTL. Some of the sequences are homologous with proteins ide...	12/09/2003
6617355	Treating asthma by preventing and/or accomodating S-nitrosothiol breakdown Asthma is ameliorated, and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown....	09/09/2003
6596534	Utilization of osteocalcin promoter to deliver therapeutic genes to tumors A therapeutic agent based on a recombinant adenovirus which employs an osteocalcin promoter for the expression of thymidine kinase can be administered intravascularly to treat metastatic cancer, including osteosarcoma, breast cancer, prostate cancer, ocul...	07/22/2003
6572856	Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies The present invention relates to the treatment and prevention of cancer, viral infections and microbial infections by the administration of anti-C3b(i) antibodies. The present invention also relates to methods of treating and preventing cancer, viral infe...	06/03/2003
6558671	Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor Cysteine-depleted CTL epitopes can elicit a stronger or more specific CTL response than the native, cysteine-containing CTL epitope of a disease associated antigen....	05/06/2003
6413967	Inhibition of novel calcium entry pathway in electrically non-excitable cells acting as an anti-proliferative therapy The present invention provides methods for screening for voltage gated (VG)-selective inhibitors, novel VG-selective inhibitors, compositions containing the same, methods for inhibiting calcium entry into electrically non-excitable cells with said VG-sele...	07/02/2002
6330469	Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability i...	12/11/2001
6216032	Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness In one aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature n...	04/10/2001
6192320	Interactive remote sample analysis system An interactive multi-station medical specimen analysis system for simultaneously analyzing a medical specimen at remote locations and accessing, for evaluation, the results of each of the analyses at a central laboratory is disclosed. A central laboratory...	02/20/2001
6180612	Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc...	01/30/2001
6159467	In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy A therapeutic agent based on a recombinant adenovirus which employs an osteocalcin promoter for the expression of thymidine kinase can be administered intravascularly to treat metastatic cancer, including osteosarcoma, breast cancer, prostate cancer, ocul...	12/12/2000
6096021	Flow arrest, double balloon technique for occluding aneurysms or blood vessels A method for occluding aneurysms or peripheral blood vessels is provided which allows for isovolumetric, isobaric delivery of occluding agents to aneurysms or peripheral blood vessels, wherein the aneurysms or peripheral blood vessels are isolated from th...	08/01/2000
6093697	Synthetic insulin mimetic substances Compounds are disclosed which have the formula (I) ##STR1## wherein R1 -R2 are each independently selected from the group consisting of: (a) a hydrogen atom; and (b) a lower alkyl group, straight or branched chain, having 1 to 8...	07/25/2000
6075057	Inhibition of carbohydrates metabolism by quinone compounds Optically pure enantiomers of avarol are obtained. The enantiomers of avarol are demonstrated to be highly effective inhibitors of ଱-glucosidase and ଱-mannosidase. Other enzymes assayed were not inhibited by these optically pure compounds. Inh...	06/13/2000
6034133	Use of a virucidal hand lotion to prevent the spread of rhinovirus colds Frequent application of a virucidal hand lotion containing malic acid, citric acid, and a C1-6 alcohol will prevent the hand-to-hand transmission of rhinoviruses and reduce the incidence of the "common cold" caused by rhinoviruses....	03/07/2000
6004986	Method for treating cerebral vasospasm and cerebral ischemia using iron chelators and pharmaceutical compositions therefor The invention relates to methods for treating cerebral vasospasm induced by hemorrhage or cerebral ischemia, by treating patients with a therapeutically effective amount of a lipophilic iron chelator....	12/21/1999
5986275	Reusable shielded marker for nuclear medicine imaging A reusable shielded marker for nuclear medicine imaging provides a chamber of radiation-shielding material such as lead to receive the radiodnuclide such as technetium pertechnetate. The chamber is mounted on a spring which also bears a shutter provided w...	11/16/1999
5973114	Isolation and characterization of the growth hormone releasing hormone receptor Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the recepto...	10/26/1999
5966424	Radiation-shielding, interpolative-sampling technique for high spatial resolution digital radiography A method of obtaining high resolution, spatial images from a flat-panel imager is provided, in which a radiation opaque filter is provided over the flat-panel imager, interposed between the x-ray source and the patient tissue. The filter, comprised of x-r...	10/12/1999
5962239	Method for detection of anti-HLA antibodies An improved method for detecting even low titer HLA antibodies in proposed organ transplant recipients employs flow cytometry crossmatching (FCXM) on pronase-treated B-cells and T-cells of the donor. Two-color FCXM is preferably employed. The peripheral b...	10/05/1999
5902787	Chemically modified a-macroglobulins, methods of making, and methods of using the same in anti-cytokine therapy Chemically modified ଱-macroglobulin is conformationally locked by cross-linking 댒 M with a bi-functional peptide crosslinker, and then modified with methylamine, to provide conformational intermediates with limited conformational c...	05/11/1999
5895843	In situ sensor for critical corrosion conditions in a material An in situ sensor for monitoring the degree of corrosion of rebar in a concrete structure relies on a four-point resistance measure of a test wire embedded in the concrete structure. The resistance across the wire is compared with the resistance of a refe...	04/20/1999
5891634	Transfection of enteric parasites The invention provides methods for expressing foreign genes in enteric protozoa. This transfection system was established using a gene ligated to the 5' and 3' flanking DNA regions of a protein-encoding gene from an enteric protozoa. The present invention...	04/06/1999
5885791	Antifungal and antibacterial susceptibility assay An assay and test kit for testing and quantifying fungal inhibition by an antifungal agent. In the assay, inhibition is measured by a reduction in substrate uptake (such as glucose) as compared to uninhibited controls. A minimum inhibitory concentration v...	03/23/1999
5869288	Molecular cloning of cockroach allergens, amino acid and nucleotide sequences therefore and recombinant expression thereof Four cockroach allergens are purified, described, characterized and sequenced. The nucleotide sequence responsible for expression of the allergen, and the amino acid sequence thereof, are set forth. These allergens induce IgE antibody binding, which may g...	02/09/1999
5852187	Molecular cloning of the ovine pituitary growth hormone releasing hormone receptor Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the recepto...	12/22/1998
5834644	Automatic atomic force microscope with piezotube scanner An atomic force microscope which can provide an automatic operation of focusing a laser beam onto a cantilever of the atomic force microscope, and which can ensure that a laser beam reflected off this cantilever is properly directed to a detector. A tip s...	11/10/1998
5830472	Purified sperm surface antigen, monoclonal antibody therefor and applications therefor The monoclonal antibody S19, expressed by Deposit HB12144, ATCC, effectively agglutinates a sperm surface glycoprotein, SAGA-1 protein. The mAB finds utility as a binding agent in a spermicide, showing a high degree of effectiveness in binding potential s...	11/03/1998
5814066	Reduction of femoral arterial bleeding post catheterization using percutaneous application of fibrin sealant Post catheterization arterial bleeding is reduced by introduction of a fibrin sealant, prepared from fibrinogen and thrombin, into the periarterial tissue surround the arteriotomy through which the catheter was inserted. The fibrin sealant is introduced a...	09/29/1998
5808445	Method for monitoring remaining battery capacity A complete energy management system for lead-acid batteries. The system is designed for deep discharge batteries in traction vehicle type applications such as electric wheelchairs, electric vehicles, golf carts, or industrial equipment, where more efficie...	09/15/1998
5792215	Laser integrated targeting and entry system and method A guidance system and method for accurately reproducing surgical approach angles for increasing the efficiency and accuracy of image-guided biopsy procedures which require high levels of precision with respect to the orientation of surgical instruments pr...	08/11/1998
5772993	Osteocalcin promoter-based toxic gene therapy for the treatment of calcified tumors and tissues A recombinant adenovirus Ad-OC-TK was constructed, with cell specific gene expression, which contains osteocalcin (OC) promoter that drives the expression of herpes simplex virus thymidine kinase (TK); the addition of acyclovir (ACV), a pro-drug for the i...	06/30/1998
5750348	Method for detecting insulin resistance The present invention provides a new method for screening for insulin resistance that utilizes both myoinositol and chiroinositol as indicators. According to this method, levels of myoinositol and D-chiroinositol are measured. The value of the concentrati...	05/12/1998
5730958	Method of treatment of gastroesophageal reflux disease by enhancement of salivary esophageal protection due to mastication Prolonged mastication is demonstrated to enhance salivary secretion as well as enhance secretion of salivary components such as salivary bicarbonate, epidermal growth factor, mucin, PGE2 and transforming growth factor଱. Mastica...	03/24/1998
5696229	Polypeptide with laminin cell adhesion and morphogenesis activity The present invention provides novel cell adhesion peptides....	12/09/1997
5665565	Transfection of enteric parasites The invention provides methods for expressing foreign genes in enteric protozoa. This transfection system was established using a gene ligated to the 5' and 3' flanking DNA regions of a protein-encoding gene from an enteric protozoa. The present invention...	09/09/1997
5644046	Cloning of a gene encoding for the growth hormone releasing hormone receptor Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the recepto...	07/01/1997
5635540	Stabilized topical pharmaceutical preparations The present invention relates to stabilized topical pharmaceutical preparations. More specifically the present invention relates to a stabilized topical pharmaceutical preparation, based on the solubilization of a eutectic mixture of local anesthetic agen...	06/03/1997
5626691	Bulk nanocrystalline titanium alloys with high strength Bulk nanocrystalline Ti-based alloys were produced by conventional cooling from the corresponding liquid or high temperature solid phase followed by annealing at an appropriate temperature for a certain amount of time. The titanium-based alloys have a com...	05/06/1997

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Assignee: The University of Virginia Patent Foundation