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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 6216030 | Magnetic stereotactic system for treatment delivery A magnetic stereotactic system for treatment delivery includes a plurality of magnetic coils arranged to at least partially to surround a body part and generate a changeable magnetic field to guide a magnetic object within the body part; and at least one ... | 04/10/2001 |
| 5895812 | Diagnostic for Sjogren's syndrome The present invention relates to a novel polypeptide which has secretion enhancing activity on lacrimal and parotid gland cells, monoclonal antibodies thereto, and methods of diagnosising Sjorgren's syndrome using these antibodies.... | 04/20/1999 |
| 5779694 | Magnetic stereotactic system for treatment delivery A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transpor... | 07/14/1998 |
| 5707335 | Magnetic stereotactic system and treatment delivery A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transpor... | 01/13/1998 |
| 5602005 | Primate intra-acrosomal sperm antigen for use in a contraceptive vaccine A substantially purified intra-acrosomal primate sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with primate sperm after the acrosome reaction. In particular, it remains associated with the inner and ou... | 02/11/1997 |
| 5436157 | Human intra-acrosomal sperm antigen A substantially purified intra-acrosomal human sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with human sperm after the acrosome reaction. In particular, it remains associated with the inner and outer ... | 07/25/1995 |
| 5420024 | Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea An immobilized lipase is employed in an organic solvent to esterify diol lactone derivatives of HMG-CoA reductase inhibitors to form HMG-CoA reductase inhibitors of formula (I). ##STR1## This process allows for the efficient, one-step production of H... | 05/30/1995 |
| 5272058 | Diagnostic methods for E. histolytica A simple immunoassay method is provided which distinguishes pathogenic from nonpathogenic forms Entamoeba histolytica in biological samples. This assay utilizes monoclonal antibody preparations which are specific for designated epitopes of the 170 kd subu... | 12/21/1993 |
| 5264418 | Hemolymphopoietic growth factors, process for purifying and producing hemolymphopoietic growth factors and pharmaceutical compositions made therefrom This invention relates to hemolymphopoeitic growth factors (HLGF-1) that synergize with CSF-1, IL3 and GM-CSF and have pre-B cell potentiating activity. The invention also relates to a process for purifying such HLGF-1's from murine marrow cells and for p... | 11/23/1993 |
| 5260429 | Purified DNA of the 170-kd surface Gal/GalNAc adherence lectin of pathogenic E. histolytica cDNA encoding the 170 kd subunit of Gal/GalNAc lectin in various strains of E. histolytica is provided. Availability of this cDNA permits the use of diagnostic assays to distinguish pathogenic from nonpathogenic strains based on DNA hybridization, and fur... | 11/09/1993 |
| 5124360 | Dietary supplement for insulin-resistant diabetics A dietary supplement for the therapeutic treatment of those exhibiting clinical symptoms of insulin-resistant type II diabetes, and preventing the development of clinical symptoms in those genetically predisposed to the development of such symptoms, is pr... | 06/23/1992 |
| 5122603 | Purified insulin mediators and purification process for same A method for purifying two distinct insulin mediators to substantial homogeneity, and relative purity values above 80%, comprises adsorption on first anion exchange resin and subsequently on a chelex cation exchange resin column. The chelex resin ion exch... | 06/16/1992 |
| 5047508 | Monoclonal antibody to MHS-5; a new probe for sexual assault analysis A monoclonal antibody MHS-5 which specifically binds to a seminal vesicle specific antigen, SVSA, wherein the seminal vesicle specific antigen is secreted by the principal cells of the seminal vesicle epithelium. The method for producing this monoclonal a... | 09/10/1991 |
| 5036045 | Method for increasing growth hormone secretion A method for increasing growth hormone secretion or inducing the biologic effects of growth hormone by continuous administration of growth hormone releasing factor or analog thereof is disclosed.... | 07/30/1991 |
| 5017378 | Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres A method for increasing fertility in males with impairment of testosterone synthesis, comprising the step of injecting slow-release microcapsules or microspheres containing testosterone directly into the testes. The testosterone-laden microcapsules or mic... | 05/21/1991 |
| 5009634 | Metabolic catheter A metabolic catheter and method which allows the simultaneous removal of body fluids from organs and immediate addition of stop solution to the body fluid at the catheter tip to prevent degradation of the metabolite to be measured.... | 04/23/1991 |
| 5004608 | Amebiasis vaccine Purified Gal/GalNAc adherence lectin of Entamoeba histolytica is used for development of a vaccine to prevent human amebiasis.... | 04/02/1991 |
| 4947417 | Adjusting arrangement for radio-diagnostic equipment An effective ray beam includes an arc-shaped cut-out element having its open side facing in the direction toward the center of a ray beam. Via a variable arrangement of the arc-shaped cut-out element in a plane perpendicular to the ray beam, the effective... | 08/07/1990 |
| 4932944 | Intravenous port injection and connector system A connector has one end for receiving a standard auxiliary line adaptor hub and an opposite end receivable over an intravenous line port in a male-female interference fit. A needle is provided in the interior of the connector and punctures a sealing membr... | 06/12/1990 |
| 4923801 | Compositions and methods for the enrichment and isolation of Campylobacter pylori and related organisms from biological specimens and the environment A method of enrichment and isolation of urease producing organisms from a contaminated specimen by first homogenizing the contaminated specimen in water, then introducing the homogenized contaminated specimen into a solution of urea in an acid, wherein so... | 05/08/1990 |
| 4904472 | Use of adenosine antagonists in the treatment of bradyarrhythmias and mechanical dysfunction associated with cardiopulmonary resuscitation A method to enhance the efficacy of cardioversion, defibrillation, cardiac pacing, and cardiopulmonary resuscitation and to treat post-resuscitation asystole, bradyarrhythmias, electromechanical dissociation, and hemodynamic collapse by administering to a... | 02/27/1990 |
| 4902296 | Use of demineralized bone matrix in the repair of segmental defects A grafting material comprising milled bone which has an initial coating of guanidine-extracted bone proteins which are dialyzed from solution. Unbound bone proteins are removed and this augmented milled bone is lyophized. A subsequent coat of anti-coagula... | 02/20/1990 |
| 4869247 | Video tumor fighting system A destructive heat lesion is placed in any location in the brain. A patient's head is secured within a stereotactic frame. After a high resolution CT scan and angiogram or MRI, data is incorporated and analyzed by a computer. This information is then resy... | 09/26/1989 |
| 4867154 | Endotracheal tube stabilizing devices Frames for endotracheal tubes are disclosed. One device consists of a U-shaped band made of semirigid plastic material which passes over the patient's lower face and which attaches at either end to the patient's cheeks and/or temples. The part of the band... | 09/19/1989 |
| 4852596 | Micro slide irrigating unit A slide irrigating unit has two plexiglass boxes, an inner box forming an irrigating chamber and an outer box forming a drain box. The outer drain box is tightly sealed and its inner walls form the perimeters of the inner box which is open at the top. PVC... | 08/01/1989 |
| 4840076 | Lever drive apparatus An apparatus for propelling a wheeled vehicle which has a hand-manipulated lever that is connected to a clutch assembly. The clutch assembly has a drum that is rotatably connected to the vehicle and brake bands that are pivotably connected to the lower en... | 06/20/1989 |
| 4812040 | Hollow cathode plasma plume Sample material is sputtered from an orifice in a disc mounted in a hollow cathode. A plasma plume is ejected from the orifice and the material sputtered from the smaple is transported directly into the base of the plasma plume. Collisions with particles ... | 03/14/1989 |
| 4781692 | Retractable safety needles A flexible plastic catheter extends from a distal end of a rigid plastic housing. An elastomeric seal at the distal end of the housing tightly fits within the housing and grips in its bore a stylet. The stylet has a sharp distal end and an enlarged proxim... | 11/01/1988 |
| 4743259 | Use of demineralized bone matrix in the repair of segmental defects A process of grafting material from milled bone is disclosed which comprises augmenting the bone protein of a first quantity of milled bone by dialyzing from solution guanidine-extracted bone proteins from a second quantity of milled bone and adding the e... | 05/10/1988 |
| 4741998 | Monoclonal antibody to MHS-5: a new probe for sexual assault analyses A new probe for forensic analysis of sexual assaults is disclosed. The probe is a monoclonal antibody to a new protein marker, MHS-5, in semen. Also disclosed is the hybridoma producing the antibody as well as an assay utilizing the antibody for forensic ... | 05/03/1988 |
| 4735898 | Monoclonal antibodies and method of identifying species using the same The new method an products recognize human serum albumin, differentiating blood and tissue from human sources from blood and tissue of other animals. The method and products are particularly useful in forensic investigations. First, mice are injected with... | 04/05/1988 |
| 4676783 | Retractable safety needle An intravenous needle with a sharpened distal end has a proximal end fixed within a first enlarged end of an inner tube. The enlarged end of the inner tube is held tightly within a first end of an outer tube by friction. The needle passes through a constr... | 06/30/1987 |
| 4673563 | Adenosine in the treatment of supraventricular tachycardia A method of diagnosing and treating arrhythmias caused by re-entry in the A-V node by administering to a human or animal an effective amount of adenosine that restores normal sinus rhythm.... | 06/16/1987 |
| 4592744 | Self-resheathing needle assembly A self-resheathing safety needle has a case with a small closed end and a large open end and a needle assembly within the case with the needle projecting through the small closed end. A hub is connected to the needle assembly inside the case and a connect... | 06/03/1986 |
| 4581011 | Prepackaged manual administration set for acute peritoneal dialysis in infants and adults A manual administration set for acute peritoneal dialysis in infants and adults is disclosed which has a minimum of connections so as to minimize risk of infection and includes a heating means for patient comfort and performance of more efficient dialysis... | 04/08/1986 |
| 4528207 | Plated dental amalgam alloys Dental alloy particles having a coating of a silver-tin alloy are prepared by a process comprising codepositing silver and tin from a cyanide based plating solution containing silver and tin ions on a particulate metal substrate having a particle size suf... | 07/09/1985 |
| 4446064 | Insulin mediator substance An insulin mediator substance produced by the process comprising: contacting muscle tissue with insulin; deproteinizing the muscle tissue; removing the major nucleotides from the deproteinized muscle tissue; chromatographing the so-treated product on a Se... | 05/01/1984 |
| 4384943 | Fluid treatment Methods and apparatus for electrochemically disinfecting or treating contaminated aqueous liquids by contact disinfection and/or the generation of a biocidally active chemical agent in the liquid being treated. Rapid polarization of reactor electrodes aft... | 05/24/1983 |
| 4358699 | Versatile electrical fiber brush and method of making A versatile electrical fiber brush comprising the following components: Firstly a brush body, which is not necessarily equiaxed, non-porous, rigid or all in one piece, made of a matrix material, not necessarily electrically conductive, embedded in which i... | 11/09/1982 |
| 4319562 | Method and apparatus for permanent epicardial pacing or drainage of pericardial fluid and pericardial biopsy A method and apparatus for providing permanent epicardial pacing comparable to permanent transvenous pacing in the acutely ill or debilitated patient under local anesthesia and for drainage of pericardial fluid and pericardial biopsy. The apparatus includ... | 03/16/1982 |
