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Assignee: The University of Toledo


Location: Toledo, OH
No. of patents: 99

1      
NumberTitleIssue Date
8173869Plants expressing environmental stress tolerances having petunia CBF genes therein
The present invention provides a method of controlling a plant's tolerance to environmental stress and to a transgenic plant having the desired characteristics. ...
05/08/2012
8152852Variable height vertebral body replacement implant
A variable height vertebral body replacement implant used in corpectomy surgery to provide support in place of a removed or damaged vertebrae, and contain and compact bone graft material. ...
04/10/2012
8143072System for detecting nanoparticles using modulated surface plasmon resonance
A method and system for detecting magnetic nanoparticles include measuring a magneto-optical enhancement of the plasmon absorption in the optical response. ...
03/27/2012
8133491Compositions and methods for treatment of hyperplastic disorders
A method for treating a subject includes injecting a therapeutic amount of a composition derived from a cobra toxin into a tissue of the subject in an amount sufficient to diminish at least one symptom of a hyperplastic disorder. ...
03/13/2012
8030120Hybrid window layer for photovoltaic cells
A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-wind...
10/04/2011
8030030Biomass pretreatment
A method for lignocellulose conversion to sugar with improvements in yield and rate of sugar production has been developed by using ionic liquid pretreatment. This new pretreatment strategy substantially improves the efficiency (in terms of yield and reaction rates)...
10/04/2011
7994279Altered peptide ligands of GAD65
Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-...
08/09/2011
7957609System for extended high frame rate imaging with limited-diffraction beams
The present invention provides a method and a system for producing an image using an imaging system by weighting: i) the signals transmitted from at least one element of a transducer array to form limited diffraction transmitted beams or the transmitted beams are st...
06/07/2011
7879644Hybrid window layer for photovoltaic cells
A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-wind...
02/01/2011
7750234Integrated photoelectrochemical cell and system having a liquid electrolyte
An integrated photoelectrochemical (PEC) cell generates hydrogen and oxygen from water while being illuminated with radiation. The PEC cell employs a liquid electrolyte, a multi-junction photovoltaic electrode, and a thin ion-exchange membrane. A PEC system and a me...
07/06/2010
7674608Saccharifying cellulose
Dissolution, partial dissolution or softening of cellulose in an ionic liquid (IL) and its subsequent contact with anti-solvent produces regenerated cellulose more amorphous in structure than native cellulose, which can be separated from the IL/anti-solvent mixture ...
03/09/2010
7667418Control system for bearingless motor-generator
A control system for an electromagnetic rotary drive for bearingless motor-generators comprises a winding configuration comprising a plurality of individual pole pairs through which phase current flows, each phase current producing both a lateral force and a torque....
02/23/2010
7667133Hybrid window layer for photovoltaic cells
A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-wind...
02/23/2010
7456537Control system for bearingless motor-generator
A control system for an electromagnetic rotary drive for bearingless motor-generators comprises a winding configuration comprising a plurality of individual pole pairs through which phase current flows, each phase current producing both a lateral force and a torque....
11/25/2008
7417407Circuit with a switch for charging a battery in a battery capacitor circuit
A circuit for charging a battery combined with a capacitor includes a power supply adapted to be connected to the capacitor, and the battery. The circuit includes an electronic switch connected to the power supply. The electronic switch is responsive to switch betwe...
08/26/2008
7245952Noninvasive birefringence compensated sensing polarimeter
The present invention relates to a system and method for compensating for the effects of birefringence in a given sample and employs an optical birefringence analyzer to sense the real-time birefringence contributions and then provides a feedback signal to a compoun...
07/17/2007
7164027Aralkyl ester soft drugs
The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is administered. The parent drug comp...
01/16/2007
7105635Cyclic beta-sheet peptides useful as apoptotic/cytotoxic cancer agents
Peptides and pharmaceutical compositions of matter useful as cytotoxic compositions particularly for, but not limited to, treatment of cancers, that includes a synthetic peptide whose amino acid sequence is different from an initial loop of cobra cardiotoxin. ...
09/12/2006
7049326Method and compositions for temporarily incapacitating subjects
A method for modifying at least one non-ester-containing parent compound, and the compounds produced using such method, which compounds are deployed to temporarily incapacitate at least one subject are disclosed. The modified compounds are rapidly metabolized to ina...
05/23/2006
6958078Bioartificial intervertebral disc
A bioartificial nucleus pulposus is adapted for replacing at least a portion of a natural nucleus pulposus in an intervertebral disc. The bioartificial nucleus pulposus includes an artificial support structure made from a biodegradable material. The support structur...
10/25/2005
6846937Method for the selective removal of acyl-functionality attached to the 2'-hydroxy-group of paclitaxel-related derivatives
A method for removing acyl-groups appended by an ester linkage to the 2′-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2′,7-bis-Monochloroacetylpaclitaxel analogs are converted to their corr...
01/25/2005
6756047Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious parent drug compound so as to re...
06/29/2004
6755151Hot-filament chemical vapor deposition chamber and process with multiple gas inlets
A thin film deposition method uses a vacuum confinement cup that employs a dense hot filament and multiple gas inlets. At least one reactant gas is introduced into the confinement cup both near and spaced apart from the heated filament. An electrode inside the confi...
06/29/2004
6750238Aralkyl ester soft drugs
The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is administered. The parent drug comp...
06/15/2004
6731388Method of measuring surface plasmon resonance using interference structure of reflected beam profile
Changes in optical properties of layered materials are measured by directing an incident wave of finite transverse dimensions toward layered materials under conditions that will produce a propagating surface mode or a waveguide mode in the layered materials. The int...
05/04/2004
6638839Hot-filament chemical vapor deposition chamber and process with multiple gas inlets
A thin film deposition method uses a vacuum confinement cup that employs a dense hot filament and multiple gas inlets. At least one reactant gas is introduced into the confinement cup both near and spaced apart from the heated filament. An electrode insid...
10/28/2003
6602891Muscarinic receptor agonists
A compound of Formula (III): ##STR1## wherein X is a linkage independently selected from (CH2)12 or (CH2 CH2)4 O3 and wherein R3 is independently selected from H, CH2 ...
08/05/2003
6536258Blast load simulation system
A blast load simulation system includes a glass panel having two surfaces. The system also includes a membrane for covering at least one of the two surfaces of the glass panel. The system also includes means for delivering an impulse with a given characte...
03/25/2003
6498829Method for measurement of physical characteristics of crystals
A method and apparatus to simultaneously measure the diffraction resolution and mosaic spread of macromolecular crystals, are described. The method includes minimizing contributions of an x-ray beam to any reflection angular widths in the crystal, rapidly...
12/24/2002
6495680Helices and nanotubes on folding compositions and method of making same
Helical oligomer and polymer compositions that form nanotubes are described. The compositions comprise a plurality of aromatic substituents linked by at least one amide group. The compositions have a curved backbone due to intramolecular hydrogen bonds th...
12/17/2002
6376675Muscarinic receptor agonists
A compound of Formula (III): ##STR1## wherein X is a linkage independently selected from (CH2)12 or (CH2 CH2)4 O3 and wherein R3 is independently selected from H, CH2 ...
04/23/2002
6369081Muscarinic receptor agonists
A compound of Formula (I): ##STR1## wherein R is a linkage independently selected from (CH2)12 or (CH2)4 O3 ; and acid addition salts, solvates and hydrates thereof. The compounds have unusually high ...
04/09/2002
6302360Vortex generation for control of the air flow along the surface of an airfoil
Apparatus for generating vortices to control the flow of air across a airfoil of an aircraft includes a series of pressure active regions arranged along the leading edge of the airfoil. The pressure active regions include spaced apart valves connected to ...
10/16/2001
6298607Venting-membrane system to mitigate blast effects
A venting-membrane system for mitigating blast pressure generated from a blast force on a wall structure. The venting-membrane system having a framework including a plurality of parallel structural members defining a wall structure having an interior surf...
10/09/2001
6294152Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging
A compound of formula (I): ##STR1## wherein, R1 is independently selected from methyl and ethyl and R2 is independently selected from hydrogen, alkyl, and substituted alkyl. The compound is capable of functioning as a ligand and comp...
09/25/2001
6255540Methods for producing two-substituted glycerols having various levels of protection
A method for producing 2-substituted glycerols having various levels of hydroxy group protection by opening dihydroxyacetone dimer in a nonaqueous, non-protic environment with a composition that initially protects both of the liberated 1,3-dihydroxy group...
07/03/2001
6146615Contrast agents for image enhancement in magnetic resonance imaging
A compound of formula (I): ##STR1## wherein, R1, R2, R3 and R4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R1, R2 and ...
11/14/2000
6096767Muscarinic receptor agonists
A compound of Formula (I): ##STR1## wherein R is a linkage independently selected from (CH2)12 or (CH2)4 O3 ; and acid addition salts, solvates and hydrates thereof. The compounds have unusually ...
08/01/2000
6011563Computer controlled photoirradiation during photodynamic therapy
A system and method is provided for optimizing a laser light fractionation during photodynamic therapy of a tumor. The tumor is destroyed through the production of singlet oxygen and successful photodynamic therapy treatment requires the maintenance of tu...
01/04/2000
6003321Open flow helium cryostat system and related method of using
An open flow helium cryostat system for cooling a sample crystal to be examined using X-ray diffraction, neutron diffraction, or a similar method. The cryostat system including a primary helium supply to provide a first stream of liquid helium onto the sa...
12/21/1999
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