Assignee: The University of North Carolina at Chapel Hill

Location: Chapel Hill, NC
No. of patents: 149

Number	Title	Issue Date
8173596	Prouroguanylin, and synthetic analogs or proteolytic cleavage products derived from it, as therapeutic and diagnostic agents for diseases involving salt and/or fluid homeostasis A method for treating a disorder characterized by salt retention, fluid retention, and combinations thereof. A method for determining the presence of or the progression of a disorder characterized by salt retention, fluid retention, salt loss, fluid loss, and combin...	05/08/2012
8165460	Coated filament for evaporation/condensation aerosol generation of therapeutic agents and methods for using An apparatus for generating an aerosol of a therapeutic agent and methods of using the same are disclosed. The apparatus comprises a heating element having a surface and a composition coating at least a portion of the heating element surface. The composition compris...	04/24/2012
8163151	Assays for detection of Von Willebrand factor (vWF) multimers and for degradation of vWF by agents such as Adamts13 and related methods Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers are electrophoretically separated by electrohoretic mobility in the samp...	04/24/2012
8158728	Methods and materials for fabricating microfluidic devices Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional gro...	04/17/2012
8158347	Determination of molecular age by detection of expression The presently disclosed subject matter provides methods for determining the molecular age of a tissue. Also provided are methods for employing a molecular age that has been determined for a tissue for assessing the appropriateness of various therapeutic applications...	04/17/2012
8156829	Methods of acoustic measurement and control of pharmaceutical sprays Methods of modulating a characteristic of a pharmaceutical compound spray by acoustic measurement and control of the pharmaceutical spray are disclosed. The methods include analyzing a selected characteristic of a pharmaceutical compound spray utilizing acoustic mea...	04/17/2012
8155262	Methods, systems, and computer program products for multiplexing computed tomography Methods, systems, and computer program products for multiplexing computed tomography are disclosed. According to one aspect, the subject matter described herein can include illuminating an object with a plurality of x-ray beams from a plurality of viewing angles, wh...	04/10/2012
8153589	JNK3 as a target for the treatment of angiogenesis-related diseases Provided herein are methods for treating a subject having or at risk for an angiogenesis-related disorder. The methods include administering to the subject a therapeutically effective amount of an agent that inhibits JNK3 expression, or a therapeutically effective a...	04/10/2012
8152305	Methods, systems, and computer program products for full spectrum projection A broadband electromagnetic wave beam is projected from a broadband wave source (301). The wave beam is separated by an element (306) into narrowband wavelength beams. The narrowband beams are directed across a predetermined area (312). A narrow...	04/10/2012
8150111	Methods, systems, and computer program products for processing three-dimensional image data to render an image from a viewpoint within or beyond an occluding region of the image data Methods, systems, and computer program products for processing three-dimensional image data to render an image from a viewpoint within or beyond an occluding region of the image data are disclosed. According to one method, a set of three-dimensional image data is ac...	04/03/2012
8148511	Methods and compositions for the detection and quantification of and The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in detecting the presence of these organisms in a sample, particularly using ...	04/03/2012
8101636	Linear dicationic terphenyls and their aza analogues as antiparasitic agents Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds. The presently disclosed compounds can include those of the formulas:	01/24/2012
8101191	Mycobacterial SecA2 mutants Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a m...	01/24/2012
8090164	Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning are disclosed. A method for analyzing blood vessel attributes may include developing an atlas including statistical measures for a...	01/03/2012
8013061	Polyester based degradable materials and implantable biomedical articles formed therefrom A method of making an aliphatic polyester prepolymer, comprising: reacting, alone or in combination with other reactants, a diol with at least a first diacid (or a diester of the first diacid) to produce an aliphatic polyester prepolymer. The first diacid is prefera...	09/06/2011
8008093	Inhibition of Hsp27 phosphorylation for the treatment of blistering disorders A method of treating a blistering disorder, which includes administering to a target tissue in a subject in need thereof an effective amount of a composition that inhibits activation of the HSP27 phosphorylation pathway. ...	08/30/2011
7964619	Teraryl components as antiparasitic agents Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR4. An exemplary compound of Formula (IIe)...	06/21/2011
7951827	Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that o...	05/31/2011
7939326	Methods and compositions for enhancing cell adhesion properties The present invention provides a modified cell having adhesion properties that are increased as compared to the adhesion properties of an unmodified cell, comprising a) a recombinant nucleic acid encoding an integrin β3 subunit; b) a recombinant nucleic ...	05/10/2011
7923545	Caterpiller gene family The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural motifs including a nucleotide binding domain and leucine-rich repeat dom...	04/12/2011
7923219	Ubiquitin E3 ligase The present invention provides a native or reconstituted complex comprising Bmi1 and/or Ring1 and/or Ring2, wherein the complex has ubiquitin E3 ligase activity. Optionally, the complex further comprises HPH2 and/or HPC3. Also disclosed are methods of producing the ...	04/12/2011
7906637	Compositions and methods for inducing or inhibiting activities of selected human cells Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells t...	03/15/2011
7902417	Dual catalyst system for alkane metathesis A method of converting at least one first alkane to a mixture of at least one low molecular weight alkane (optionally also including additional lower and/or higher molecular weight alkanes) and at least one high molecular weight alkane, comprising: reacting a first ...	03/08/2011
7901674	Aldehyde-fixed platelets with internalized paramagnetic or magnetic nanoparticles Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the sane. The blood cells may be red blood cells or blood platelets. ...	03/08/2011
7892809	Chimeric vectors The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as ...	02/22/2011
7887689	Method and apparatus for attaching nanostructure-containing material onto a sharp tip of an object and related articles A method for attaching nanostructure-containing material onto a sharp tip of an object includes forming a suspension of pre-formed nanostructure-containing material in a liquid medium. An electrode is immersed in the suspension. The sharp tip of the object is arrang...	02/15/2011
7846748	Methods of quantitation and identification of peptides and proteins The present invention provides methods of quantifying the amount or concentration of one or more peptides and/or proteins in one or more samples using differentially isotopically-labeled peptides and/or proteins. The invention also provides methods of identifying on...	12/07/2010
7858318	Methods and compositions for vitamin K epoxide reductase The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymor...	12/28/2010
7851144	Compositions and methods for detecting cancer The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at ris...	12/14/2010
7838531	Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis Although it can be farnesylated, the mutant lamin A protein expressed in Hutchison Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effect...	11/23/2010
7825279	Fused ring dicationic anti-protozoan agents and their prodrugs Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum. Prodrugs of these compounds can be used as an oral treatment for ma...	11/02/2010
7807400	Methods for identifying chemical modulators of Ras superfamily GTPase activity The present invention provides a method of identifying a compound having the ability to modulate the guanine nucleotide exchange cycle of a Ras superfamily GTPase, comprising: a) contacting the compound with a guanine nucleotide exchange factor and a GTPase and obta...	10/05/2010
7799526	Phosphoprotein detection reagent and methods of making and using the same A phosphoprotein detection reagent that selectively binds phosphoamino acids. Methods of generating and employing the reagent are also provided, as are methods of detecting modulation of protein phosphorylation are disclosed. Methods of detecting a change in state o...	09/21/2010
7795299	Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof. ...	09/14/2010
7780831	Assays for detection of von willebrand factor (vWF) multimers and for degradation of vWF by agents such as ADAMTS13 and related methods Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers are electrophoretically separated by electrohoretic mobility in the samp...	08/24/2010
7772458	Animal model for chronic obstructive pulmonary disease and cystic fibrosis A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subun...	08/10/2010
7745456	Synthesis and antimicrobial activity of novel dicationic “reversed amidines” The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently s...	06/29/2010
7742564	Systems and methods for detecting an image of an object by use of an X-ray beam having a polychromatic distribution Systems and methods for detecting an image of an object using an X-ray beam having a polychromatic energy distribution are disclosed. According to one aspect, a method can include detecting an image of an object. The method can include generating a first X-ray beam ...	06/22/2010
7727736	Soluble phospholipids for use in clotting factor assays The present invention provides a soluble phospholipid reagent and assays of clotting activity using the same. The methods of the invention can be used to carry out any clotting assay or other assay of clotting activity that traditionally relies on platelet membranes...	06/01/2010
7723483	Method for enhancing or inhibiting insulin-like growth factor-I The present invention provides αVβ3 integrin cysteine loop domain agonists and antagonists (including peptide agonists and antagonists and analogs thereof), along with methods of using the same. ...	05/25/2010

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Assignee: The University of North Carolina at Chapel Hill