Assignee: The University of Kentucky Research Foundation

Location: Lexington, KY
No. of patents: 77

Number	Title	Issue Date
8167955	Carbon fiber reinforced carbon foams for repair and reconstruction of bone defects The present invention relates to a tissue scaffold and a method of preparing a tissue scaffold for implantation. The tissue scaffold includes a body having a graphite foam core. At least a first portion of the external surface of that graphite foam core is covered b...	05/01/2012
7954595	Lightweight inflatable borehole receiver unit for seismic testing A borehole receiver for seismic testing has a support frame and an inflatable membrane configured to form a single, compact unit. The inflatable membrane has at least one sensor, such as an accelerometer affixed to the membrane. The at least one accelerometer may be...	06/07/2011
7932326	Chelating compounds and immobilized tethered chelators Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented. ...	04/26/2011
7867978	Methods and compositions for treating neurological disorders This disclosure relates to methods and compositions useful for the treatment of senile dementia. More particularly the disclosure relates to methods and compositions for the treatment of senile dementia related to diabetes. ...	01/11/2011
7851570	Precatalysts useful in polyolefin polymerization reactions Compounds are provided that are useful as precatlysts in the polymerization of olefins such as ethylene and propylene. Other compounds are useful as intermediates in the production of such precatalysts. ...	12/14/2010
7737327	Methods for screening for genes and small molecules that activate mammalian receptor proteins Methods for screening mutations that affect the synthesis of plant small molecules or compounds capable of activating a mammalian nuclear receptor protein and systems for rapidly assigning functionality to genes that regulate plant secondary metabolism are provided....	06/15/2010
7703479	Plasma actuator An actuator including a first and second conductor on a dielectric, wherein application of a voltage to the first conductor creates a plasma, thereby modifying a fluid flow in communication with the actuator. Related systems and methods are also provided. ...	04/27/2010
7555900	Linear actuator using shape memory wire with controller A linear actuator is provided, comprising a housing defining an interior channel, a stop extending from the housing and displaceable relative to the housing, and at least one wire formed of a shape-memory alloy, the wire being attached at a first end to the stop and...	07/07/2009
7528232	Utility of phylloplanins as antibiotics, selective fungicides and for enhancing microbial resistance in crop plants The invention is directed to methods and compositions that inhibit pathogen proliferation. More particularly, these methods and compositions involve the use of phylloplane proteins as antibiotics against human and animal pathogens. ...	05/05/2009
7442785	Sesquiterpene synthase gene and protein The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention furthe...	10/28/2008
7251032	Optical monitoring system with molecular filters An optical monitoring system for determining the constituents of a sample or specimen. An absorption spectrum is obtained from a sample and is passed through one or more filters having a specified absorption spectrum defined by a single atom or a compound. If the fi...	07/31/2007
7153525	Microemulsions as precursors to solid nanoparticles The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-...	12/26/2006
6890752	Synthases Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. ...	05/10/2005
6855270	Nanoscintillation systems for aqueous-based liquid scintillation counting The present invention relates to the use of nanoscintillation systems, or nanoparticles containing fluor molecules, that can be used to detect an electron-emitting or alpha-particle-emitting radioisotope in the absence of organic-solvents commonly used in organic-ba...	02/15/2005
6852224	Carbon fiber filters Disclosed is a filter comprised of activated carbon fibers, wherein said filter has a Virus Removal Index (hereafter “VRI”) of at least about 99%, as measured in accordance with the test method described in the specification. The filter may comprise unbound fibe...	02/08/2005
6569656	Synthases Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and...	05/27/2003
6559297	Synthases Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and...	05/06/2003
6468772	Methods of making modified polypeptides Novel polypeptides and the corresponding nucleic acids encoding such polypeptides are disclosed herein. The invention provides methods of making modified polypeptides by altering one or more amino acid residues involved in the active site of a preselected...	10/22/2002
6403602	Morphine-6-sulfate analogues and their use for the treatment of pain 3-O-Acetylmorphine-6-sulfate analogues are potent, centrally-acting morphine derivatives. The compounds are useful for the treatment of pain....	06/11/2002
6194169	Enhanced expression of human platelet-derived growth factor in Pichia pastoris Enhanced yields of the platelet-derived growth factor (PDGF) B-chain are obtained using the Pichia pastoris yeast system. Yields of both wild-type and mutant human proteins are enhanced when the yeast is transformed with a vector containing the yeast mati...	02/27/2001
6160166	Phosphonated agents and their antiangiogenic and antitumorigenic use Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is...	12/12/2000
6153621	Combined antagonist compositions Novel compositions of a combination of nicotinic, opioid, serotonergic and/or adrenergic antagonists in combination with nicotinic and opioid agonists, anti-depressants, stimulants, non-steroidal anti-inflammatory drugs, and local anesthetics, such combin...	11/28/2000
6121320	Combination anti-leukemic therapy by utilizing suramin and biologic response modifiers A method of treating leukemia which includes administering an effective amount of composition comprising suramin and a biological response modifier, wherein the suramin and the biological response modifier show synergistic or additive anti-leukemic activi...	09/19/2000
5879321	Portocaval-right atrial shunt A shunt includes a tubular body having first and second legs at a proximal end and a third leg at a distal end. A fluid distensible balloon and cooperating insufflation conduit are carried on the tubular body. The first leg of the tubular body includes a ...	03/09/1999
5879388	Implant pre-treated for reducing the generation of wear particulates A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components wherein at least one of the components is made of polymer or other material with ...	03/09/1999
5801963	Method of predicting optimum machining conditions A computer implemented method for achieving optimum selection of machining parameters and tool inserts for finish turning operations is provided. The computer implemented method allows for the simultaneous consideration of the various machining performanc...	09/01/1998
5776957	Nornicotine enantiomers for use as a treatment for dopamine related conditions and disease states Optically active nornicotine compounds as a treatment for dopamine-related conditions and disease states. Such disease states include the treatment of myasthenia gravis, Parkinson's disease, Alzheimer's disease, schizophrenia, eating disorders, ulcers, dr...	07/07/1998
5773019	Implantable controlled release device to deliver drugs directly to an internal portion of the body A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A me...	06/30/1998
5752961	Angled snare assembly A snare assembly includes an outer, flexible sheath having a distal opening and a loop received for relative sliding movement with respect to the sheath. The loop has a proximal end and a distal end. The loop is formed from a resilient wire and includes a...	05/19/1998
5702456	Implant having reduced generation of wear particulates A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components. The method includes the steps of placing the total joint orthopaedic implant in ...	12/30/1997
5693764	Nucleotide or nucleoside photoaffinity compound modified antibodies, methods for their manufacture and use thereof as diagnostics and therapeutics Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or G...	12/02/1997
5672359	Multicompartment hard capsule with control release properties The present invention relates to a hard capsule made from a material such as gelatin, starch or a hydrophilic polymer. The capsule of the present invention is formulated into a delivery system which incorporates pharmacologically active components in thre...	09/30/1997
5646009	Hybrid vector and method resulting in protein overproduction by eukaryotic cells A hybrid vector carrying a first and second DNA segments operationally linked thereto, the first DNA segment encoding a protein capable of cross-linking to the cap structure of mRNA and mediating ribosome-binding, and the second DNA segment encoding a pol...	07/08/1997
5583030	Method for obtaining antifungal and herbicidal compounds that target the first committed step in shingolipid long-chain base biosynthesis The invention provides the LCB1 and LCB2 genes of the yeast Saccharomyces cerevisiae that encode subunits of the enzyme serine palmitoyltransferase (SPT), the first enzyme leading to synthesis of the long-base component of the sphingolipids. The present s...	12/10/1996
5552440	Use of L-canavanine as a chemotherapeutic agent for the treatment of pancreatic cancer A pharmaceutical composition of canavanine, and a method treatment of cancer, particularly pancreatic cancer with L-canavanine is disclosed....	09/03/1996
5456908	Polyamine-polyamine and polyamine-protein transport inhibitor conjugates and their use as pharmaceuticals and in research relating to polyamine transport Novel classes of inhibitors which selectively inhibit the cellular transport of normally transported substances, specifically polyamines are taught which comprise (i) polymers of the transported substance or (ii) protein or polypeptide conjugates of the t...	10/10/1995
5445937	Detection of Alzheimer's disease and other diseases using an improved photoaffinity labeling method An improved method for diagnosing a disease comprising detecting a disease-specific biochemical marker macromolecule within a sample of extracted cerebral spinal fluid or serum is disclosed. In particular, a radioactively labeled photoaffinity probe is us...	08/29/1995
5434185	Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts Aurintricarboxylic acid has potent anti-angiogenic activity and may be used for new therapeutic approaches for diseases of neovascularization including the treatment of solid tumors, diabetic retinopathy and arthritis, among others....	07/18/1995
5272055	Detection of Alzheimer's disease and other diseases using a photoaffinity labeling method A method for diagnosing a neurological disease comprising detecting a neurological disease-specific biochemical marker macromolecule within a sample of extracted cerebral spinal fluid is disclosed. In particular, a radioactively labeled photoaffinity prob...	12/21/1993
5160745	Biodegradable microspheres as a carrier for macromolecules A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controll...	11/03/1992

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Assignee: The University of Kentucky Research Foundation