Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services

Location: Washington, DC
No. of patents: 174

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Number	Title	Issue Date
8175348	Segmenting colon wall via level set techniques Various level set techniques can be used to automatically segment the colon wall, including identifying the colon wall outer boundary. A speed image can be used during level set processing. For example, the speed image can be generated via inverting the gradient per...	05/08/2012
8173135	Methods for preparing complex multivalent immunogenic conjugates Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction invo...	05/08/2012
8168202	Hexavalent bovine rotavirus reassortant composition designed for use in developing countries The present invention provides vaccine compositions for protection against human rotaviral disease designed for use in particular areas of the world. Human× bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human ro...	05/01/2012
8163542	Potent combinations of mRNA transport elements This invention provides expression vectors that comprise a combination of RNA transport elements that improve expression. ...	04/24/2012
8148323	Method of treating or inhibiting inflammation by multi-domain amphipathic helical peptides Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analo...	04/03/2012
8148082	Phenylthiocarbamide (PTC) taste receptor The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, an...	04/03/2012
8143252	Tetrahalogenated compounds useful as inhibitors of angiogenesis Methods for inhibiting a neoplasm in a subject and methods of inhibiting undesired angiogenesis that include administering to a subject a therapeutically effective amount of at least one novel tetrahalogenated compound, or a pharmaceutically acceptable salt thereof....	03/27/2012
8129351	Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop...	03/06/2012
8119642	Structurally rigid dopamine D3 receptor selective ligands and process for making them A family of structurally rigid dopamine D3 receptor selective ligands is described. The family of structurally rigid dopamine D3 receptor selective ligands has the formula wherein A is cis or trans —CH═CH—, —C═C—, or cyclohexyl. B is cis or trans —CH�...	02/21/2012
8114653	Thermostable Y-family polymerases and chimeras The present disclosure is related to thermostable Y-family polymerases, in particular several novel Y-family polymerases and chimeras made therefrom, as well as methods of identifying other Y-family polymerases, methods of generating other chimeric Y-family polymera...	02/14/2012
8114406	Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins The present invention relates to a peptide comprising the sequence R1—X1—X2—X3—X4—R2, wherein X1 is selected from the group consisting of N, Q, D and S; X2 is selected ...	02/14/2012
8106026	Development of a preventive vaccine for filovirus infection in primates The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus. ...	01/31/2012
8106006	Modified defensins and their use This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods ...	01/31/2012
8105598	Human monoclonal antibodies that specifically bind IGF-II Disclosed herein are isolated monoclonal human antibodies that specifically binds insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (Kd) of 1 nM or less, wherein the antibody bind IGF-I with an equilibrium dissociation const...	01/31/2012
8092809	exotoxin A-like chimeric immunogens This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided. ...	01/10/2012
8086432	Molecular motor A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and...	12/27/2011
8084250	Defensin-antigen fusion proteins The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immuno...	12/27/2011
8080554	Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increa...	12/20/2011
8071323	Human monoclonal antibodies that bind human insulin like growth factors and their use Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided. ...	12/06/2011
8067563	Tumor suppressor gene, p471NG3 The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods ...	11/29/2011
8048630	Methods and agents for detecting The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5′NTR of parechovirus nucleic a...	11/01/2011
8048432	Polysaccharide-protein conjugate vaccines Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant....	11/01/2011
8044185	Conformationally stabilized HIV envelope immunogens and triggering HIV-I envelope to reveal cryptic V3-loop epitopes Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems includ...	10/25/2011
8044057	Methods for suppressing an immune response or treating a proliferative disorder Disclosed herein are methods for suppressing an immune response in a subject, treating a neoplasm in a subject, or treating a fibroproliferative vascular disease in a subject, that includes administering to the subject a therapeutically effective amount of a 2-(4-pi...	10/25/2011
8043622	Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for inhibiting or treating inflammatory lung disease by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. ...	10/25/2011
8038997	Anti-marinobufagenin antibodies and methods for their use Described herein are deposited hybridoma cell lines and the monoclonal antibodies produced by these hybridomas, and antigen binding fragments thereof. These monoclonal antibodies and antigen binding fragments specifically bind marinobufagenin. The disclosure also en...	10/18/2011
8034557	LMNA gene and its involvement in Hutchinson-Gilford Progeria Syndrome (HGPS) and arteriosclerosis Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter t...	10/11/2011
8030341	Dmt-derivative compounds and related compositions and methods of use The present invention relates to symmetric and asymmetric dimeric Dmt (2′,6′-ditnethyl) compounds and Dmt derivative compounds with dual δ and μ opioid receptor antagonist activity. Also, the present invention provides compositions comprising these compounds a...	10/04/2011
8029788	Variants of humanized anti-carcinoma MAb CC49 The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized monoclonal antibody (HuCC49) in which less than all six (three heavy chain a...	10/04/2011
8023710	Virtual colonoscopy via wavelets Various techniques can be used to improve classification of colon polyps candidates found via computed tomographic colonography computer aided detection (CTCCAD). A polyp candidate can be classified as a true positive or a false positive. For example, a two-dimensio...	09/20/2011
8017578	Orally active peptides that prevent cell damage and death This invention provides an ADNF polypeptide comprising an active core site, the active core site comprising at least one D-amino acid. The invention also provides a pharmaceutical composition comprising an ADNF polypeptide comprising an active core site, the active ...	09/13/2011
8012490	Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents The present invention relates to the engineering of recombinant influenza viruses that express tumor-associated antigens. Expression of tumor-associated antigens by these viruses can be achieved by engineering specific epitopes into influenza virus proteins, or by e...	09/06/2011
8008463	Compositions and methods for diagnostics and therapeutics for hydrocephalus The present disclosure relates to RFX4_v3 protein and nucleic acids encoding the RFX4_v3 protein. The present disclosure provides non-human transgenic animals with altered RFX4_v3 genes, and provides assays for the detection of RFX4_v3 and RFX4_v3 polymorphisms asso...	08/30/2011
7999077	IRTA2 antibodies and methods of use Antibodies that specifically bind the extracellular domain of IRTA2 are disclosed herein. In one embodiment, these antibodies do not specifically bind IRTA1, IRTA3, IRTA4, or IRTA5. In one example, the antibodies are humanized antibodies. The antibodies can be conju...	08/16/2011
7998682	Method for assessing atherosclerosis by measuring expression of FOS or DUSP1 in monocytes A non-invasive method for the diagnosis of atherosclerosis is provided. In one example, the method includes assaying the expression of FOS, DUSP1, or both FOS and DUSP1 in monocytes or a cell fraction thereof, or in plasma, serum or peripheral blood from the subject...	08/16/2011
7982011	Mutated anti-cd22 antibodies and immunoconjugates Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and a...	07/19/2011
7960356	Oligodeoxynucleotide and its use to induce an immune response D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′ X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6...	06/14/2011
7959929	Materials and methods for respiratory disease control in canines The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of...	06/14/2011
7954486	Aerosol delivery systems and methods Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utili...	06/07/2011
7947289	Multimeric protein toxins to target cells having multiple identifying characteristics The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating diseases. ...	05/24/2011

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Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services