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| Number | Title | Issue Date |
| 8168398 | Asbestos exposure, pleural mesothelioma, and osteopontin levels The present invention provides diagnostic methods based on levels of osteopontin. ... | 05/01/2012 |
| 8153436 | Assays for disease-associated crystals in biological samples Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging compound reactive with a plurality of crystal species under conditions tha... | 04/10/2012 |
| 8142809 | Compositions and methods to lower glycohemoglobin levels The invention provides for a diet that significantly reduces the glycohemoglobin levels in individuals with type 2 diabetes. A diet plan can be provided to an individual in the form of cards and/or pages with an appropriate meal plan, food items and/or pre-packaged ... | 03/27/2012 |
| 8124110 | Proteins with repetitive bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 02/28/2012 |
| 8101192 | Methods for producing an immune response to tuberculosis Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for preventing an infection with Mtb,... | 01/24/2012 |
| 8084023 | Maintenance and propagation of mesenchymal stem cells Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same. ... | 12/27/2011 |
| 8064994 | Cervical vagal stimulation induced weight loss Apparatus and methods for treating obesity using chronic cervical vagal nerve stimulation (cVNS) of the left vagus trunk are disclosed. Four men and ten women, average age 46 years (SD±10) were treated with output current typically 0.75 mA, pulse frequency 30 Hz an... | 11/22/2011 |
| 8053197 | Methods for detecting and treating autoimmune disorders The present disclosure relates to methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that increases FOXP3 expression, thereby inhibiting the autoimmune disease. Further disclosed herein are ... | 11/08/2011 |
| 8053181 | Methods for detecting a infection Methods for detecting an infection with Mycobacterium tuberculosis (Mtb) in a subject are disclosed. The methods include detecting the presence of CD8+T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting th... | 11/08/2011 |
| 8021673 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 09/20/2011 |
| 7972798 | Method for identifying diabetic patients at increased risk for pathological complications The present invention provides methods for detecting and measuring, in a sample from a subject, the plasma levels of endothelial cell antibodies to diagnose an increased risk of pathological complications, such as visual impairment, associated with diabetes. ... | 07/05/2011 |
| 7960606 | Mouse model of chronic heart failure and coronary atherosclerosis regression An animal model has been developed where the animals can survive myocardial infarctions caused by diet-induced coronary atherosclerosis, and live with chronic heart failure. This animal model is a result of reduced activity of scavenger receptor class BI (SR-BI) and... | 06/14/2011 |
| 7935357 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 05/03/2011 |
| 7897349 | Macrophage migration inhibitory factor (MIF) as marker for urological inflammatory disease The present invention relates to the association between detecting and quantifying the presence of macrophage migration inhibitory factor (MIF) in urine, bladder and prostate tissues for the purpose of diagnosis and prognosis of urological inflammatory. In addition,... | 03/01/2011 |
| 7892799 | Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The inte... | 02/22/2011 |
| 7888341 | Combination of glivec (STI571) with a cyclin-dependent kinase inhibitor, especially flavopiridol, in the treatment of cancer The present invention pertains to a combination for simultaneous, separate or sequential use which comprises (a) a cyclin-dependent kinase inhibitor and (b) 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide and to i... | 02/15/2011 |
| 7875710 | Nucleic acids encoding platelet derived growth factor receptor alpha (PDGFRA) activating mutations This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides metho... | 01/25/2011 |
| 7871996 | Methods of inhibiting nitric oxide synthase using corrin derivatives The present invention provides methods of inhibiting nitric oxide synthase (NOS) using corrin derivatives that bind NOS but do not bind NO. It also provides methods of inhibiting NOS in vivo by administering corrin derivatives, and methods of treating diseases and m... | 01/18/2011 |
| 7842299 | Methods for producing an immune response to tuberculosis Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for preventing an infection with Mtb,... | 11/30/2010 |
| 7816140 | Composition and methods for osteogenic gene therapy The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides... | 10/19/2010 |
| 7807374 | Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e... | 10/05/2010 |
| 7763426 | Probes and methods for detection of and antibiotic resistance Described are probes and methods for detecting pathogens and antibiotic resistance of a specimen. The method comprises contacting the specimen with a growth medium; and lysing the specimen to release nucleic acid molecules from the specimen. The lysate of the specim... | 07/27/2010 |
| 7745691 | Genetically modified mouse lacking diacylglycerol acyltransferase-1 (DGAT-1) activity Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or ... | 06/29/2010 |
| 7731973 | Method of treating immune pathologies with low dose estrogen The invention provides a method of ameliorating a Th1-mediated immune pathology in a mammal. The method is practiced by administering a low dose of estrogen to the mammal. Optionally, an immunotherapeutic agent can also be administered to the mammal. Also provided a... | 06/08/2010 |
| 7723328 | Methods of facilitating cell survival using neurotrophin mimetics Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural a... | 05/25/2010 |
| 7723037 | Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory disease The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e... | 05/25/2010 |
| 7722858 | Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of measuring the level of cLDL and/or autoantibody to cLDL in a sample obtained from this individual. The invention further discloses a m... | 05/25/2010 |
| 7690057 | Folding frame motorized prone cart A prone cart for carrying a patient has a frame, a pair of independently powered and suspended drive wheels located centrally off the frame and an articuable body support having relatively moveable tray, chest support, abdominal support and leg support sections conn... | 04/06/2010 |
| 7655472 | Treatment of disease by inducing cell apoptosis The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation o... | 02/02/2010 |
| 7635709 | Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction The present disclosure provides compositions and methods for on-going bowel care for persons with chronic intestinal pseudo-obstruction. The compositions and methods can be administered in a non-clinical setting. The compositions comprise acetylcholinesterase inhibi... | 12/22/2009 |
| 7598049 | Methods for diagnosis of Alzheimer's Disease in blood samples The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairm... | 10/06/2009 |
| 7575856 | Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant The present invention describes devices, solutions, and methods for the ex-vivo assessment, resuscitation, triage, and maintenance of human candidate cadaveric hearts. ... | 08/18/2009 |
| 7572580 | Promoter variants of the alpha-7 nicotinic acetylcholine receptor The present invention is directed to methods and compositions related to α7 acetylcholine nicotinic receptor genes, in particular, the human α7 nicotinic acetylcholine receptor gene. The human α7 nicotinic acetylcholine receptor gene is associated with the pathop... | 08/11/2009 |
| 7550299 | Method for predicting onset/risk of atrial fibrillation (AF) A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a reactive oxidative metabolite (DROM). ... | 06/23/2009 |
| 7462486 | Methods of selecting T cell receptor V peptides for therapeutic use A method is disclosed to identify a T cell receptor (TCR) variable (V) peptide of use as a therapeutic agent in a subject. A method is also disclosed for monitoring the efficacy of a T Cell Receptor (TCR) V peptide for the treatment of a subject. In another embodime... | 12/09/2008 |
| 7439024 | Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e... | 10/21/2008 |
| 7383107 | Computer-controlled power wheelchair navigation system A wheelchair navigation system for a motorized wheelchair includes dual cameras, proximity sensors, microphones, and rotation sensors for the wheels. Small markers are placed on the walls of a location or room. The navigation system uses the proximity sensors, rotat... | 06/03/2008 |
| 7354897 | Method and composition for inhibiting or slowing blood coagulation A method and composition for inhibiting or slowing blood coagulation includes lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a fragment of lactadherin. ... | 04/08/2008 |
| 7282222 | Methods and compositions for directing cells to target organs The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering stem... | 10/16/2007 |
