Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7759643 | Single electrode corona discharge electrochemical/electrospray ionization A single electrode electrochemical/electrospray ionization source using a corona discharge and a method of analyzing a sample using a corona discharge single electrode electrochemical/electrospray ionization source are provided. In the corona discharge single electr... | 07/20/2010 |
| 7657030 | Method for generating and distributing strong DES keys A method of generating a strong DES cryptographic key that doesn't require checking for parity or weak keys in the resulting key. First, all possible hexadecimal values are generated. Next, all possible two-hexadecimal value combinations are generated, where one of ... | 02/02/2010 |
| 7632508 | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an immune response to PIV or other pathogens. Also provided are isolated poly... | 12/15/2009 |
| 7358377 | Schweinfurthin analogues Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods c... | 04/15/2008 |
| 6721583 | Method for non-invasive identification of individuals at risk for diabetes The invention provides methods for the use of Raman spectroscopy to non-invasively detect molecular characteristics of the constituents of the aqueous humor, vitreous humor, lens or retina. The method can be employed for the detection of molecular changes underlying... | 04/13/2004 |
| 6692255 | Apparatus and method utilizing bi-directional relative movement for refreshable tactile display A refreshable Braille reader apparatus and method are disclosed, the apparatus preferably utilizing a rotating cylinder having endless rows of openings defined therethrough to a display surface with a pin held in each opening and freely movable therein. S... | 02/17/2004 |
| 6668207 | Method and system using power modulation and velocity modulation producing sputtered thin films with sub-angstrom thickness uniformity or custom thickness gradients A method and system for determining a source flux modulation recipe for achieving a selected thickness profile of a film to be deposited (e.g., with highly uniform or highly accurate custom graded thickness) over a flat or curved substrate (such as concav... | 12/23/2003 |
| 6268550 | Methods and a maize acetyl CoA carboxylase gene for altering the oil content of plants The present invention provides the complete cDNA sequence of maize acetyl CoA carboxylase and methods for altering the oil content of plants by introducing and expressing a plant acetyl CoA carboxylase gene in plant cells. The method of altering the oil c... | 07/31/2001 |
| 6222099 | Transgenic plants expressing maize acetyl COA carboxylase gene and method of altering oil content The present invention provides a complete cDNA sequence and partial DNA sequences encoding maize acetyl CoA carboxylase and methods for altering the oil content of plants by introducing and expressing a maize acetyl CoA carboxylase gene in plant cells.... | 04/24/2001 |
| 6194388 | Immunomodulatory oligonucleotides Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activati... | 02/27/2001 |
| 6120988 | Method of detecting hev infection Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This p... | 09/19/2000 |
| 6069298 | Methods and an acetyl CoA carboxylase gene for conferring herbicide tolerance and an alteration in oil content of plants The present invention provides the complete cDNA sequence of maize acetyl CoA carboxylase and methods for conferring herbicide tolerance and/or altering the oil content of plants by introducing and expressing a plant acetyl CoA carboxylase gene in plant c... | 05/30/2000 |
| 5849998 | Transgenic animals expressing a multidrug resistance cDNA The present invention provides for vectors carrying a cDNA containing the entire coding region of the human multidrug resistance gene (MDR1) and for a method for introducing MDR1 cDNA into cells thereby inducing a multidrug resistant phenotype.... | 12/15/1998 |
| 5792616 | Antibodies to human cripto protein A new human gene designated as "CRIPTO" gene has been identified and cloned. CRIPTO gene products and derivatives thereof have been obtained and various utilities of the same have been described. Polyclonal and monoclonal antibodies to the human CRIPTO pr... | 08/11/1998 |
| 5759782 | Cellular apoptosis susceptibility protein (CSP) and antisense CSP The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS pr... | 06/02/1998 |
| 5714329 | Methods for the diagnosis of a genetic predisposition to cancer associated with variant CDK4 allele Protein complexes consisting of a cyclin dependent kinase CDK4 and cyclin D control passage through the G1 checkpoint of the cell cycle by phosphorylating the retinoblastoma protein. The ability of these complexes to phosphorylate RB is inhibited by a fam... | 02/03/1998 |
| 5677289 | Method of cleaving specific strands of RNA and medical treatments thereby A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sen... | 10/14/1997 |
| 5587384 | Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenera... | 12/24/1996 |
| 5439824 | Increased expression of -1-antitrypsin in expression vectors through the inclusion of intron II The present invention relates to novel expression vectors and a method to increase the expression of 댑 -antitrypsin (AAT) from expression vectors encoding for the same through the inclusion of the Intron II sequence. Preferably, the Intr... | 08/08/1995 |
| 5416009 | Nucleotide molecule encoding a specific Onchocerca volvulus antigen for the immunodiagnosis of onchocerciasis The present invention relates to a DNA segment encoding an Onchocerca volvulus antigen: a specific and early marker of onchocerciasis infection. The nvention further relates to recombinant molecules containing such a segment and to methods of utilizing sa... | 05/16/1995 |
| 5040539 | Pulse oximeter for diagnosis of dental pulp pathology A non-invasive device which determines the pulp oxygenation level of a tooth and the vitality of a tooth using multiple-wavelength optical plethysmography. A sensor is shaped to be mounted on a tooth and circuitry for processing a signal from the sensor a... | 08/20/1991 |
| 5023545 | Circuit probing system A probing system for determining a voltage at a node during normal operation of a circuit. An input driver drives the circuit normally. A normal output on an output line associated with the node, is recorded. A probe is brought in contact with the node. V... | 06/11/1991 |
| 4949618 | Missile protection system A missile protection system having a meltable cover attached to a missile, the meltable cover being over the nozzle system of the missile. The missile protection system protects the nozzle system of the missile from effects of turbulent water. Such protec... | 08/21/1990 |
| 4880632 | Prevention of fescue toxicosis A method, and compositions, for use in the prevention and treatment of fescue toxicosis in animals, especially cattle, sheep and horses, comprising administering to the animals a dopamine antagonist which does not cause adverse psychological or neurologic... | 11/14/1989 |
| 4864465 | Viad chip capacitor and method for making same A two pole viad chip capacitor that is activatable from either of its sides having a plurality of ceramic layers in a stack, each and every layer having only two vias, a first via in a first region of each layer and a second via in a second region of each... | 09/05/1989 |
| 4402215 | Rheological testing method A method of testing the potential anti-misting and/or the drag reducing properties of a polymer modified fluid by testing its rheological behavior under increasing pressure. It has been found that the quantity of such fluids that can be pumped through a g... | 09/06/1983 |
| 4016303 | Method of flocking blood-contacting surfaces on artificial implant devices Blood-contacting surfaces of artificial implant devices which have been flocked with fibers of a blood-compatible polymeric material to promote formation of a stable and viable biological lining when the device has been implanted in a living body, are tre... | 04/05/1977 |
| 4015130 | Method and apparatus for monitoring optical radiation A method and apparatus for monitoring optical radiation which, in a preferred embodiment, takes the form of a biologically weighted ultraviolet radiant energy monitor which provides a direct indication of the hazards to humans from the ultraviolet radiant... | 03/29/1977 |
| 4008713 | Ultrasonic diagnostic technique utilizing switched gain signal processing An ultrasonic diagnostic technique utilized to determine the wall thickness of cardiac structures. In a preferred embodiment, the endocardial and epicardial surfaces of the left ventricular posterior wall are irradiated with an ultrasonic sound beam. The ... | 02/22/1977 |
| 4004492 | Disintegrable cartridge link An articulated belt for supporting and moving a plurality of elongate parallel objects such as gun cartridges disintegrates just as the cartridges are extracted therefrom at the gun. The belt consists of separate links, each link comprising two interlocki... | 01/25/1977 |
| 4001087 | Affinity labelling enzymes with esters of aromatic sulfonic acids Novel esters of aromatic sulfonic acids are disclosed. The specific esters are nitrophenyl p- and m-amidinophenylmethanesulfonate. Also disclosed is a method for specific inactivation of the enzyme, thrombin, employing nitrophenyl p-amidinophenylmethanesu... | 01/04/1977 |
| 3990909 | System for flushing blind cavities A blind cavity is thoroughly flushed free of foreign matter by apparatus for pumping hydraulic oil up through a tube of lesser diameter than the access opening to the cavity and returning the exit flow of the contaminated fluid to the pump through a coaxi... | 11/09/1976 |
| 3985061 | Sleeve bearing for supporting reciprocating members In bearings of sleeve configuration disposed in adjacent contact with a supply of oil for concentrically supporting a longitudinally reciprocal shaft, excessive wear of the bearings is minimized by providing an adequate oil film between the contact surfac... | 10/12/1976 |
| 3984634 | Anti-multipath digital signal detector The invention is a detector for radio signals which have been transmitted through a multipath medium. The device operates in conjunction with the radio frequency portion of a receiver to detect digital signals which have been transmitted in known modulati... | 10/05/1976 |
| 3981093 | Gas operated launcher A launching device is adapted for removable attachment to the muzzle of a rifle barrel, and has a cup holding an explosive grenade or the like in launching attitude. Upon firing a blank cartridge in the rifle, discharge gases within the barrel activate th... | 09/21/1976 |
| 3975100 | Method and apparatus for improving the accuracy of measuring the length of a gaging standard by laser interferometer means The accuracy with which the distance between the end faces of a length type of gaging standard can be measured by a laser interferometer is improved by mounting the gaging probe at one end of a slide in fixed coaxial alignment with a laser beam target sec... | 08/17/1976 |
| 3932674 | Controlled bulk vegetable fermentation Bulk fermentation of brined vegetables comprising controlled sanitizing, acidifying, buffering, and inoculating while continually purging CO2 from the fermenting vegetable/brine mass.... | 01/13/1976 |
