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| Number | Title | Issue Date |
| 8153443 | Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's D... | 04/10/2012 |
| 8147698 | Process for metabolic control and high solute clearance and solutions for use therein The present disclosure describes novel standardized citrate replacement fluid solutions and a standardized dialysate solution for use with CRRT methods. The standardized citrate replacement fluid solutions and standardized dialysate solutions do not require modifica... | 04/03/2012 |
| 8129124 | Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of sele... | 03/06/2012 |
| 8119355 | Biomarkers for cancer sensitivity and uses thereof Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity. ... | 02/21/2012 |
| 8080421 | Method for determining crystallization parameters and apparatus for use with the same The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embod... | 12/20/2011 |
| 8067001 | Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been e... | 11/29/2011 |
| 8048851 | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, t... | 11/01/2011 |
| 8039588 | Variable lymphocyte receptors Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). ... | 10/18/2011 |
| 8008074 | Compositions and methods for improving bone mass through modulation of receptors of PTH and fragments thereof The present invention relates to the discovery of novel receptors for the signaling of PTH and/or fragments of PTH, and the role of cPTH in bone development. The novel PTH receptors identified are selected from the group consisting of LRP5/6, TGFβRII, BMPRII (long ... | 08/30/2011 |
| 7994132 | Peptides for treatment of scleroderma Peptides are provided that ameliorate one or more symptoms of scleroderma. In various embodiments, the peptides range in length from about 10 to about 30 amino acids, comprise a class A amphipathic helix, and bear at least one protecting group. The peptides are high... | 08/09/2011 |
| 7986992 | Apparatus and method for treating atrial fibrillation and atrial tachycardia An apparatus for treating atrial fibrillation or atrial tachycardia comprises means for dynamically steering or selecting two or more current vector paths sequentially or simultaneously for defibrillation to change the transmembrane potential in the left and right a... | 07/26/2011 |
| 7981421 | Combinations of antibodies selective for DR5 and other therapeutic agents An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination w... | 07/19/2011 |
| 7934334 | Aiming systems Provided herein are systems for aiming devices. For example, the aiming systems can be used to aim a firearm. The aiming systems can comprise a front sight portion having a cross-section with a truncated triangle shape when viewed by an operator aiming the device. T... | 05/03/2011 |
| 7920918 | Apparatus and method for treating ventricular fibrillation and ventricular tachycardia An apparatus for treating ventricular fibrillation or ventricular tachycardia comprises means for dynamically steering or selecting two or more current vector paths sequentially or simultaneously for defibrillation so as to change the transmembrane potential in the ... | 04/05/2011 |
| 7919262 | 14-3-3 proteins for diagnosis of Parkinson's disease The present disclosure is directed to methods for treatment and prevention of disease states characterized by a decreased 14-3-3 polypeptide expression or activity. In one embodiment, the present disclosure provides methods for the treatment and/or prevention of Par... | 04/05/2011 |
| 7884132 | Process for metabolic control and high solute clearance and solutions for use therein The present disclosure describes novel standardized citrate replacement fluid solutions and a standardized dialysate solution for use with CRRT methods. The standardized citrate replacement fluid solutions and standardized dialysate solutions do not require modifica... | 02/08/2011 |
| 7850974 | Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM®-like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, and proteins and peptides obtained th... | 12/14/2010 |
| 7807640 | Orally administered peptides synergize statin activity This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are class A amphipathic helical peptides. They are highly stable and readily administered via an oral route. The peptides are effective to stimulate the form... | 10/05/2010 |
| 7798646 | Method and apparatus for the detection of impaired dark adaptation The present method describes a new method for the measurement of dark adaptation. The dark adaptation status of subjects may ten be used to identify those subjects who are at risk of developing and/or who are currently suffering from a variety of disease states havi... | 09/21/2010 |
| 7790165 | Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been e... | 09/07/2010 |
| 7776916 | Nitrated lipids and methods of making and using thereof Described herein are nitrated lipids and methods of making and using the nitrated lipids. ... | 08/17/2010 |
| 7727550 | Biologically active native biomatrix composition The present disclosure relates to a biologically active biomatrix composition. In one embodiment, the biomatrix composition is derived from human amnions. The biomatrix is termed HuBiogel™. The composition of HuBiogel™ closely mimics naturally occurring basement... | 06/01/2010 |
| 7723303 | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, t... | 05/25/2010 |
| 7713525 | Biomarkers for cancer sensitivity and uses thereof Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity. ... | 05/11/2010 |
| 7704502 | Combinations of antibodies selective for DR5 and other therapeutic agents An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination w... | 04/27/2010 |
| 7655236 | Lanthionine antibiotic compositions and methods According to the present invention, an isolated and purified DNA sequence which encodes a lantibiotic, mutacin I, is disclosed. The nucleic acid sequence is set forth in SEQ ID No: 1 and the amino acid sequence is set forth in SEQ ID No: 2. ... | 02/02/2010 |
| 7625885 | Cytotoxin compound and method of isolation A compound or groups of compounds, present in an active principle, derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds. Extracts from tunicates show selective toxicity against several ... | 12/01/2009 |
| 7615616 | Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, which can then be utilized in method... | 11/10/2009 |
| 7606274 | Mid-IR instrument for analyzing a gaseous sample and method for using the same An optical nose for detecting the presence of molecular contaminants in gaseous samples utilizes a tunable seed laser output in conjunction with a pulsed reference laser output to generate a mid-range IR laser output in the 2 to 20 micrometer range for use as a disc... | 10/20/2009 |
| 7588770 | Recombinant viruses of the paramyxoviridae family with heterologous envelope glycoproteins The invention provides recombinant viruses comprising heterologous envelope proteins capable of mediating entry of the recombinant viruses into host cells. In one embodiment, a recombinant virus of the invention is a member of the Paramyx-ovirzdae fami... | 09/15/2009 |
| 7548571 | Mid-IR microchip laser: ZnS:Cr laser with saturable absorber material A method of fabrication of laser gain material and utilization of such media includes the steps of introducing a transitional metal, preferably Cr2+ thin film of controllable thickness on the ZnS crystal facets after crystal growth by means of pulse laser... | 06/16/2009 |
| 7534603 | Fusion protein delivery system and uses thereof The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr prot... | 05/19/2009 |
| 7531514 | Orally administered peptides synergize statin activity This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. In certain embodiments, the peptides comprise an 18 amino acid class A amphipathic helix with protecting groups on the amino and the carboxyl terminus. The peptides are h... | 05/12/2009 |
| 7524510 | Alkyl-glycoside enhanced vaccination Described herein are methods for the noninvasive immunization of a subject that involve alkyl glycosides. Also described herein are compositions, kits, and devices for the noninvasive immunization of a subject. ... | 04/28/2009 |
| 7504225 | Reagents and methods for use in cancer diagnosis, classification and therapy Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subc... | 03/17/2009 |
| 7494222 | Method and apparatus for the detection of impaired dark adaptation The present method describes a new method for the measurement of dark adaptation. The dark adaptation status of subjects may then be used to identify those subjects who are at risk of developing and/or who are currently suffering from a variety of disease states hav... | 02/24/2009 |
| 7488598 | Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumor cells an... | 02/10/2009 |
| 7476383 | Antibody selective for DR4 and uses thereof An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of DR5 and DR4 a... | 01/13/2009 |
| 7473527 | Compounds promoting delivery of genes A process is provided for activating gene transfer in a cell by administering a gene transfer activating compound to the cell in conjunction with a gene transfer vector. A kit for activating gene transfer as well as process for identifying a compound that activates ... | 01/06/2009 |
| 7452420 | Apparatus and method for diamond production An apparatus for producing diamond in a deposition chamber including a heat-sinking holder for holding a diamond and for making thermal contact with a side surface of the diamond adjacent to an edge of a growth surface of the diamond, a noncontact temperature measur... | 11/18/2008 |
