Assignee: The Salk Institute for Biological Studies

Location: La Jolla, CA
No. of patents: 98

Number	Title	Issue Date
8183037	Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs This disclosure concerns compositions and methods for genetically encoding and expressing prokaryotic tRNAs in eukaryotic cells. In some embodiments, the disclosure concerns methods and compositions for expressing unnatural amino acids in eukaryotic cells using orth...	05/22/2012
8124390	Aromatic prenyltransferases, nucleic acids encoding same and uses therefor In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation...	02/28/2012
8076375	Methods of inhibiting poxvirus growth This disclosure ascribes new functions to derivatives of tetralin, anthraquinone, naphthylamine, tri-amino-pyrimidine, xanthen-3-one, and/or cinnamic acid (including, for example, NSC270718R, NSC117285R, NSC170008Y, NSC306711P, NSC119913X, NSC119915Z, NSC119911V, NS...	12/13/2011
8058502	Increasing lifespan by modulation of WWP-1 and UBC-18 Ubiquitin ligase wwp-1 and ubiquitin conjugating enzyme ubc-18 are identified in nematodes as mediators of dietary restriction induced longevity and therefore as targets for modulation of lifespan in animals. Methods of screening for compounds that modulate longevit...	11/15/2011
8013212	Site-specific recombination in eukaryotes and constructs useful therefor Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in mice. Embryonic stem cells containing recombinase nucleic acid constructs that were expressed in the male germline would simplify curren...	09/06/2011
8008542	Compositions, cells, and plants that include BKI1, a negative regulator of BRI1-mediated BR signaling This invention provides recombinant cells and transgenic plants that display selectively increased or decreased response to brassinosteroids, resulting in increased yield. Methods of modulating brassinosteroid responses, and of modulating plant phenotypes, are provi...	08/30/2011
7998487	Antitoxin and vaccine platform based on nodavirus VLPs Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs a...	08/16/2011
7972782	Steroid-activated nuclear receptors and uses therefor A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcripti...	07/05/2011
7966133	Method of identifying a potential substrates of an O-methyltransferase The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, met...	06/21/2011
7960342	Receptor(SSTR2)-selective somatostatin antagonists SRIF peptide antagonists, which are selective for SSTR2 in contrast to the other cloned SRIF receptors and which bind with high affinity to the cloned human receptor SSTR2 but do not activate the receptor, have many useful functions. Because they do not bind with si...	06/14/2011
7902422	Regulating the ethylene response of a plant by modulation of F-box proteins The invention relates to transgenic plants having reduced sensitivity to ethylene as a result of having a recombinant nucleic acid encoding an F-box protein that interacts with a EIN3 involved in an ethylene response of plants, and a method of producing a transgenic...	03/08/2011
7897637	Methods of using flavonoids to enhance memory Described herein are flavonoids (e.g., 5-desoxy flavones and/or 5-desoxy flavonols, including without limitation fisetin and its derivatives) that activate ERK and induce CREB phosphorylation in neuronal cultures, facilitate long-term potentiation in hippocampal sli...	03/01/2011
7893213	Antibodies to activin receptor In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, ...	02/22/2011
7851588	CRFR1 selective ligands CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. Some of these analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase synthesis is: (cyclo 31-34)[Ac-Pro4,D-Phe12	12/14/2010
7833727	Increasing life span by modulation of Smek The Smek (Suppressor of mek null) gene is described and characterized. Smek acts in the stress response pathway of animals by binding to and enhancing the transcription of FOXO, thereby providing the link between the stress response pathway and the insulin/IGF-1 pat...	11/16/2010
7807424	Methods of producing polyketide synthase mutants and compositions and uses thereof The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acid encoding such non-native polyketide synthases. Also disclosed are ...	10/05/2010
7792645	Three-dimensional structure of chalcone isomerase and methods of use thereof This disclosure provides crystalline flavonoid or flavanone isomerases, isolated non-native isomerase having the structural coordinates of said crystalline isomerase, and nucleic acids encoding such non-native isomerase. Also disclosed are methods of predicting the ...	09/07/2010
7785874	Compositions and methods for monosynaptic transport Disclosed herein are methods of expressing a heterologous nucleic acid sequence, such as a sequence encoding a detectable protein, in a primary neuron (or plurality of primary neurons) and other neurons that are monosynaptically connected to the primary neuron (or p...	08/31/2010
7763588	Method for increasing cognitive function and neurogenesis The invention provides a method for improving cognitive performance in a physically active subject. The invention further provides a method of enhancing neurogenesis in a physically active subject. In one embodiment, the method encompasses administering to the subje...	07/27/2010
7671085	Non-steroidal farnesoid X receptor modulators and methods for the use thereof The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accord...	03/02/2010
7647217	Structure of the farnesoid X receptor ligand binding domain and methods of use therefor The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures ...	01/12/2010
7632984	Modulation of flowering time by the pft1 locus The PFT1 (Phytochrome and Flowering Time 1) locus is described and identified. PFT1 acts in a light-quality pathway downstream of phyB that acts through modulation of FT transcription. Plants containing a truncated pft1 gene display an altered shade avoidance syndro...	12/15/2009
7612186	Compositions and methods for producing recombinant proteins A class of integral membrane proteins, referred to as Mistic polypeptides, their variants, fusion proteins including a Mistic polypeptide domain, and nucleic acid molecules encoding Mistic polypeptides and Mistic fusion proteins are disclosed herein. Also described ...	11/03/2009
7566814	Site-specific recombination in eukaryotes and constructs useful therefor The present invention relates to compositions and methods for the generation of recombinant plants by manipulation of chromosomal sequences in plant cells via recombination promoted by recombinases. Nucleic acid constructs are provided in which a germline-specific p...	07/28/2009
7544498	Aromatic prenyltransferases, nucleic acids encoding same and uses therefor In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation...	06/09/2009
7531669	Methods for treating neural disorders and conditions, and compounds useful therefor In accordance with the present invention, there are provided novel compounds that protect neurons and/or promote neuroregeneration and/or promote memory formation. Such compounds are useful for treatment of a variety of neural disorders and conditions. In another as...	05/12/2009
7501487	Retinoid receptor compositions and methods The present invention relates to novel receptor polypeptides, which, upon interaction with certain ligands, or activation by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with promoters of such genes. T...	03/10/2009
7499572	Surface segmentation from luminance and color differences A method for determining if a first pixel and a second pixel belong to a same surface includes: determining a spatial-difference value for the first pixel and the second pixel; determining one or more vision-difference values for the first pixel and the second pixel...	03/03/2009
7485434	Method for screening compounds for those that modulate transducers of regulated CREB activity In accordance with the present invention, it has been discovered that glucose and incretin hormones promote pancreatic islet cell survival via the calcium and cAMP dependent induction, respectively, of the transcription factor CREB. Specifically, a signaling module ...	02/03/2009
7439027	Method for modulating process mediated by farnesoid activated receptors Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified th...	10/21/2008
7413853	Modulation of metabolism of steroids and xenobiotics In accordance with the present invention, there are provided methods for modulating Phase II conjugating enzymes such as, for example, UGTs. Phase II conjugating enzymes such as UGTs function in concert with Phase I monooxygenase enzymes such as cytochrome P450 enzy...	08/19/2008
7384759	Methods and compositions for determinig enzymatic activity and specificity of chalcone O-methyltransferases The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyltransferases, meth...	06/10/2008
7371577	FLP-mediated gene modification in mammalian cells, and compositions and cells useful therefor A gene activation/inactivation and site-specific integration system has been developed for mammalian cells. The invention system is based on the recombination of transfected sequences by FLP, a recombinase derived from Saccharomyces. In several cell lines, FL...	05/13/2008
7361483	Aromatic prenyltransferases, nucleic acids encoding same and uses therefor In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation...	04/22/2008
7358225	Cloning and recombinant production of CRF receptor(s) In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of £ 10 nM of CRF occupy 3	04/15/2008
7314747	SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors The present invention relates to isolated polynucleotides encoding a family of silencing mediators of retinoic acid and thyroid hormone receptor (SMRT) isoforms, including vertebrate and invertebrate isoforms thereof. The invention also relates to polypeptide SMRT c...	01/01/2008
7288385	Increasing life span by modulation of Smek The Smek (Suppressor of mek null) gene is described and characterized. Smek acts in the stress response pathway of animals by binding to and enhancing the transcription of FOXO, thereby providing the link between the stress response pathway and the insulin/IGF-1 pat...	10/30/2007
7285380	Methods of producing polyketide synthase mutants and compositions and uses thereof The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are...	10/23/2007
7286712	Method and apparatus for efficiently encoding chromatic images using non-orthogonal basis functions A method and apparatus for efficiently encoding images using a set of non-orthogonal basis functions, thereby allowing reduction of file size, shorter transmission time, and improved accuracy. The non-orthogonal basis functions include homogenous color basis functio...	10/23/2007
7286973	Method of screening inhibitors of mevalonate-independent isoprenoid biosynthetic pathway The present invention provides the structure of the enzyme 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) synthase, a member of the cytidyltransferase family of enzymes from Escherichia coli. CDP-ME is a critical intermediate in the mevalonate-independent p...	10/23/2007

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Assignee: The Salk Institute for Biological Studies