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| Number | Title | Issue Date |
| 8158674 | Chalcogenoxanthylium dyes for purging blood pathogens and for photodynamic therapy Provided are chalcogenoxanthylium compounds which can effectively be used as sensitizers in photodynamic therapy, virucides in photodynamic antimicrobial chemotherapy and reversal agents of Pgp function in cancer cells. Further provided is a general method for the p... | 04/17/2012 |
| 8110218 | Compositions and methods for less immunogenic protein-lipid complexes The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comp... | 02/07/2012 |
| 8035016 | Method of using gold nanorods-siRNA complexes Provided are methods and compositions for inhibiting expression of one or more target genes. The compositions contain RNA polynucleotides that can inhibit expression of a target gene via RNA interference (RNAi) electrostatically complexed with surface functionalized... | 10/11/2011 |
| 8029698 | Production of photoluminescent silicon nanoparticles having surfaces that are essentially free of residual oxygen The present invention relates to a method for preparing photoluminescent silicon nanoparticles having uniformly hydrogen-terminated surfaces that are essentially free of residual oxygen. The present invention also relates to a method of preparing a blue-emitting pho... | 10/04/2011 |
| 8004676 | Method for detecting analytes using surface plasmon resonance A method is provided for detection of analytes using the Surface Plasmon Resonance effect. The method comprises providing a metal film on a transparent substrate. The free surface of the metal film is exposed to a test sample. An anlyte in the sample can interact di... | 08/23/2011 |
| 8003979 | High density coupling of quantum dots to carbon nanotube surface for efficient photodetection The present invention relates to a method of preparing a carbon nanotube-quantum dot conjugate having a high density of quantum dots (QDs) on its surface. This method involves providing a plurality of semiconductor quantum dots and providing a thiol-functionalized c... | 08/23/2011 |
| 7968708 | Azepans and methods for making and using same Disclosed are compounds having the formula: wherein Z1 is an alkylene moiety; Q is a carboxylic acid derivative; and R1 and R2 are the same or different and are selected from the group consi... | 06/28/2011 |
| 7920972 | G-matrix Fourier transformation (GFT) nuclear magnetic resonance (NMR) experiments for resonance assignment and structure determination of organic molecules The present invention discloses a suite of G2FT and GFT NMR experiments that can be used for complete resonance assignments of proteins and for obtaining structural (conformational and orientational) constraints for determining high resolution three-dimen... | 04/05/2011 |
| 7906500 | Chalcogenoxanthylium dyes for purging blood pathogens and for photodynamic therapy Provided are chalcogenoxanthylium compounds which can effectively be used as sensitizers in photodynamic therapy, virucides in photodynamic antimicrobial chemotherapy and reversal agents of Pgp function in cancer cells. Further provided is a general method for the p... | 03/15/2011 |
| 7901894 | Kinase inhibitors The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced using the meth... | 03/08/2011 |
| 7897108 | Sensor and method of sensing having an energy source and detector on the same side of a sensor substance A sensor has a sensor substance, an electromagnetic energy source, and a detector. The sensor substance may be able to emit electromagnetic energy different than that provided by the energy source when an analyte of interest is in contact with the sensor substance a... | 03/01/2011 |
| 7880468 | Method of using G-matrix fourier transformation nuclear magnetic resonance (GFT NMR) spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named “GFT NMR spectroscopy”, which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventio... | 02/01/2011 |
| 7875289 | Compositions of less immunogenic and long-circulating protein-lipid complexes Provided are lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In the... | 01/25/2011 |
| 7875288 | Method for treating blood coagulation disorders Provided is a method for treatment of blood coagulation disorders. The method comprises administering to an individual compositions comprising lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. One or more peptides, polypeptides ... | 01/25/2011 |
| 7869972 | Method and system for synchronous rectification The method and system of the present invention uses synchronous rectification and frequency domain analysis to remove the need for calibration of the A/D and D/A components. It is applicable to any sensor based measurement in which either the sensor can be excited w... | 01/11/2011 |
| 7851488 | Tetrahydropyridines with central nervous system activity Provided are novel tetrahydropyridine derivatives bearing substituents. These compounds can be used for alleviating the symptoms of CNS disorders. ... | 12/14/2010 |
| 7851487 | Use of tetrahydropyridines in the treatment of central nervous system disorders Disclosed are methods for alleviating symptoms of neuropsychiatric disorders using tetrahydropyridine derivatives bearing aromatic substituents. The method comprises administering to an individual a tetrahydropyridine derivative bearing aromatic substituents in an a... | 12/14/2010 |
| 7816536 | 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles and methods for making same Disclosed are 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles. Also disclosed are methods for making 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzox... | 10/19/2010 |
| 7811589 | Method for stimulating immune response against Provided is a method for stimulating in an individual an immune response against M. catarrhalis. The method is performed by administering to an individual a composition that contains at least one isolated M. catarrhalis protein in an amount effective t... | 10/12/2010 |
| 7808921 | Bridging centrality: a concept and formula to identify bridging nodes in scale-free networks A method for identifying a bridge node in a network using a processor and memory unit in a specially programmed special purpose-purpose computer including the steps of, for each node in a plurality of nodes in the network: determining a global metric proportional to... | 10/05/2010 |
| 7807422 | Production of flavonoids by recombinant microorganisms Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flav... | 10/05/2010 |
| 7794795 | Hybrid anti-fouling coating compositions and methods for preventing the fouling of surfaces subjected to a marine environment The present invention relates to a coating composition including a sol-gel matrix and a dendrimeric organochalcogeno derivative and a system including the coating composition and a substrate. The present invention also relates to a method of preventing fouling of su... | 09/14/2010 |
| 7794584 | pH-change sensor and method pH-change sensors and related methods are disclosed. One such sensor may have a first ion-sensitive transistor-operational-transconductance-amplifier (the “first IOTA”) and a second ion-sensitive transistor-operational-transconductance-amplifier (the “second I... | 09/14/2010 |
| 7776338 | Adjuvant activities of mutants of LT-IIa and LT-IIb enterotoxin lacking binding to ganglioside The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa... | 08/17/2010 |
| 7772216 | Protein kinase and phosphatase inhibitors and methods for designing them The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protei... | 08/10/2010 |
| 7767226 | Calcium sulfate based nanoparticles The present invention provides a method for facilitating repair of an area of bone by providing hemihydrate calcium sulfate particles, mixing the particles with an aqueous solution to obtain a paste, applying the paste to an area of bone in need of repair, and allow... | 08/03/2010 |
| 7750294 | Photonic sensors, xerogel-based sensors and nanosensors A photonic sensor system is provided. The system generally includes a beta emission source, optionally, a scintillation layer, and a luminophore-containing sensory layer. The system can be embodied in a particle. Also provided are photonic sensor strategies which ar... | 07/06/2010 |
| 7718094 | Preparation of metallic nanoparticles A method for the formation of metallic nanoparticles, such as gold and silver nanoparticles, which involves, combining in a single solution, solvent, metal ions and copolymers under conditions such that metal nanoparticles are formed. The copolymers have both reduci... | 05/18/2010 |
| 7700798 | Erogorgiaene congeners and methods and intermediates useful in the preparation of same Disclosed are compounds having the formula: wherein R21 is an alkyl, aryl, alkoxy, hydroxy, or amino group or a halogen atom; wherein R2 is hydrogen or an alkyl, aryl, alkoxy, or amino group; wherein R... | 04/20/2010 |
| 7684112 | Backward stimulated Rayleigh-Bragg scattering devices based on multi-photon absorbing materials and their applications The present invention relates to a method and system of generating backward stimulated Rayleigh-Bragg scattering by focusing activating radiation through a multi-photon absorbing dye solution, thereby producing coherent output radiation with no measured frequency sh... | 03/23/2010 |
| 7662928 | Anti-FcRn antibodies for treatment of auto/allo immune conditions Antibodies to heavy chain of human FcRn are provided which function as non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or antigen binding fragments thereof. These antibodies are useful for reduc... | 02/16/2010 |
| 7662750 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of... | 02/16/2010 |
| 7662405 | Compositions and methods of preparation of liposomal microparticulate IL-12 This invention provides methods and compositions for localized delivery of IL-12 to a desired site. The composition comprises liposomes carrying IL-12. The liposomes comprise phosphatidyl choline, phosphatidyl glycerol and cholesterol. The size and composition of th... | 02/16/2010 |
| 7659080 | Detecting a bacterial process in chronic rhinosinusitis The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be... | 02/09/2010 |
| 7625584 | Method of complexing a protein by the use of a dispersed system and proteins thereof The present invention relates to methods for complexing a protein in a dispersed medium. Also disclosed are associated proteins produced by the methods of complexing of the present invention. Pharmaceutically effective stabilized protein dosages are also disclosed. ... | 12/01/2009 |
| 7608237 | Synthesis of nanostructured materials using liquid crystalline templates A process for synthesizing nanostructures is disclosed. The process involves forming a liquid crystalline template by combining a block copolymer, a first reactant in a polar phase, and a nonpolar phase, then contacting the template with a gas phase composed of a se... | 10/27/2009 |
| 7598087 | Protein imprinted polymers with integrated emission sites This invention provides protein or polypeptide imprinted polymers with integrated emission sites (PIPIES) for detecting the presence of a protein or polypeptide analyte comprising templated sites which are specific for the analyte. At or near the templated sites are... | 10/06/2009 |
| 7566443 | Method for diagnosis of chronic allograft rejection The present invention provides a method for the diagnosis of chronic rejection in allografts. The method comprises identification of tertiary lymphoid organs (TLO) in the transplanted organs as a marker of chronic rejection by immunohistochemical detection for the p... | 07/28/2009 |
| 7550588 | Homotropanes with central nervous system activity Disclosed are novel homotropane compounds with CNS activity. These compounds can be used for alleviating symptoms of CNS disorders. ... | 06/23/2009 |
| 7543770 | Automated pill crusher The present invention broadly comprises an automated pill crusher comprising a container operatively arranged to hold at least one pill, means for producing a linear force in a first direction upon at least one pill in the container, and, means for producing a sprin... | 06/09/2009 |
