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Assignee: The Regents of the University of Colorado


Location: Boulder, CO
No. of patents: 118

1      
NumberTitleIssue Date
7679830Optical systems utilizing multiple phase filters to increase misfocus tolerance
An optical imaging system includes optics for imaging a wavefront of electromagnetic radiation to form an image at a detector. The system also includes a plurality of optical phase filters. Each of the phase filters alters phase of the wavefront. The phase filters c...
03/16/2010
7623685Biometric signatures and identification through the use of projective invariants
Techniques, systems and methods for obtaining biometric signatures and identification are described. Broadly stated, embodiments of the present invention utilize specified geometric principles to provide means for accurate biometric identification using projective i...
11/24/2009
7622549Human telomerase reverse transcriptase polypeptides
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu...
11/24/2009
7595686Digital controller for high-frequency switching power supplies
A voltage controller (150), the controller comprising: a voltage comparator (700) operative to provide a digital error signal (152); a compensator (300) operative to determine a digital control signal (154) based on said provided e...
09/29/2009
7585622Increasing the proliferative capacity of cells using telomerase reverse transcriptase
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu...
09/08/2009
7583167High frequency magnetic thin film filter
A layered microstrip device is described, in which at least two layers of different high internal field/high resonance frequency materials serve as the active elements of the device. The device is designed to filter ranges of high frequency electromagnetic waves, an...
09/01/2009
7560437Nucleic acid compositions for eliciting an immune response against telomerase reverse transcriptase
The present invention is directed to pharmaceutical compositions comprising a telomerase reverse transcriptase polypeptide or a polypeptide homologous to a telomerase reverse transcriptase. The present invention is also directed to pharmaceutical compositions compri...
07/14/2009
7521003Functionalized nanostructured lyotropic liquid crystal polymers
The invention provides cross-linked lyotropic liquid crystal (LLC) copolymers having ordered nanometer-sized pores lined with functional groups. The copolymers are formed by copolymerizing LLC monomers with strong LLC character and functionalized monomers with no or...
04/21/2009
7517971Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu...
04/14/2009
7498394(Meth)acrylic and (meth)acrylamide monomers, polymerizable compositions, and polymers obtained
The present invention provides novel (meth)acrylic and (meth)acrylamide monomers and polymers produced from those monomers. The monomers of the invention each include only a single vinyl functionality and at least one non-vinyl functionality that can be varied to ac...
03/03/2009
7482331Diagnosis and treatment of myocardial failure
The invention provides a method of treating myocardial failure in a human. The method comprises administering an effective amount of transgene encoding α-MHC that directly causes an increase in the quantity of α-MHC in the myocardial tissue of the heart. ...
01/27/2009
7479772Active current sharing multiphase DC-DC converter
A converter module for use as a phase in a multiphase DC-DC converter having a data bus for transferring current-sharing information is provided. The converter module includes a power stage and a controller. The power stage comprises an input for receiving an input ...
01/20/2009
7456620Determining dead times in switched-mode DC-DC converters
Systems, methods, and apparatuses are disclosed for determining dead-times in switched-mode DC-DC converters with synchronous rectifiers or other complementary switching devices. In one embodiment, for example, a controller for a DC-DC converter determines dead-time...
11/25/2008
7429387Use of botulinum toxin therapy for treatment of recalcitrant voiding dysfunction
The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin. ...
09/30/2008
7413864Treating cancer using a telomerase vaccine
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu...
08/19/2008
7388276Metal-insulator varactor devices
A varactor is configured with first and second conducting layers, spaced apart from one another such that a given voltage can be applied across the first and second conducting layers. Further, an insulator arrangement includes at least one insulator layer disposed b...
06/17/2008
7374948Methods and apparatus for detection of molecular chirality
The disclosure provides methods for the determination of the enantiomeric excess of chiral compounds. The methods involve doping a chiral analyte into an achiral liquid crystal host to form a chiral dopant/host liquid crystal mixture. An electro-optic signature of t...
05/20/2008
7340938MIS-based sensors with hydrogen selectivity
The invention provides hydrogen selective metal-insulator-semiconductor sensors which include a layer of hydrogen selective material. The hydrogen selective material can be polyimide layer having a thickness between 200 and 800 nm. Suitable polyimide materials inclu...
03/11/2008
7341836Modified cyclic nucleotide gated ion channels
The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments,...
03/11/2008
7332111Devices and methods for the production of particles
The present invention provides methods and devices for producing particles with an average diameter less than about 15 μm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-B...
02/19/2008
7316727High-selectivity supported SAPO membranes
SAPO membranes and methods for their preparation and use are described. The SAPO membranes are prepared by contacting at least one surface of a porous membrane support with an aged synthesis gel. A layer of SAPO crystals is formed on at least one surface of the supp...
01/08/2008
7297488Identifying and testing antisense oligonucleotides that inhibit telomerase reverse transcriptase
This disclosure provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cance...
11/20/2007
7291699Product and methods for diagnosis and therapy for cardiac and skeletal muscle disorders
Disclosed are products and methods to promote myoblast activation and cardiac and skeletal muscle growth or regeneration, and to treat heart and skeletal muscle diseases, based on the identification of cellular processes affected by prelamin A processing. ...
11/06/2007
7285639Antibody to telomerase reverse transcriptase
The present invention is directed to monoclonal or recombinant antibodies or fragments thereof that bind to human telomerase reverse transcriptase (hTRT) protein. The present invention is also directed to methods of identifying or detecting hTRT polypeptides in biol...
10/23/2007
7262288Nucleic acids encoding human telomerase reverse transcriptase and related homologs
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu...
08/28/2007
7242520Method for optimizing output in ultrashort-pulse multipass laser amplifiers with selective use of a spectral filter
A method for optimizing multipass laser amplifier output utilizes a spectral filter in early passes but not in later passes. The pulses shift position slightly for each pass through the amplifier, and the filter is placed such that early passes intersect the filter ...
07/10/2007
7218448Extended depth of field optical systems
A system for increasing the depth of field and decreasing the wavelength sensitivity of an incoherent optical system incorporates a special purpose optical mask into the incoherent system. The optical mask has been designed to cause the optical transfer function to ...
05/15/2007
7212723Monolithic waveguide arrays
A waveguide array is fabricated by providing a photoreactive material and generating an optical intensity pattern corresponding to a geometry of the waveguide array. A relative translation of the photoreactive material is effected through the optical intensity patte...
05/01/2007
7195911Mammalian cells that have increased proliferative capacity
The present invention is directed to cells comprising a recombinant polynucleotide sequence that encodes a telomerase reverse transcriptase protein, variant, or fragment having telomerase catalytic activity when complexed with a telomerase RNA. ...
03/27/2007
7177515Surface plasmon devices
A device including an input port configured to receive an input signal is described. The device also includes an output port and a structure, which structure includes a tunneling junction connected with the input port and the output port. The tunneling junction is c...
02/13/2007
7166463Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels
The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments,...
01/23/2007
7153514Use of botulinum toxin therapy for prostatic hyperplasia and related disorders
The present invention relates to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin. ...
12/26/2006
7113623Methods and systems for display and analysis of moving arterial tree structures
Methods and systems for reconstruction of a three-dimensional representation of a moving arterial tree structure from a pair of sequences of time varying two-dimensional images thereof and for analysis of the reconstructed representation. In one aspect of the invent...
09/26/2006
7105718Compositions and methods for regulating metabolism in plants
The invention relates to methods and products for manipulating plant metabolism and resistance to infection. ...
09/12/2006
7106510Wavefront coded imaging systems
The present invention provides improved Wavefront Coding imaging apparatus and methods composed of optics, a detector, and processing of the detected image. The optics are constructed and arranged to have the characteristic that the transverse ray intercept curves f...
09/12/2006
7083787Yeast-dendritic cell vaccines and uses thereof
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an imm...
08/01/2006
7072101Downchirped pulse amplification
An ultrashort pulse amplifier produces high-power ultrafast laser pulses. Pulses first have net negative (i.e. blue to red) chirp applied, and are then amplified in a laser amplifier. After amplification, the pulses are compressed using propagation through a block o...
07/04/2006
7066988Segmented plate for assembly within a confined area having limited access
A segmented plate adapted for assembly within a confined area or volume, and a method of assembly of the segmented plate. The plate, as assembled, has an exterior perimeter that includes exterior edge-boundaries of a plurality of generally rigid plate-sections, each...
06/27/2006
7064192High pressure refolding of protein aggregates and inclusion bodies
The present disclosure provides an effective method for the refolding of denatured proteins in solution so that properly folded, biologically active protein in solution is recovered in high yield. The refolding takes place at pressures between about 0.25 kbar to abo...
06/20/2006
7061292Adaptive voltage regulator for powered digital devices
Apparatus for efficiently supplying energy to a device in a circuit, the apparatus comprising a powered device having a critical path delay; delay line operative to model said critical path delay; control logic responsive to output from said delay line and operative...
06/13/2006
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