Assignee: The President and Fellows of Harvard College

Location: Cambridge, MA
No. of patents: 46

Number	Title	Issue Date
7799755	Immunomodulatory methods using oligosaccharides Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least one cytokin...	09/21/2010
7731946	Methods and compositions for modulating T helper (T) cell development and function Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level. ...	06/08/2010
7081238	Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient ...	07/25/2006
6989129	Automated capillary liquid chromatography small volume analysis system A system for automatically performing liquid chromatography analysis of low volume liquid chemical samples at nanosecond flow rates using an analysis column that integrates a pre-concentration trapping column and a chromatography separation column terminating at an ...	01/24/2006
6930168	Synthetic peptides for demyelinating conditions The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition. ...	08/16/2005
6660268	Proteasome regulation of NF-KB activity Disclosed herein is a method for regulating the activity of NF-.kappa.B in an animal comprising contacting cells of the animal with certain proteasome inhibitors....	12/09/2003
6358738	Polo box therapeutic compositions, methods, and uses therefor The amino acid sequence of a polo box is provided based on residue-by-residue mutation and analysis of phenotype. Additional polo boxes in the polo kinase protein located between the first polo box and the carboxy terminal are provided. Compositions and m...	03/19/2002
6333447	Transgenic model of heart failure The present invention relates to transgenic models of heart failure and, more particularly, to transgenic animals and methods for testing the usefulness of chemical compounds in treating or preventing heart failure. A transgenic mouse was developed wherei...	12/25/2001
6210667	Bacterial fibrin-dependent plasminogen activator A pharmaceutical composition in a preferred embodiment comprises an isolated bacterial protein that induces fibrin-dependent plasminogen activation, and methods for dissolving blood clots in a subject use such a composition. Embodiments also include a nuc...	04/03/2001
5972636	ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degradation which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key co...	10/26/1999
5900243	Control of insect pests Compositions are described for repelling and killing insect pests, such as fire ants and mosquitoes. Methods for controlling insect pests are found useful when applied to surfaces. A method for controlling ants, preferably fire ants, uses compositions con...	05/04/1999
5853696	Substituted 2-carboxyalkyl-3(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging agents for neurodegenerative disorders Disclosed are certain cocaine analogs useful for imaging of cocaine receptors and dopamine receptors. Also disclosed are analogs useful for imaging diagnostics for Parkinson's disease....	12/29/1998
5849548	Cell ablation using trans-splicing ribozymes The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence...	12/15/1998
5843711	Diphtheria toxin receptor-binding region The invention features a polypeptide consisting of amino acids 379-535 of diphtheria toxin, and portions thereof. This region, shown by X-ray crystallographic analysis to comprise the receptor binding domain of diphtheria toxin, is used as an immunogen an...	12/01/1998
5840832	Transcription factor regulating MHC expression, CDNA and genomic clones encoding same and retroviral expression constructs thereof The present invention relates to NF-X1, a novel DNA binding protein which regulates expression of major histocompatibility complex (MHC) class II molecules, and to DNA sequences which encode the protein as well as recombinant expression of the protein. NF...	11/24/1998
5786329	ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degradation which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key co...	07/28/1998
5780264	Iron transport protein This invention is directed to a novel protein of general significance to the cellular transport of nontransferrin bound iron. This heretofore unidentified protein, which is termed "stimulator of Fe (iron) transport" (SFT) protein, is essential to an alter...	07/14/1998
5763271	Vasodilatory and immune suppressant peptides Disclosed are proteins derived from the sand fly Lutzomyia longipalpis capable of inducing vasodilation in mammals and data characterizing the proteins and nucleic acids encoding the proteins. Also disclosed is a method for temporarily inactivating the im...	06/09/1998
5747028	Immunizing compositions comprising Vibrio cholerae expressing heterologous antigens A bacterial cell (preferably a gram-negative, enteric bacterium such as V. cholerae) the chromosome of which which contains a DNA sequence encoding a heterologous antigen, which sequence is functionally linked to an iron-regulated promoter such as the irg...	05/05/1998
5606969	Methods for measuring lung function using diffused light The method and device of the invention provides a measure of lung function at a preselected region of the lung by detecting and measuring light scattering following contact of the light onto lung tissue. Multiple parameters concerning the status of the lu...	03/04/1997
5608870	System for combining a plurality of requests referencing a common target address into a single combined request having a single reference to the target address Requests are routed between components in a parallel computing system using multiple-phase combining. In the first phase, the original requests are decomposed into groups of requests that share the same destination address. The requests in each group are ...	03/04/1997
5599672	Method of differential display of exposed mRNA by RT/PCR A method for isolating mRNAs as cDNAs employs a polymerase amplification method using at least two oligodeoxynucleotide primers. In one approach, the first primer contains sequence capable of hybridizing to a site immediately upstream of the first A ribon...	02/04/1997
5589369	Cells homozygous for disrupted target loci Homozygotic cells are obtained by employing homologous recombination with a construct comprising a marker gene. The marker gene allows for selection without amplification and by employing elevated levels of the antibiotic to which the marker gene imparts ...	12/31/1996
5589337	Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes This invention provides methods and diagnostic kits for determining the toxicity of a compound. The methods and diagnostic kits of this invention employ a plurality of bacterial hosts, each of which harbors a DNA sequence encoding a different stress promo...	12/31/1996
5565351	ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degradation which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key co...	10/15/1996
5566067	Eyelid vigilance detector system A vigilance monitoring system and method provides an alarm signal to a subject at an early stage of vigilance loss. The system includes a sensor, preferable made from a piezoelectric material, attached to the eyelid of the subject, that produces an electr...	10/15/1996
5485474	Scheme for information dispersal and reconstruction Method and apparatus applicable to a variety of data storage, data communication, and parallel computing applications, efficiently improving information availability and load balancing. Information to be transmitted in a data signal or stored is represent...	01/16/1996
5484599	Control of insect pests Compositions are described for repelling and killing insect pests, such as fire ants and mosquitoes. Methods for controlling insect pests are found useful when applied to surfaces. A method for controlling ants, preferably fire ants, uses compositions con...	01/16/1996
5397772	Vasodilatory peptides from the salivary gland of the sand fly Lutzomyia longipalpis Disclosed are proteins derived from the sand fly Lutzomyia longipalpis capable of inducing vasodilation in mammals, and data characterizing the proteins and nucleic acid encoding the proteins. Also disclosed is a method for temporarily inactivating the im...	03/14/1995
5374515	In vitro cornea equivalent model This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an i...	12/20/1994
5354670	Site-directed mutagenesis of DNA This invention pertains to a method of site-specific mutagenesis of DNA. The method can be used to mutagenize DNA, especially circular DNA (for example, virtually any plasmid), requiring only that the DNA carry a nonessential, unique recognition site for ...	10/11/1994
5308605	Diagnosis of tumors with 5-radioiodo-2'-deoxyuridine A method or the treatment and diagnosis of tumors is disclosed. This method comprises the administration of an effective amount of a radiohalogenated pyrimidine nucleoside to the tumor affected site....	05/03/1994
5288468	Parallel sequential reactor A reactor for sequentially modifying a molecule attached to a solid phase support, including: a plurality of substrate carriers, each substrate carrier capable of carrying a solid phase support to which a molecule to be modified can be attached; a plurali...	02/22/1994
5283259	Method for the prevention of ectoparasite-mediated pathogen transmission Disclosed is a method for preventing the transmission of an ectoparasite-borne pathogen to a mammal exposed to predation by the ectoparasite, wherein a time delay exists between attachment of the ectoparasite to the mammal and transmission of the pathogen...	02/01/1994
5270204	Covalent angiogenin/RNase hybrids Regional mutagenesis of a gene for angiogenin to produce DNA sequences encoding mutant proteins having increased angiogenic activity are disclosed. Expression vectors containing these sequences are introduced into host cells and direct the production of m...	12/14/1993
5266687	Inhibitors of angiogenin An inhibitor of angiogenin and method of use of the inhibitor, wherein the inhibitor inhibits the angiogenic activity of angiogenin. The inhibitor is dispensed at a suitable concentration within a physiologically compatable medium, suitable for administra...	11/30/1993
5238711	Method of coating carbon fibers with a carbide A method for rapidly providing an impervious carbon substrate such as carbon fibers with a carbide coating, in atmospheric pressure, so as to provide a carbide layer bound to the carbon substrate. A carbide layer on the impervious carbon substrate is prov...	08/24/1993
5202456	Compounds for inhibition of protein methylation The invention features a compound of the formula W-Y-Q-Z or W-Y-Z wherein W is a farnesyl group, a geranylgeranyl group, a substituted farnesyl group or a substituted geranylgeranyl group; ##STR1## wherein n=1, 2, 3, 4, 5, or 6; each of T1' . ...	04/13/1993
5196396	Method of making a superconducting fullerene composition by reacting a fullerene with an alloy containing alkali metal A method for making a superconducting fullerine composition, includes reacting a fullerine with an alloy, and particularly reacting C60 with a binary alloy including an alkali metal or a tertiary alloy including two alkali metals in the vapor p...	03/23/1993
5178911	Process for chemical vapor deposition of main group metal nitrides A process for depositing a thin film of a main group metal nitride, e.g., AlN, GaN or Sn3 N4, is provided. The vapors of a main group metal amido compound are mixed with ammonia gas and allowed to react near a substrate heated to a t...	01/12/1993

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Assignee: The President and Fellows of Harvard College