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| Number | Title | Issue Date |
| 6329757 | High frequency transistor oscillator system In a high frequency oscillator system a series oscillator circuit includes a load coil inductively coupled with a plasma generator. A capacitance is in series with the coil between the drain and source terminals of a transistor. A capacitive or inductive ... | 12/11/2001 |
| 6138082 | Standardizing between analytical instruments For conversion of spectral information of an FTIR spectrometric instrument for comparison with that of a dispersion instrument, a first standard function is selected for spectral line shape for the first instrument, and a second standard function for line... | 10/24/2000 |
| 6080985 | Ion source and accelerator for improved dynamic range and mass selection in a time of flight mass spectrometer In a mass spectrometer, an ion source in combination with an accelerator comprising an electron source, a gate electrode constructed so as to block the flow of electrons from the source when a potential is applied, a sample introduction means for transpor... | 06/27/2000 |
| 6043488 | Carrier gas separator for mass spectroscopy A system for separating certain ions from an ion beam in a mass spectrometer. A magnetic or electrostatic field is applied at an angle to the ion beam, causing the ions to disperse according to their mass to charge ratio. The ions are dispersed enough to ... | 03/28/2000 |
| 6033880 | Nucleic acid amplification reaction apparatus and method Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample th... | 03/07/2000 |
| 6015534 | PCR sample tube A one-piece sample tube for use in a PCR thermal cycler having a first substantially cylindrically shaped upper wall section having an external conically beveled shoulder moulded around the entire circumference of the section, the thickness of the wall se... | 01/18/2000 |
| 5958246 | Standardization of chromatographic systems A primary chromatographic system is operated with a standard sample at several temperatures to generate primary retention times which are fitted to a function to determine thermodynamic constants to relate the times to temperature. A target chromatographi... | 09/28/1999 |
| 5942442 | Detection of low level analytes in samples using agglutination reaction capillary slide test and apparatus therefor Apparatus and method for detection of low levels of about 1 ppb of analyte in samples using an enclosed permeable membrane enrichment device and agglutination reaction slide test apparatus.... | 08/24/1999 |
| 5933357 | Backflushing system for gas chromatography A method where the relationship between the observed retention time and the applied carrier gas pressure can be fitted to an expected theoretical relationship and thus enable the retention time on just the precolumn to be precisely derived. This method, u... | 08/03/1999 |
| 5925266 | Mounting apparatus for induction coupled plasma torch In a mounting apparatus for an induction coupled plasma generator, a housing assembly has a receptacle with a central opening aligned over a housing wall opening, electrical contact rings in the receptacle, and a gas block with a central aperture aligned ... | 07/20/1999 |
| 5915269 | Method and apparatus to compensate for gas chromatograph column permeability In a gas chromatograph system having a column with a stationary phase and a carrier gas moving through the column to contact the stationary phase, the system being useful for detecting analytes in a sample, a method and apparatus for predicting the retent... | 06/22/1999 |
| 5902722 | Method of detecting organisms in a sample The presence or absence of an organism in a sample is detected by isolating the organism from the sample by a suitable affinity matrix, releasing the organism from the affinity matrix, rupturing the cells of the organism to release total nucleic acid and ... | 05/11/1999 |
| 5891740 | Detection of low level hydrophobic analytes in environmental samples using agglutination reaction capillary slide test and apparatus therefor Apparatus and method for detection of low levels of about 1 ppb of hydrophobic analyte in environmental samples using an enclosed permeable membrane enrichment device and agglutination reaction slide test apparatus.... | 04/06/1999 |
| 5876118 | Calorimeter having rapid cooling of a heating vessel therein A calorimeter apparatus includes a facility for rapid cooling of a heating vessel therein. A jacket surrounds the vessel wall. A partition member between the jacket and the vessel wall defines an inlet plenum adjacent the jacket and a spatial gap adjacent... | 03/02/1999 |
| 5827480 | Nucleic acid amplification reaction apparatus Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample th... | 10/27/1998 |
| 5779977 | Nucleic acid amplification reaction apparatus and method Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample th... | 07/14/1998 |
| 5766889 | Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample Apparatus and method for determining an unknown starting molar concentration of target nucleic acid molecules at the beginning of a polymerase chain reaction in a sample reaction mixture containing suitable buffers, two complementary kinds of oligonucleot... | 06/16/1998 |
| 5762381 | Connecting apparatus for conveyance of cryogenic fluid A connecting apparatus for conveyance of cryogenic fluid has a pair of connecting members formed of thermal insulating material. Each has a flange with an axial tubular protrusion and a rim extending over the protrusion so as to form an annular cavity the... | 06/09/1998 |
| 5720923 | Nucleic acid amplification reaction apparatus Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample th... | 02/24/1998 |
| 5716082 | Fluid conveying device with removable connection A cryogenic fluid conveying device has removable connection of a metal tube and a receptor for the tube. The receptor is formed of a housing member with an aperture therein for conveying the fluid. A tubular member of resilient PTFE has a bore size so as ... | 02/10/1998 |
| 5716784 | Fluorescence detection assay for homogeneous PCR hybridization systems An improved assay system for homogeneous assay detection and/or measuring target nucleic acid sequence replicated in a PCR amplification procedure is provided by employing a nucleic acid polymerase having 5' to 3' exonuclease activity and devoid of 3' to ... | 02/10/1998 |
| 5711786 | Gas chromatographic system with controlled sample transfer In a gas chromatographic system that includes a column and an injector with a chamber, a carrier gas normally flows into the chamber at a constant rate, and a constant primary pressure is maintained at the column inlet. A sampling receptacle selectively c... | 01/27/1998 |
| 5710381 | Two piece holder for PCR sample tubes A two-piece plastic holder for loosely holding microliter sample tubes of a preselected design, each tube having a cylindrically shaped upper section open at its top end, a closed, tapered lower section extending downwardly therefrom, and a circumferentia... | 01/20/1998 |
| 5681741 | In situ PCR amplification system A complete in situ PCR system for amplification of nucleic acids contained in a prepared cell or tissue sample. The containment system for the PCR sample comprises a glass microscope slide, a specimen sample containing the target nucleic acid sequence mou... | 10/28/1997 |
| 5675700 | Assembly system for in situ per amplification A complete in situ PCR system for amplification of nucleic acids contained in a prepared cell or tissue sample. The containment system for the PCR sample comprises a glass microscope slide, a specimen sample containing the target nucleic acid sequence mou... | 10/07/1997 |
| 5672289 | Heater control circuit A Control circuit for a differential scanning calorimeter which includes a sample heater, a reference heater, a system for generating a sample heater DC voltage and a system for generating a reference heater DC voltage. A balanced operational amplifier ar... | 09/30/1997 |
| 5671603 | Apparatus for controlling level of cryogenic liquid An apparatus for controlling level of cryogenic liquid in a vessel includes a transfer duct to a pressure supply tank. Pressure pulses are applied to the tank at one rate when the level is below a primary sensor in the vessel, and at a lower rate when the... | 09/30/1997 |
| 5656493 | System for automated performance of the polymerase chain reaction There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to... | 08/12/1997 |
| 5655681 | Thermal insulating container for liquified gas A thermally insulated calorimeter includes a vessel with a chamber containing liquid nitrogen. The vessel is formed of four walls arranged proximately in parallel, each pair of adjacent walls delimiting a space. An inner wall forms the chamber, two partit... | 08/12/1997 |
| 5602756 | Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled ... | 02/11/1997 |
| 5590537 | Dry gas curtain for cryogenic surface An apparatus to provide a laminar curtain of dry gas over a cryogenic working surface includes a housing duct extending longitudinally from the working surface. A honeycomb member fills a section of the duct adjacent to the working surface, each honeycomb... | 01/07/1997 |
| 5580732 | Method of DNA sequencing employing a mixed DNA-polymer chain probe Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized... | 12/03/1996 |
| 5565983 | Optical spectrometer for detecting spectra in separate ranges A spectrometer includes a pair of crossed reflective gratings to effect a spectrally dispersed beam that is focussed to an array detector. The second grating is a plural grating with a surface formed of a first portion and a second portion. The first port... | 10/15/1996 |
| 5549387 | Apparatus and method for differential analysis using real and imaginary signal components The invention is directed to a differential analysis method and apparatus wherein a sample and reference are subjected to an externally applied disturbance, such as temperature change, in accord with a prescribed function comprising the sum of a linearly ... | 08/27/1996 |
| 5545252 | Flow regulation in gas chromatograph A gas chromatographic system includes a column and an injector for delivering into the column a test portion of flow. The injector has an exit passage for discharging a split portion of carrier flow. A flow controller for regulating the inlet flow rate in... | 08/13/1996 |
| 5528370 | Apparatus and method for measuring variations in thickness of an optical interference element In a system for measuring variations in thickness of an optical etalon, a light source and a diffraction grating are mounted on a base structure with an axle. A lever arm is affixed to the axle, and a micrometer is held in contact with the lever arm. The ... | 06/18/1996 |
| 5527510 | In situ PCR amplification system A complete in situ PCR system for amplification of nucleic acids contained in a prepared cell or tissue sample. The containment system for the PCR sample comprises a glass microscope slide, a specimen sample containing the target nucleic acid sequence mou... | 06/18/1996 |
| 5526451 | Photometric instrument with optical fibers for analyzing remote samples In a spectrophotometer, each of a plurality of source optical fibers is selectively receptive of source radiation and carries the radiation to a corresponding selected liquid sample cell. A corresponding return optical fiber returns transmitted radiation ... | 06/11/1996 |
| 5480783 | Method for reducing background signals in DNA replication/detection assays A kit and method for reduction of primer-independent background signals in a DNA replication/detection assay, particularly in a direct in situ PCR amplification/detection assay, for a target DNA sequence in DNA sample, comprising pretreating the DNA sampl... | 01/02/1996 |
| 5481631 | Optical switching apparatus with retroreflector An optical switch includes a primary optical fiber terminating in a primary window, and a plurality of secondary optical fibers each terminating in a secondary window facing in the same direction as and spaced laterally from the primary window. A primary ... | 01/02/1996 |
