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| Number | Title | Issue Date |
| 8183745 | High frequency ultrasound transducers An example ultrasound device, such as a transducer array, includes a plurality of ultrasound transducers, each ultrasound transducer having a first electrode, a second electrode, a thin piezoelectric film located between the electrodes, and a substrate supporting th... | 05/22/2012 |
| 8175712 | Homotopic conditioning of the brain stem baroreflex of a subject Disclosed are methods for regulating blood pressure in a subject which include administering a first induction stimulus effective to sensitize brainstem baroreflex neurons of a subject for a period of time in the range of about 10-15 hours thereby producing an enhan... | 05/08/2012 |
| 8173825 | Method of making fatty acid ester derivatives Fatty acid ester derivatives and a process for their production from unsaturated fatty acids are disclosed. The process comprises: a) reacting an unsaturated fatty acid or an ester thereof having one or more sites of unsaturation, with an epoxidation re... | 05/08/2012 |
| 8163976 | Compositions and methods relating to transgenic plants and cellulosic ethanol production Transgenic lignocellulosic plants are provided according to embodiments of the present invention, the transgenic plants transformed with an expression cassette encoding a protein operably linked to a signal peptide which targets the protein to a cell wall of the tra... | 04/24/2012 |
| 8163505 | Methods using PBK1 for identifying agents that treat metabolic disorders The invention relates to compositions comprising, and methods utilizing PBK1 protein and DNA, including a method of detecting type 1 diabetes; a mammalian pancreas-derived cell comprising a recombinant nucleic acid encoding a PBK1 protein; a method of identifying a ... | 04/24/2012 |
| 8163347 | High energy density nanocomposites and related methods of preparation Disclosed are metal oxide-polymer composites having a substrate comprising a metal oxide component, an aluminum oxide component, and a metallocene olefin polymerization catalyst component coupled to the substrate. The compositions can be used as thin films in an ins... | 04/24/2012 |
| 8161973 | Reversible vasectomy device and method A reversible vasectomy device includes a first and a second connector piece for attachment to the severed ends of the vas deferens. Each connector piece has an outer vas deferens attaching end, an opposite inner end, and a passage from the outer to the inner end. A ... | 04/24/2012 |
| 8158843 | Deep desulfurization of hydrocarbon fuels The invention relates to processes for reducing the sulfur content in hydrocarbon fuels such as gasoline, diesel fuel and jet fuel. The invention provides a method and materials for producing ultra low sulfur content transportation fuels for motor vehicles as well a... | 04/17/2012 |
| 8137913 | Methods for nucleic acid manipulation A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The... | 03/20/2012 |
| 8129116 | Methods for nucleic acid manipulation A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The... | 03/06/2012 |
| 8120770 | Three-dimensional (3D) hydrodynamic focusing using a microfluidic device A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-o... | 02/21/2012 |
| 8113069 | Aerodynamic sampler for chemical/biological trace detection An aerodynamic sampler for sampling particles from a surface or a flowing gas stream is provided. The sampler can include an arcuate-shaped shroud having a first opening and a second opening, the first opening being directed in a first direction and the second openi... | 02/14/2012 |
| 8108152 | Method for redesign of microbial production systems A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least... | 01/31/2012 |
| 8093487 | Removable protective nose cover A removable protective nose cover for a submersible structure having a nose section is disclosed. The removable protective nose cover can include a plurality of shell members, each of the shell members having a forward end and an aft end. Each shell member can also ... | 01/10/2012 |
| 8093212 | Methods of treating nerve-related vision disorders by an insulinomimetic agent This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes for treatment of nerve-related vision disorders such as diabetic reti... | 01/10/2012 |
| 8086414 | Method and system for modeling cellular metabolism This invention relates to methods and systems for in silico or bioinformatic modeling of cellular metabolism. The invention includes methods and systems for modeling cellular metabolism of an organism, comprising constructing a flux balance analysis model, and apply... | 12/27/2011 |
| 8080240 | Parvovirus methods and compositions for killing neoplastic cells According to the invention, parvoviruses such as the adeno-associated virus Type 2 (AAV2) are found to be oncolytic, selectively mediating apoptosis in cancer cells and their precursers, while leaving healthy cells intact. The invention thus comprises a method of ki... | 12/20/2011 |
| 8071132 | Unagglomerated core/shell nanocomposite particles The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a s... | 12/06/2011 |
| 8064669 | Fast 3D-2D image registration system with application to continuously guided endoscopy A novel framework for fast and continuous registration between two imaging modalities is disclosed. The approach makes it possible to completely determine the rigid transformation between multiple sources at real-time or near real-time frame-rates in order to locali... | 11/22/2011 |
| 8052960 | Netrin-1 as a biomarker of injury and disease Detection and diagnosis of injury and/or disease in a subject can be key to preventing irreversible damage and death. Methods of aiding detection and assessment of a disease or condition in a subject are which include assaying netrin-1 protein and/or nucleic acid in... | 11/08/2011 |
| 8052848 | Ultrasonic and microwave methods for enhancing the rate of a chemical reaction and apparatus for such methods The invention relates generally to chemical reactions and processes, and in particular to a method for enhancing the rate of a chemical reaction and to apparatus for carrying out the method. The invention more particularly relates to methods and apparatus which util... | 11/08/2011 |
| 8048629 | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection tumor-associated DNA, and to ... | 11/01/2011 |
| 8027821 | Method for determining gene knockouts A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioenginee... | 09/27/2011 |
| 8025297 | Bellows with alternating layers of high and low compliance material for dynamic applications A bellows has a generally tubular elongated bellows body. The bellows body is defined by a wall generally enclosing a volume. The wall has a generally cylindrical inner surface and a generally cylindrical outer surface. The bellows body is formed by alternating laye... | 09/27/2011 |
| 8021501 | Single point incremental forming of metallic materials using applied direct current A method for forming a sheet metal component using an electric current passing through the component is provided. The method can include providing a single point incremental forming, the machine operable to perform a plurality of single point incremental deformation... | 09/20/2011 |
| 8003633 | Anti-cancer compositions and methods Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: where R is phenyl, where R1 is (CH2)n—Se—C(═NH)—NH2, where R2 is (CH2)n—Se—C(═NH)... | 08/23/2011 |
| 8003630 | Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor The present invention relates to pharmaceutical compositions for treating neoplasias in an animal or human comprised of a carrier and therapeutically effective amounts of at least one chemotherapeutic agent along with the biotherapeutic endogenous pentapeptide Met-e... | 08/23/2011 |
| 7992674 | Dipole flow driven resonators for fan noise mitigation A fan system includes a rotor supported for rotation about a fan axis. The rotor has a central hub and a plurality of blades each extending outwardly from the hub to a tip. The rotor blades define a rotor plane perpendicular to the fan axis. A first acoustic resonat... | 08/09/2011 |
| 7989615 | Separation of different isoforms of plasmid DNA using ultrafiltration The invention is a method for isolating a desired plasmid DNA isoform, typically a supercoiled isoform, which includes the steps of obtaining a quantity of bioreactor produced plasmid DNA in liquid form for purification, and passing the plasmid DNA through an ultraf... | 08/02/2011 |
| 7960361 | Nucleic acid cancer immunotherapy A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to t... | 06/14/2011 |
| 7959806 | Mine influenced water remediation using bioremediation substrate A new and improved method for treating mine influenced water (MIW) or other environmental contamination is disclosed. A number of electron donors are disclosed, including chitin complex-containing materials. The chitin complex-containing materials may modify the pH ... | 06/14/2011 |
| 7956029 | Synthetic mimics of mammalian cell surface receptors: method and compositions The present invention relates to new synthetic receptors. More particularly, the present invention relates to the use of the synthetic receptors for delivering a protein, peptide, drug, prodrug, lipid, nucleic acid, carbohydrate or small molecule into a target cell ... | 06/07/2011 |
| 7947647 | Synthetic mimics of mammalian cell surface receptors: method and compositions The present invention relates to new synthetic receptors. More particularly, the present invention relates to the use of the synthetic receptors for delivering a protein, peptide, drug, prodrug, lipid, nucleic acid, carbohydrate or small molecule into a target cell ... | 05/24/2011 |
| 7941009 | Real-time computerized annotation of pictures A computerized annotation method achieves real-time operation and better optimization properties while preserving the architectural advantages of the generative modeling approach. A novel clustering algorithm for objects is represented by discrete distributions, or ... | 05/10/2011 |
| 7935487 | Method of detecting tumor-associated DNA in plasma or serum from humans without cancer This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant... | 05/03/2011 |
| 7935484 | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assay This invention relates to detection of specific extracellular nucleic acid in human or animal blood plasma or serum associated with disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA ... | 05/03/2011 |
| RE42313 | Chemically modified vegetable oil-based industrial fluid Triglyceride oils having unsaturated fatty acid substituents are modified to convert sites of unsaturation to C-2 to C-10 diesters. The resulting derivatives are characterized by thermal and oxidative stability, have low temperature performance properties and are en... | 04/26/2011 |
| 7929805 | Image-based CAPTCHA generation system In a system and method for the generation of attack-resistant, user-friendly, image-based CAPTCHAs (Completely Automated Public test to Tell Computers and Humans Apart), controlled distortions are applied to randomly chosen images and presented to a user for annotat... | 04/19/2011 |
| 7927760 | Methods to control water flow and distribution in direct methanol fuel cells A direct methanol fuel cell unit is provided with a fuel cell including an anode, a cathode with a hydrophobic microporous layer, an electrolyte membrane put in-between, and a fuel supply path supplying fuel to the anode. The fuel supply path is provided with an upw... | 04/19/2011 |
| 7927068 | Expandable impeller pump An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one... | 04/19/2011 |
